EWP 815

COA

级别和纯度:

≥98%

CAS编号: 20231-01-0
分子式: C₁₂H₂₂N₄S₄
分子量: 350.59
PubChem编号: 30054

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货号 (SKU)	包装规格	是否现货
E648767-5mg	5mg	期货
E648767-10mg	10mg	期货
E648767-25mg	25mg	期货
E648767-50mg	50mg	期货
E648767-100mg	100mg	期货

查看相关系列

Amino Acid/Protein Metabolism (4559) Dopamine β-hydroxylase (11) Glucose Metabolism (3713) Metabolic Enzyme/Protease (4889) Phosphatase (222)

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基本描述

规格或纯度	≥98%
英文名称	EWP 815
生化机理	EWP 815 是一种双硫仑类似物，是 Ins(1,4) P 2 磷酸酶和 Ins(1,4,5) P 3 5-磷酸酶的强效抑制剂。EWP 815 还能抑制多巴胺 β- 羟化酶的活性。
储存温度	2-8°C储存,避光
运输条件	冰袋运输
作用类型	抑制剂
产品介绍	EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4) P 2 phosphatase and Ins(1,4,5) P 3 5-phosphatase . EWP 815 also inhibits enzyme dopamine β-hydroxylase activity In Vitro EWP 815 inhibits thyrotropin-releasing hormone (TRH; 0.03 mM)-stimulated inositol phospholipid breakdown without affecting basal breakdown rates in prelabelled GH 3 cells with IC 50 s of 83 mM (soluble enzymes) and 71 mM (particulate enzymes), respectively. EWP 815 (30 μM; 1 h) exerts higher inhibition on Ins(1,4) P 2 phosphatase rather than Ins(1,4,5) P 3 5-phosphatase with the mean [ 3 H]Ins(1,4) P 2 /mean [ 3 H]Ins P recovery ratio of 2.6. EWP 815 (6, 8 μM; 10 min) inhibits dephosphorylation of [ 3 H]Ins(1,4,5) P 3 5-phosphatase in particulate and soluble fractions with IC 50 s of 6 μM and 8 μM, respectively. EWP 815 (3-300 μM; 30 min) suppresses thyrotropin-releasing hormone (TRH)-stimulated (100 nM) inositol phospholipid production by 30% (100 μM) and 1.8% (300 μM), respectively, without affecting Ins(1,4,5) P 3 binding. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo EWP 815 (50 mg/kg; i.p.; 30 min before killed) inhibits the enzyme dopamine β-hydroxylase activity in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female mice (20 g)Dosage: 50 mg/kg Administration: Intraperitoneal injection; 30 min before killed Result: Intraperitoneal injection; 30 min before killedInhibited β-hydroxylase of 3 H-α-methyldopamine. Reduced the amount of 3 H-α-Me-NA by 12%. Form:Solid IC50& Target:Ins(1,4)P2 phosphatase,Ins(1,4,5)P3 5-phosphatase, ,dopamine β-hydroxylase
纯度	≥98%

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点击查看靶蛋白信息： MGLL

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关联靶点（其它种属）

Faah Anandamide amidohydrolase (3907 活性数据)

点击查看靶蛋白信息： Faah

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
Isomeric SMILES	CN1CCN(CC1)C(=S)SSC(=S)N2CCN(CC2)C
PubChem CID	30054
分子量	350.59

化学和物理性质

溶解性	DMSO : 50 mg/mL (142.62 mM; Need ultrasonic)
分子量	350.600 g/mol
XLogP3	1.300
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	6
可旋转键计数Rotatable Bond Count	3
精确质量Exact Mass	350.073 Da
单同位素质量Monoisotopic Mass	350.073 Da
拓扑极表面积Topological Polar Surface Area	128.000 Å²
重原子数Heavy Atom Count	20
形式电荷Formal Charge	0
复杂度Complexity	315.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

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