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鞣花酸

选择性酪蛋白激酶2（CK2）抑制剂
50篇引用文献 COA COA
    级别和纯度:
  • ≥96%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
E102710-1g
 1g 现货 Stock Image
E102710-5g
 5g 现货 Stock Image
E102710-25g
 25g 现货 Stock Image
E102710-100g
 100g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Casein Kinase (72) Cell Cycle (7376) Cell Cycle/DNA Damage (2603) Endogenous Metabolite (978) Glucose Metabolism (3713) Immunology/Inflammation (1938) Metabolic Enzyme/Protease (4889) NF-κB (756) Non-receptor Tyrosine Kinase (1390) Reactive Oxygen Species (316) Stem Cell/Wnt (1018) 代谢物 (8911) 苯丙素类 (153) 香豆素类 (73)
main product photo

基本描述

别名 棓原 | 逆没食子酸 | 2,3,7,8-四羟基-[1]-苯并吡喃并[5,4,3-cde][1]苯并吡喃-5,10-二酮 | 4,4′,5,5′,6,6′-六氢二苯二甲酸2,6,2′,6′-二内酯
英文别名 BBL009292 | NSC 656272 | TNP00132 | Acidum ellagicum [INN-Latin] | BRN 0047549 | Ellagicacid | ellagic-acid | Oprea1_032884 | 2,3,7,8-tetrahydroxychromeno(5,4,3-cde)chromene-5,10-dione | Benzoarate | Benzoaric acid | Ellagsaeure | Llagate | SCHEMBL20429 |
规格或纯度 ≥96%
英文名称 Ellagic acid
生化机理 常见的植物多酚，谷胱甘肽 S 转移酶的抑制剂。 用于检测血浆中的 XIIa 因子。具有选择性、ATP 竞争性酪蛋白激酶 2 (CK2) 抑制剂（K i = 20 nM）。具有多种生物活性，包括抗氧化、抗增殖和促凋亡活性。
应用 常见于多酚植物。谷胱甘肽S-转移酶的抑制剂，常用于检测血浆中XIIa 因子；抗氧化剂；DNA双链的保护剂。
储存温度 2-8°C储存,避光,充氩
运输条件 冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

鞣花酸是在多种水果和蔬菜中天然生成的酚酸类次级植物代谢物，通常存在于绿茶、石榴、草莓、树莓和核桃中。

Ellagic acid is a naturally occurring phenolic acid in many fruits and vegetables, as a secondary plant metabolite.It is commonly found in green tea, pomegranate, strawberries, blackberries, raspberries, and walnuts.
纯度 ≥96%

关联靶点（人）

GPR35 Tchem G蛋白偶联受体35(G-protein coupled receptor 35) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ELAVL3 Tchem 类禽流感病毒蛋白 3(ELAV-like protein 3) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CSNK2A1 Tchem 酪蛋白激酶 II 亚基 α(Casein kinase II subunit alpha) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
POLH Tchem DNA聚合酶(DNA polymerase eta) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
SLC22A6 Tclin 溶质载体家族 22 成员 6(Solute carrier family 22 member 6) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
HSPA1A Tchem 热休克 70 kDa 蛋白 1A(Heat shock 70 kDa protein 1A) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
SMAD3 Tchem 母亲反对 decapentaplegic 同源物 3(Mothers against decapentaplegic homolog 3) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
POLI Tchem DNA聚合酶iota(DNA polymerase iota) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
AKR1B1 Tclin 醛糖还原酶(Aldose reductase) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GALNT2 Tchem 多肽N-乙酰半乳糖氨基转移酶2(Polypeptide N-acetylgalactosaminyltransferase 2) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
VDR Tclin Vitamin D receptor (26531 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IGF1R Tclin Insulin-like growth factor I receptor (8605 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AKR1B1 Tclin Aldose reductase (1404 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CSNK2A1 Tchem Casein kinase II alpha (3512 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA3 Tclin Carbonic anhydrase III (753 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA6 Tclin Carbonic anhydrase VI (993 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA1 Tclin Carbonic anhydrase I (13240 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MIF Tchem Macrophage migration inhibitory factor (979 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLB Tchem DNA polymerase beta (23632 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALDOA Tbio Fructose-bisphosphate aldolase A (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SRC Tclin Tyrosine-protein kinase SRC (10310 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
APP Tclin Amyloid-beta A4 protein (8510 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IKBKB Tchem Inhibitor of nuclear factor kappa B kinase beta subunit (5554 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CSK Tchem Tyrosine-protein kinase CSK (2395 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SYK Tclin Tyrosine-protein kinase SYK (7372 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA5B Tclin Carbonic anhydrase VB (957 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA5A Tclin Carbonic anhydrase VA (1168 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA14 Tclin Carbonic anhydrase XIV (1305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DUSP3 Tchem Dual specificity protein phosphatase 3 (1161 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTK2 Tclin Focal adhesion kinase 1 (4730 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GSTP1 Tchem Glutathione S-transferase Pi (449 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MET Tclin Hepatocyte growth factor receptor (10718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HBB Tbio Hemoglobin beta chain (329 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EPHX2 Tchem Epoxide hydratase (3844 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FLT4 Tclin Vascular endothelial growth factor receptor 3 (3216 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GAPDH Tchem Glyceraldehyde-3-phosphate dehydrogenase liver (1284 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LYN Tclin Tyrosine-protein kinase Lyn (4251 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SPHK1 Tchem Sphingosine kinase 1 (1990 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TOP2B Tclin DNA topoisomerase II beta (959 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DYRK1A Tchem Dual-specificity tyrosine-phosphorylation regulated kinase 1A (6484 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA12 Tclin Carbonic anhydrase XII (6231 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BACE1 Tchem Beta-secretase 1 (15641 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GSR Tclin Glutathione reductase (335 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AKT1 Tchem Serine/threonine-protein kinase AKT (9192 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

ERG1 Squalene monooxygenase (20 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pol Human immunodeficiency virus type 1 reverse transcriptase (18245 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ampC Beta-lactamase AmpC (62480 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
tat Human immunodeficiency virus type 1 Tat protein (75 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ca7 Carbonic anhydrase VII (3 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cruzipain (33337 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ca13 Carbonic anhydrase XIII (322 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA4 Carbonic anhydrase IV (1713 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ENTPD1 Ectonucleoside triphosphate diphosphohydrolase 1 (16 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pol Human immunodeficiency virus type 1 integrase (9041 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ralstonia solanacearum (520 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Salmonella typhimurium (15756 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Porphyromonas gingivalis (651 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus epidermidis (22802 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Streptococcus mutans (2687 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Actinomyces viscosus (309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium berghei (192651 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Caenorhabditis elegans (1055 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Stenotrophomonas maltophilia (1743 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
3T3-L1 (3664 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
B16 (5829 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Vero (26788 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
L6 (7924 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Salmon testes DNA (254 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TRXR Thioredoxin reductase (20 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
lef Anthrax lethal factor (7585 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Dusp6 Dual specificity protein phosphatase 6 (459 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Carm1 Histone-arginine methyltransferase CARM1 (53 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Luciferin 4-monooxygenase (66902 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slc22a6 Solute carrier family 22 member 6 (141 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pectobacterium carotovorum (295 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium vinckei petteri (380 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Prevotella intermedia (369 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Eif4e Eukaryotic translation initiation factor 4E (654 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 207-508-3
分子类型 小分子
IIUPAC Name 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione
INCHI 1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H
InChi Key AFSDNFLWKVMVRB-UHFFFAOYSA-N
Smiles C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O
Isomeric SMILES C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O
分子量 302.19
Beilstein号 47549
Reaxy-Rn 47549
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=47549&ln=

化学和物理性质

溶解性 Slightly soluble in water. Soluble in 1M sodium hydroxide (10 mg/ml), EtOH, and pyridine.
密度 1.667
敏感性 对空气敏感，对光敏感，对湿度敏感
熔点 360°C
分子量 302.190 g/mol
XLogP3 1.100
氢键供体数Hydrogen Bond Donor Count 4
氢键受体数Hydrogen Bond Acceptor Count 8
可旋转键计数Rotatable Bond Count 0
精确质量Exact Mass 302.006 Da
单同位素质量Monoisotopic Mass 302.006 Da
拓扑极表面积Topological Polar Surface Area 134.000 Ų
重原子数Heavy Atom Count 22
形式电荷Formal Charge 0
复杂度Complexity 475.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P302+P352: 如皮肤沾染：用水充分清洗。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P405: 密闭存放

P403+P233: 存放在通风良好的地方。保持容器密闭。

P501: 将内容物/容器处理到。。。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany 3
RTECS DJ2620000
Merck Index 3547
个人防护装备 dust mask type N95 (US),Eyeshields,Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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18. N Al-Kharusi,H A Babiker,S Al-Salam,M I Waly,A Nemmar,I Al-Lawati,J Yasin,S Beegam,B H Ali.  (2013-02-22)  Ellagic acid protects against cisplatin-induced nephrotoxicity in rats: a dose-dependent study..  European review for medical and pharmacological sciences,  17  ((3)): (299-310).  [PMID:23426532]
19. H Nasri.  (2013-04-24)  Ellagic acid protects against cisplatin-induced nephrotoxicity in rats: a dose-dependent study..  European review for medical and pharmacological sciences,  17  ((6)): (849-850).  [PMID:23609372]
20. Aleksandra Owczarek,Jan Gudej.  (2013-04-25)  Investigation into biologically active constituents of Geum rivale L..  Acta poloniae pharmaceutica,  70  ((1)): (111-114).  [PMID:23610965]
21. Min Zhao,Su-Ni Tang,Justin L Marsh,Sharmila Shankar,Rakesh K Srivastava.  (2013-05-21)  Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice..  Cancer letters,  337  ((2)): (210-217).  [PMID:23684930]
22. Coskun Usta,Semir Ozdemir,Michele Schiariti,Paolo Emilio Puddu.  (2013-05-25)  The pharmacological use of ellagic acid-rich pomegranate fruit..  International journal of food sciences and nutrition,  64  ((7)): (907-913).  [PMID:23700985]
23. Rocío García-Villalba,David Beltrán,Juan Carlos Espín,María Victoria Selma,Francisco A Tomás-Barberán.  (2013-08-30)  Time course production of urolithins from ellagic acid by human gut microbiota..  Journal of agricultural and food chemistry,  61  ((37)): (8797-8806).  [PMID:23984796]
24. Sonia Trombino,Teresa Ferrarelli,Michele Pellegrino,Emilia Ricchio,Loredana Mauro,Sebastiano Andò,Nevio Picci,Roberta Cassano.  (2013-11-14)  Anticancer activity of a hydrogel containing folic acid towards MCF-7 and MDA-MB-231 cells..  Anticancer research,  33  ((11)): (4847-4854).  [PMID:24222122]
25. Jatinder Rana,Ganesh Diwakar,Lisa Saito,Jeffrey D Scholten,Timothy Mulder.  (2014-01-09)  Inhibition of melanin content by Punicalagins in the super fruit pomegranate (Punica granatum)..  Journal of cosmetic science,  64  ((6)): (445-453).  [PMID:24397882]
26. Jung-Heun Ha,Pollob Kumar Shil,Ping Zhu,Liwei Gu,Qiuhong Li,Soonkyu Chung.  (2014-04-05)  Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium cells and in C57BL/6 mice..  The Journal of nutrition,  144  ((6)): (799-806).  [PMID:24699803]
27. Lina Raudone,Ramune Bobinaite,Valdimaras Janulis,Pranas Viskelis,Sonata Trumbeckaite.  (2014-04-05)  Effects of raspberry fruit extracts and ellagic acid on respiratory burst in murine macrophages..  Food & function,  5  ((6)): (1167-1174).  [PMID:24699912]
28. Andreia R H da Silva,Laís da R Moreira,Evelyne da S Brum,Mayara L de Freitas,Aline A Boligon,Margareth L Athayde,Silvane S Roman,Cinthia M Mazzanti,Ricardo Brandão.  (2014-04-08)  Biochemical and hematological effects of acute and sub-acute administration to ethyl acetate fraction from the stem bark Scutia buxifolia Reissek in mice..  Journal of ethnopharmacology,  153  ((3)): (908-916).  [PMID:24704489]
29. Tomoaki Haraguchi,Tomoko Kayashima,Yukako Okazaki,Junji Inoue,Shigeru Mineo,Kiminori Matsubara,Ei Sakaguchi,Noriyuki Yanaka,Norihisa Kato.  (2014-05-27)  Cecal succinate elevated by some dietary polyphenols may inhibit colon cancer cell proliferation and angiogenesis..  Journal of agricultural and food chemistry,  62  ((24)): (5589-5594).  [PMID:24856584]
30. Lorena Trigueros,Aneta Wojdyło,Esther Sendra.  (2014-06-19)  Antioxidant activity and protein-polyphenol interactions in a pomegranate (Punica granatum L.) yogurt..  Journal of agricultural and food chemistry,  62  ((27)): (6417-6425).  [PMID:24939339]
31. Ana Oliveira,Elisabete M C Alexandre,Marta Coelho,Cláudia Lopes,Domingos P F Almeida,Manuela Pintado.  (2014-10-14)  Incorporation of strawberries preparation in yoghurt: impact on phytochemicals and milk proteins..  Food chemistry,  171  (370-378).  [PMID:25308682]
32. Bing Tang,Guang-xian Chen,Meng-ya Liang,Jian-ping Yao,Zhong-kai Wu.  (2014-12-02)  Ellagic acid prevents monocrotaline-induced pulmonary artery hypertension via inhibiting NLRP3 inflammasome activation in rats..  International journal of cardiology,  180  (134-141).  [PMID:25438234]
33. C Kluft,C J M van Leuven.  (2014-12-04)  Consequences for the APTT due to direct action of factor XIa on factor X, resulting in bypassing factors VIII-IX..  Thrombosis research,  135  ((1)): (198-204).  [PMID:25467084]
34. Yoshiyuki Morishima,Chikako Kamisato.  (2015-01-18)  Laboratory measurements of the oral direct factor Xa inhibitor edoxaban: comparison of prothrombin time, activated partial thromboplastin time, and thrombin generation assay..  American journal of clinical pathology,  143  ((2)): (241-247).  [PMID:25596250]
35. Vivian Caetano Bochi,Helena Teixeira Godoy,M Monica Giusti.  (2015-01-28)  Anthocyanin and other phenolic compounds in Ceylon gooseberry (Dovyalis hebecarpa) fruits..  Food chemistry,  176  (234-243).  [PMID:25624229]
36. Yaghoob Farbood,Alireza Sarkaki,Mahin Dianat,Ali Khodadadi,Mohammad Khaksari Haddad,Shahram Mashhadizadeh.  (2015-02-01)  Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury..  Life sciences,  124  (120-127).  [PMID:25637685]
37. Saar Aharoni,Yoni Lati,Michael Aviram,Bianca Fuhrman.  (2015-02-05)  Pomegranate juice polyphenols induce a phenotypic switch in macrophage polarization favoring a M2 anti-inflammatory state..  BioFactors (Oxford, England),  41  ((1)): (44-51).  [PMID:25650983]
38. Shubhankar Das,Rishikesh Kumar,Bola Sadashiva Satish Rao.  (2015-04-17)  Radio-modifying potential of Saraca indica against ionizing radiation: an in vitro study using Chinese hamster lung fibroblast (V79) cells..  Cell biology international,  39  ((9)): (1061-1072).  [PMID:25879585]
39. Bradley W Bolling,Rod Taheri,Ruisong Pei,Sarah Kranz,Mo Yu,Shelley N Durocher,Mark H Brand.  (2015-05-16)  Harvest date affects aronia juice polyphenols, sugars, and antioxidant activity, but not anthocyanin stability..  Food chemistry,  187  (189-196).  [PMID:25977015]
40. Ammar Altemimi,Dennis G Watson,Mary Kinsel,David A Lightfoot.  (2015-06-25)  Simultaneous extraction, optimization, and analysis of flavonoids and polyphenols from peach and pumpkin extracts using a TLC-densitometric method..  Chemistry Central journal,  9  (39-39).  [PMID:26106445]
41. Rocío García-Villalba,Juan Carlos Espín,Kjersti Aaby,Cesarettin Alasalvar,Marina Heinonen,Griet Jacobs,Stefan Voorspoels,Tuuli Koivumäki,Paul A Kroon,Ebru Pelvan,Shikha Saha,Francisco A Tomás-Barberán.  (2015-07-15)  Validated Method for the Characterization and Quantification of Extractable and Nonextractable Ellagitannins after Acid Hydrolysis in Pomegranate Fruits, Juices, and Extracts..  Journal of agricultural and food chemistry,  63  ((29)): (6555-6566).  [PMID:26158321]
42. Jieping Yang,Rupo Lee,Susanne M Henning,Gail Thames,Mark Hsu,Hei ManLam,David Heber,Zhaoping Li.  (2015-10-17)  Soy protein isolate does not affect ellagitannin bioavailability and urolithin formation when mixed with pomegranate juice in humans..  Food chemistry,  194  (1300-1303).  [PMID:26471685]
43. Su Jin Kang,Beom Rak Choi,Eun Kyoung Lee,Seung Hee Kim,Hae Yeon Yi,Hye Rim Park,Chang Hyun Song,Young Joon Lee,Sae Kwang Ku.  (2015-10-17)  Inhibitory Effect of Dried Pomegranate Concentration Powder on Melanogenesis in B16F10 Melanoma Cells; Involvement of p38 and PKA Signaling Pathways..  International journal of molecular sciences,  16  ((10)): (24219-24242).  [PMID:26473849]
44. Shuqin Mao,Fei Zhou,Weisu Huang,Baiyi Lu,Jiajia Yang,Lilin He,Yiying Zhao.  (2015-10-29)  The effect of traditional stir-frying process on hydrophilic and lipophilic antioxidant capacities of pine nut kernels..  International journal of food sciences and nutrition,  66  ((8)): (873-880).  [PMID:26507566]
45. Bahaderjeet Singh,Prince Sharma,Arun Kumar,Pooja Chadha,Ramandeep Kaur,Amarjeet Kaur.  (2016-10-11)  Antioxidant and in vivo genoprotective effects of phenolic compounds identified from an endophytic Cladosporium velox and their relationship with its host plant Tinospora cordifolia..  Journal of ethnopharmacology,  194  (450-456).  [PMID:27721051]
46. Hyun Jik Lee,Young Hyun Jung,Gee Euhn Choi,Jun Sung Kim,Chang Woo Chae,Jae Ryong Lim,Seo Yihl Kim,Jee Hyeon Yoon,Ji Hyeon Cho,Sei-Jung Lee,Ho Jae Han.  (2020-07-25)  Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis..  Cell death and differentiation,  28  ((1)): (184-202).  [PMID:32704090]
47. Saritha Marella,Kanipakam Hema,Syed Shameer,T N V K V Prasad.  (2020-10-02)  Nano-ellagic acid: inhibitory actions on aldose reductase and α-glucosidase in secondary complications of diabetes, strengthened by in silico docking studies..  3 Biotech,  10  ((10)): (439-439).  [PMID:32999815]
48. Paula Aranaz,David Navarro-Herrera,María Zabala,Ana Romo-Hualde,Miguel López-Yoldi,José Luis Vizmanos,Fermín I Milagro,Carlos J González-Navarro.  (2020-11-05)  Phenolic Compounds Reduce the Fat Content in Caenorhabditis elegans by Affecting Lipogenesis, Lipolysis, and Different Stress Responses..  Pharmaceuticals (Basel, Switzerland),  13  ((11)): [PMID:33143060]
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51. Adriana Chilin,Roberto Battistutta,Andrea Bortolato,Giorgio Cozza,Samuele Zanatta,Giorgia Poletto,Marco Mazzorana,Giuseppe Zagotto,Eugenio Uriarte,Adriano Guiotto,Lorenzo A Pinna,Flavio Meggio,Stefano Moro.  (2008-02-07)  Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships..  Journal of medicinal chemistry,  51  ((4)): (752-759).  [PMID:18251491]
52. Yusuke Sekiguchi,Tetsuko Nakaniwa,Takayoshi Kinoshita,Isao Nakanishi,Kazuo Kitaura,Akira Hirasawa,Gozoh Tsujimoto,Toshiji Tada.  (2009-05-06)  Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid..  Bioorganic & medicinal chemistry letters,  19  ((11)): (2920-2923).  [PMID:19414254]
53. Rocío González-Barrio,Gina Borges,William Mullen,Alan Crozier.  (2010-03-12)  Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy..  Journal of agricultural and food chemistry,  58  ((7)): (3933-3939).  [PMID:20218618]
54. Valentina Furlanetto,Giuseppe Zagotto,Riccardo Pasquale,Stefano Moro,Barbara Gatto.  (2012-08-29)  Ellagic acid and polyhydroxylated urolithins are potent catalytic inhibitors of human topoisomerase II: an in vitro study..  Journal of agricultural and food chemistry,  60  ((36)): (9162-9170).  [PMID:22924519]
55. Patrice Njomnang Soh,Benoit Witkowski,Amandine Gales,Eric Huyghe,Antoine Berry,Bernard Pipy,Françoise Benoit-Vical.  (2012-10-03)  Implication of glutathione in the in vitro antiplasmodial mechanism of action of ellagic acid..  PloS one,  7  ((9)): (e45906-e45906).  [PMID:23029306]
56. Ting-Yu Kao,Yuan-Chiang Chung,Yung-Chi Hou,Yin-Wen Tsai,Chin-Hui Chen,Hsin-Ping Chang,Jui-Ling Chou,Chih-Ping Hsu.  (2012-10-13)  Effects of ellagic acid on chemosensitivity to 5-fluorouracil in colorectal carcinoma cells..  Anticancer research,  32  ((10)): (4413-4418).  [PMID:23060566]
57. Shuang Zhang,Xin Liu,Zi-Long Zhang,Lu He,Zhe Wang,Guang-Shu Wang.  (2012-11-28)  Isolation and identification of the phenolic compounds from the roots of Sanguisorba officinalis L. and their antioxidant activities..  Molecules (Basel, Switzerland),  17  ((12)): (13917-13922).  [PMID:23178307]
58. Amanda Dahl,Margarita Yatskayer,Susana Raab,Christian Oresajo.  (2013-02-05)  Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone..  Journal of drugs in dermatology : JDD,  12  ((1)): (52-58).  [PMID:23377328]
59. Bin Li,Kim Harich,Lindsay Wegiel,Lynne S Taylor,Kevin J Edgar.  (2013-02-13)  Stability and solubility enhancement of ellagic acid in cellulose ester solid dispersions..  Carbohydrate polymers,  92  ((2)): (1443-1450).  [PMID:23399175]
60. Yukihiro Yoshimura,Saori Nishii,Nobuhiro Zaima,Tatsuya Moriyama,Yukio Kawamura.  (2013-04-16)  Ellagic acid improves hepatic steatosis and serum lipid composition through reduction of serum resistin levels and transcriptional activation of hepatic ppara in obese, diabetic KK-A(y) mice..  Biochemical and biophysical research communications,  434  ((3)): (486-491).  [PMID:23583377]
61. V Arulmozhi,K Pandian,S Mirunalini.  (2013-06-05)  Ellagic acid encapsulated chitosan nanoparticles for drug delivery system in human oral cancer cell line (KB)..  Colloids and surfaces. B, Biointerfaces,  110  (313-320).  [PMID:23732810]
62. Inhae Kang,Meshail Okla,Soonkyu Chung.  (2014-06-16)  Ellagic acid inhibits adipocyte differentiation through coactivator-associated arginine methyltransferase 1-mediated chromatin modification..  The Journal of nutritional biochemistry,  25  ((9)): (946-953).  [PMID:24929439]
63. Irwin R A Menezes,Temístocles I Santana,Victor J C Varela,Rogerio A Saraiva,Edinardo F F Matias,Aline A Boligon,Margareth L Athayde,Henrique D M Coutinho,Jose G M Costa,João B T Rocha.  (2014-09-27)  Chemical composition and evaluation of acute toxicological, antimicrobial and modulatory resistance of the extract of Murraya paniculata..  Pharmaceutical biology,  53  ((2)): (185-191).  [PMID:25255929]
64. María Eva González-Trujano,Francisco Pellicer,Pedro Mena,Diego A Moreno,Cristina García-Viguera.  (2015-03-31)  Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins..  International journal of food sciences and nutrition,  66  ((4)): (395-399).  [PMID:25822007]
65. Jenny Björkqvist,Steven de Maat,Urs Lewandrowski,Antonio Di Gennaro,Chris Oschatz,Kai Schönig,Markus M Nöthen,Christian Drouet,Hal Braley,Marc W Nolte,Albert Sickmann,Con Panousis,Coen Maas,Thomas Renné.  (2015-07-21)  Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III..  The Journal of clinical investigation,  125  ((8)): (3132-3146).  [PMID:26193639]
66. Huaxin Song,Liuquan Zhang,Lipeng Wu,Weisu Huang,Mengmeng Wang,Liangxiao Zhang,Yafang Shao,Meng Wang,Fang Zhang,Ziyan Zhao,Xiaohong Mei,Tao Li,Donghui Wang,Ying Liang,Jing Li,Tao Xu,Yajing Zhao,Yongheng Zhong,Qi Chen,Baiyi Lu.  (2020-04-03)  Phenolic acid profiles of common food and estimated natural intake with different structures and forms in five regions of China..  Food chemistry,  321  (126675-126675).  [PMID:32240915]
67. Zonne L M Hofman,Chantal C Clark,C Erik Hack,Steven de Maat,Coen Maas.  (2020-05-04)  Detecting oral kallikrein-targeting therapy through triggered contact activation: A\xa0phase I study..  The Journal of allergy and clinical immunology,  146  ((6)): (1446-1449).  [PMID:32360287]
68. Agnieszka Milczarek,Michał Sójka,Robert Klewicki.  (2020-12-05)  Transfer of ellagitannins to unclarified juices and purees in the processing of selected fruits of the Rosaceae family..  Food chemistry,  344  (128684-128684).  [PMID:33272756]
69. Shuaijun Lu, Hailong Tian, Bowen Li, Lei Li, Hao Jiang, Yajie Gao, Lin Zheng, Canhua Huang, Yuping Zhou, Zhongyan Du, Jia Xu.  (2023)  An Ellagic Acid Coordinated Copper-Based Nanoplatform for Efficiently Overcoming Cancer Chemoresistance by Cuproptosis and Synergistic Inhibition of Cancer Cell Stemness.  Small,  (2309215).  [PMID:38044295] [10.1002/smll.202309215]
70. Edidiong Joseph Bassey, Jun-Hu Cheng, Da-Wen Sun.  (2024)  Comparative elucidation of bioactive and antioxidant properties of red dragon fruit peel as affected by electromagnetic and conventional drying approaches.  FOOD CHEMISTRY,  439  (138118).  [PMID:38109834] [10.1016/j.foodchem.2023.138118]
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