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丹磺酰氯

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货号 (SKU) 包装规格 是否现货 价格 数量
D755545-1g
1g 现货 Stock Image
D755545-5g
5g 现货 Stock Image
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磺酰氯 (11)

基本描述

别名 1-二甲基氨基萘-5-磺酰氯 | 氯化二硝基水杨酸 | 5-(二甲基氨基)萘-1-磺酰氯
规格或纯度 BioReagent, 适用于荧光分析, ≥99%(HPLC)
英文名称 Dansyl chloride
储存温度 2-8°C储存,避光,充氩
运输条件 冰袋运输
产品介绍

丹磺酰氯用作衍生化试剂,用于临床前研究研究乙炔雌二醇的大量代谢和最低给药剂量。 使用丹磺酰氯获得衍生物通过HPLC方法测定人血清中双酚的研究。 丹磺酰氯衍生物适用于LC/MS测定和表征食品样品中草甘膦、氨甲基膦酸(AMPA)和草铵膦 。一种用于氨基酸和肽的荧光N-末端衍生化的荧光试剂,并且可用反相HPLC进行检测。应用:

丹磺酰氯又称5-二甲基氨基萘-1-磺酰氯,是一种柱前衍生化试剂。 衍生化反应后,荧光衍生物可使用NMR、IR、UV-vis和荧光显微镜等多种分析方法分析。丹磺酰氯是一种典型的芳香族磺酰氯,它与各种碱反应,生成具有不同稳定性的衍生物。

Dansyl Chloride, also known as 5-dimethylamino naphthalene-1-sulfonyl chloride, is a pre-column derivatization reagent. After the derivatization reaction, the fluorescent derivatives are analyzed using several analytical methods like NMR, IR, UV-vis, and fluorescence microscopy. Dansyl Chloride is a typical aromatic sulphonyl chloride that reacts with various bases, resulting in derivatives with variable stability.

Application:

Dansyl Chloride is used as a derivatization reagent to study extensive metabolism and low doses of ethinylestradiol administered during pre-clinical studies. Studies conducted to determine bisphenols in human serum through the HPLC method used Dansyl Chloride to obtain the derivative products. Dansyl Chloride derivatives are suitable for LC/MS determination and characterization of glyphosate, aminomethylphosphonic acid (AMPA), and glufosinate from food samples.
A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.
纯度 ≥99%(HPLC)

名称和识别符

分子类型 未知
IIUPAC Name 5-(dimethylamino)naphthalene-1-sulfonyl chloride
INCHI 1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3
InChi Key XPDXVDYUQZHFPV-UHFFFAOYSA-N
Smiles CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)Cl
Isomeric SMILES CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)Cl
分子量 269.74
Reaxy-Rn 2217205
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2217205&ln=

化学和物理性质

溶解性 acetone: 0.2 g/10 mL
敏感性 对光敏感;对湿度敏感
比旋光度 1.64
沸点 371.30 °C at 760 mmHg
熔点 69-73°C
分子量 269.750 g/mol
XLogP3 3.500
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 269.028 Da
单同位素质量Monoisotopic Mass 269.028 Da
拓扑极表面积Topological Polar Surface Area 45.800 Ų
重原子数Heavy Atom Count 17
形式电荷Formal Charge 0
复杂度Complexity 363.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性(GHS)

象形图 GHS05
信号词 危险
危险声明

H314: 造成严重的皮肤灼伤和眼睛损伤

预防措施声明

P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。

P264: 处理后要彻底洗手。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理(请参阅此标签上的...)。

P363: 再次使用之前,请清洗受污染的衣物。

P301+P330+P331: 如误吞咽:漱口。不要诱导呕吐。

P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。

P405: 密闭存放

P501: 将内容物/容器处理到。。。

P305+P354+P338: 如果进入眼睛:立即用水冲洗几分钟。取下隐形眼镜(如果有的话),并且操作简单。继续冲洗。

P302+P361+P354: 如果接触皮肤:立即脱掉所有被污染的衣服。立即用水冲洗几分钟。

P316: 立即寻求紧急医疗救助。

RTECS QK3688000
Merck Index 2814

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批号(Lot Number) 证书类型 货号
I2515029 分析证书 D755545
I2515081 分析证书 D755545
G2524022 分析证书 D755545
D2503002 分析证书 D755545
D2503003 分析证书 D755545

此产品的引用文献

引用文献

1. Yujing Zhou, Jue Xu, Xiankang Fan, Qiang Xia, Changyu Zhou, Yangyang Hu, Hongbing Yan, Yangying Sun, Daodong Pan.  (2025)  Effect of pulsed electric field pretreatment synergistic mixed bacterial agent fermentation on the flavor and quality of air-dried goose meat and its molecular mechanism.  POULTRY SCIENCE,  (104926).  [PMID:40014970] [10.1016/j.psj.2025.104926]
2. Yumeng Sui, Jiasheng Lu, Ying-ao Zhu, Baohua Kong, Hui Wang, Ligang Qin, Qian Chen.  (2024)  Effects of exogenous autoinducer-2 precursor on the ability of Lactiplantibacillus plantarum SH7 to degrade biogenic amines: In vitro and in a dry-sausage model.  Food Bioscience,  60  (104263).  [10.1016/j.fbio.2024.104263]
3. Niuniu Bai, Jianlin He, Bihong Hong, Zelong Wu, Liping Wang, Zongze Shao.  (2025)  Fast Preparation of Fish Sauce Treated With Marine Protease-Producing Bacillus zhangzhouensis sp..  JOURNAL OF FOOD PROCESSING AND PRESERVATION,  2025  (1): (6298724).  [10.1155/jfpp/6298724]
4. Xiaoyu Xie, Xiuqiong Zhang, Tiantian Chen, Di Yu, Ming Ma, Xin Lu, Guowang Xu.  (2024)  High-coverage identification of hydroxyl compounds based on pyridine derivatization-assisted liquid chromatography mass spectrometry.  ANALYTICA CHIMICA ACTA,  1322  (343065).  [PMID:39182991] [10.1016/j.aca.2024.343065]
5. Yujing Zhou, Jue Xu, Xiankang Fan, Zihang Shi, Wei Wang, Ming Huang, Kaiyong Yao, Hongbing Yan, Changyu Zhou, Yangyang Hu, Daodong Pan.  (2025)  Pulsed electric field assisted mixed bacteria to efficiently control biogenic amines in air-dried goose.  Food Bioscience,  64  (105935).  [10.1016/j.fbio.2025.105935]
6. Wenjing Liu, Xiaoxiang Hu, Yi Yan, Yujie Cai.  (2024)  Rational engineering of homospermidine synthase for enhanced catalytic efficiency toward spermidine synthesis.  Synthetic and Systems Biotechnology,  (549).  [PMID:38699566] [10.1016/j.synbio.2024.04.012]
7. Lichen Gou, Ling Li, Siqi Wei, Yunfei Tian, Xiandeng Hou, Li Wu.  (2024)  Sensitive detection of histamine utilizing the SERS platform combined with an azo coupling reaction and a composite hydrophobic layer.  TALANTA,  278  (126531).  [PMID:39002262] [10.1016/j.talanta.2024.126531]

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