Fmoc-L-亮氨酸, 过氧化物酶体增殖激活受体-γ 的激动剂

增加细胞内钙离子水平

3篇引用文献

COA

级别和纯度:

Moligand™

≥98%

CAS编号: 35661-60-0
分子式: C₂₁H₂₃NO₄
分子量: 353.41
Beilstein号: 2178254
EC号: 252-662-7
MDL号: MFCD00037133
PubChem编号: 1549133
PubChem SID: 504760586

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货号 (SKU)	包装规格	是否现货
F100808-5g	5g	现货
F100808-25g	25g	现货
F100808-100g	100g	现货
F100808-500g	500g	期货

查看相关系列

Cell Cycle (7376) Cell Cycle/DNA Damage (2603) Peroxisome proliferator-activated receptor-γ Agonist (52) PPAR (154) Vitamin D Related/Nuclear Receptor (908) 脂质代谢 (4331)

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基本描述

别名	N-芴甲氧羰基-L-亮氨酸 \| N-[(9H-芴-9-基甲氧基)羰基]-L-亮氨酸 \| N-Fmoc-L-亮氨酸
英文别名	Maybridge1_005562 \| MFCD00037133 \| HMS557E18 \| N-(Fluoren-9-ylmethoxycarbonyl)-L-leucine \| NSC-334290 \| AC-24092 \| AKOS010398974 \| Fmoc-Leu-OH \| Z1123720065 \| KF18F70UF3 \| N-((9H-FLUOREN-9-YLMETHOXY)CARBONYL)-L-LEUCINE, (-)- \| NCGC00255677-01 \| BDBM115093
规格或纯度	Moligand™, ≥98%
英文名称	Fmoc-Leu-OH
生化机理	抗炎药；增加细胞内Ca2 +水平。
储存温度	2-8°C储存
运输条件	冰袋运输
作用类型	激动剂
作用机制	过氧化物酶体增殖激活受体-γ 的激动剂
产品介绍	PPARγ的配体，诱导胰岛素的敏感性，而不是脂肪细胞分化应用 Fmoc-Leu-OH可用作合成反应剂：通过与功能化α-氨基酸盐酸盐反应合成寡肽。环酯Sansalvamide A，这是在海洋真菌中发现的一种天然产物。 Streptocidin A−D，放线菌Tü 6071中天然存在的十肽抗生素。酰基二肽酰胺，可用于化妆品应用。
纯度	≥98%

关联靶点（人）

NTSR1 Tchem 神经降压素受体 1 型(Neurotensin receptor type 1) (0 活性数据)

点击查看靶蛋白信息： NTSR1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

PPARG Tclin 过氧化物酶体增殖激活受体γ(Peroxisome proliferator-activated receptor gamma) (1 活性数据)

点击查看靶蛋白信息： PPARG

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)

点击查看靶蛋白信息： NR3C1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 活性数据)

点击查看靶蛋白信息： PPARG

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 活性数据)

点击查看靶蛋白信息： RXRA

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

AHR Tclin Aryl hydrocarbon receptor (1071 活性数据)

点击查看靶蛋白信息： AHR

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 活性数据)

点击查看靶蛋白信息： GLP1R

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

NR1H2 Tchem LXR-beta (3841 活性数据)

点击查看靶蛋白信息： NR1H2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

BRCA1 Tchem Breast cancer type 1 susceptibility protein (15908 活性数据)

点击查看靶蛋白信息： BRCA1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SNCA Tchem Alpha-synuclein (10960 活性数据)

点击查看靶蛋白信息： SNCA

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 活性数据)

点击查看靶蛋白信息： SLC36A1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CTNS Tbio Cystinosin (2 活性数据)

点击查看靶蛋白信息： CTNS

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Ppard Peroxisome proliferator-activated receptor delta (358 活性数据)

点击查看靶蛋白信息： Ppard

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 活性数据)

点击查看靶蛋白信息： Hdac6

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)

点击查看靶蛋白信息： Nfe2l2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 活性数据)

点击查看靶蛋白信息： Nr1i2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504760586
EC号	252-662-7
分子类型	小分子
IIUPAC Name	(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentanoic acid
INCHI	1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m0/s1
InChi Key	CBPJQFCAFFNICX-IBGZPJMESA-N
Smiles	CC(C)CC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Isomeric SMILES	CC(C)C[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
分子量	353.41
Beilstein号	2178254
Reaxy-Rn	2307798
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2307798&ln=

化学和物理性质

溶解性	溶于DMSO, 最高浓度 (mg/mL): 35.34, 最高浓度(mM): 100 温和加热
密度	1.207
比旋光度	-25 ° (C=1, DMF)
熔点	153-157°C
分子量	353.400 g/mol
XLogP3	4.400
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	7
精确质量Exact Mass	353.163 Da
单同位素质量Monoisotopic Mass	353.163 Da
拓扑极表面积Topological Polar Surface Area	75.600 Å²
重原子数Heavy Atom Count	26
形式电荷Formal Charge	0
复杂度Complexity	484.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	1
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

信号词	Warning
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
WGK Germany	3
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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批号(Lot Number)	证书类型	货号
H2512589	分析证书	F100808
H2512597	分析证书	F100808
J2514796	分析证书	F100808
H2504270	分析证书	F100808
H2504273	分析证书	F100808
H2124220	分析证书	F100808
H2124221	分析证书	F100808
H2124226	分析证书	F100808
H2124387	分析证书	F100808
E2515324	分析证书	F100808
E2515305	分析证书	F100808
E2515323	分析证书	F100808
C1912133	分析证书	F100808
I2215178	分析证书	F100808
I2215179	分析证书	F100808
I2215193	分析证书	F100808
I2215194	分析证书	F100808
H2401033	分析证书	F100808
I2423655	分析证书	F100808

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11. Fan Gao,Chi Zhang,Wen-Xiu Qiu,Xue Dong,Di-Wei Zheng,Wei Wu,Xian-Zheng Zhang. (2018-08-22) PD-1 Blockade for Improving the Antitumor Efficiency of Polymer-Doxorubicin Nanoprodrug.. Small (Weinheim an der Bergstrasse, Germany), 14 ((37)): (e1802403-e1802403). [PMID:30129176]
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