丹酰氯（DNSCl）

荧光伯胺反应试剂。

34篇引用文献

COA

级别和纯度:

Moligand™

≥98%(HPLC)

CAS编号: 605-65-2
分子式: C₁₂H₁₂ClNO₂S
分子量: 269.74
MDL号: MFCD00003985
PubChem编号: 11801

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货号 (SKU)	包装规格	是否现货
D133513-250mg	250mg	现货
D133513-1g	1g	现货
D133513-5g	5g	现货
D133513-10g	10g	现货
D133513-25g	25g	现货
D133513-100g	100g	现货

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Fluorescent Dye (370) 化学生物学 (1256) 糖科学 (92) 酰氯 (15)

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基本描述

别名	丹磺酰氯 \| 5-(二甲氨基)萘-1-磺酰氯
英文别名	1-Chlorosulfonyl-5-dimethylaminonaphthalene \| CHEBI:51907 \| DNS chloride \| DNSClDNSCl \| AM10162 \| QMU9166TJ4 \| Q409512 \| 5-dimethylaminonaphthalenesulfonyl chloride \| 1-NAPHTHALENESULFONYL CHLORIDE, 5-(DIMETHYLAMINO)- \| 5-Dimethylaminonaphthyl-5-sulfonyl
规格或纯度	Moligand™, ≥98%(HPLC)
英文名称	Dansyl Chloride（DNSCl）
生化机理	用于氨基酸和多肽N末端衍生化的荧光伯胺反应试剂，以及通过反相HPLC和其他分析程序检测多胺的试剂。
储存温度	2-8°C储存,避光,充氩
运输条件	冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	丹磺酰氯又称5-二甲基氨基萘-1-磺酰氯，是一种柱前衍生化试剂。衍生化反应后，荧光衍生物可使用NMR、IR、UV-vis和荧光显微镜等多种分析方法分析。丹磺酰氯是一种典型的芳香族磺酰氯，它与各种碱反应，生成具有不同稳定性的衍生物。应用一种用于氨基酸和肽的荧光N-末端衍生化的荧光试剂，并且可用反相HPLC进行检测。丹磺酰氯用作衍生化试剂，用于临床前研究研究乙炔雌二醇的大量代谢和最低给药剂量。使用丹磺酰氯获得衍生物通过HPLC方法测定人血清中双酚的研究。丹磺酰氯衍生物适用于LC/MS测定和表征食品样品中草甘膦、氨甲基膦酸(AMPA)和草铵膦。 Dansyl Chloride, also known as 5-dimethylamino naphthalene-1-sulfonyl chloride, is a pre-column derivatization reagent. After the derivatization reaction, the fluorescent derivatives are analyzed using several analytical methods like NMR, IR, UV-vis, and fluorescence microscopy. Dansyl Chloride is a typical aromatic sulphonyl chloride that reacts with various bases, resulting in derivatives with variable stability.
纯度	≥98%(HPLC)

名称和识别符

分子类型	小分子
IIUPAC Name	5-(dimethylamino)naphthalene-1-sulfonyl chloride
INCHI	1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3
InChi Key	XPDXVDYUQZHFPV-UHFFFAOYSA-N
Smiles	CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)Cl
Isomeric SMILES	CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)Cl
分子量	269.74
Reaxy-Rn	2217205
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2217205&ln=

化学和物理性质

溶解性	Soluble in DMF, acetone (50 mg/ml), chloroform, pyridine, benzene, and dioxane. Insoluble in water；Insoluble in water，Soluble in acetone、 chloroform、benzene
敏感性	对湿度敏感、对光线敏感、对热敏感
比旋光度	1.64
沸点	371.30 °C at 760 mmHg
熔点	69-73°C
分子量	269.750 g/mol
XLogP3	3.500
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	3
可旋转键计数Rotatable Bond Count	2
精确质量Exact Mass	269.028 Da
单同位素质量Monoisotopic Mass	269.028 Da
拓扑极表面积Topological Polar Surface Area	45.800 Å²
重原子数Heavy Atom Count	17
形式电荷Formal Charge	0
复杂度Complexity	363.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS05
信号词	危险
危险声明	H290: 可能腐蚀金属 H314: 造成严重的皮肤灼伤和眼睛损伤
预防措施声明	P234: 仅保存在原始容器中 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P264: 处理后要彻底洗手。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P363: 再次使用之前，请清洗受污染的衣物。 P390: 吸收溢出物以防止材料损坏。 P301+P330+P331: 如误吞咽：漱口。不要诱导呕吐。 P303+P361+P353: 如皮肤（或头发）沾染：立即脱掉所有沾染的衣服。用水清洗皮肤/淋浴。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P405: 密闭存放 P406: 存放在带有耐腐蚀内衬的耐腐蚀/ ...容器中。 P501: 将内容物/容器处理到。。。
RTECS	QK3688000
Merck Index	2814

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A2402152	分析证书	D133513
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C2315273	分析证书	D133513
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引用文献

1. Shijin Xiong, Xiaoyan Xu, Qiaozhen Liu, Yazhou Xu, Hongbing Ren, Tao Xiong, Mingyong Xie. (2024) Integrated metatranscriptomics and metabolomics revealed the metabolic pathways of biogenic amines during Laotan Suancai fermentation. Food Bioscience, 57 (103517). [10.1016/j.fbio.2023.103517]
2. Chen Chen, Yingfang Zhang, Ximo Wang, Xuguang Qiao, Geoffrey I.N. Waterhouse, Zhixiang Xu. (2024) A core-satellite self-assembled SERS aptasensor containing a “biological-silent region” Raman tag for the accurate and ultrasensitive detection of histamine. Food Science and Human Wellness, 13 (1029). [10.26599/FSHW.2022.9250089]
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4. Furong Jin, Xinyue Yin, Yang Wan, Jiukai Zhang, Jindi Wang, Xiangbo Fu, Tianxin Fu, Buwei Liu, Yongshi Chen, Bo Tian, Zhibiao Feng. (2023) Ultrasonic–microwave synergistic supramolecular solvent liquid–liquid microextraction of trace biogenic amines in fish and beer based on solidification of floating organic droplet. FOOD CHEMISTRY, 429 (136965). [PMID:37516607] [10.1016/j.foodchem.2023.136965]
5. Jianghua Chen, Yuanshuai Zang, Mengyi Chen, Chen Shi, Manlei Zhang, Bin Di, Cheng Jiang. (2023) Sensitive determination of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in wastewater by solid-phase extraction with pre-column derivatization and liquid chromatography-tandem mass spectrometry. Analytical Methods, 15 (21): (2693-2699). [PMID:37226492] [10.1039/D3AY00420A]
6. Shan Xu, Peifang Chen, Xichi Lin, Imran Mahmood Khan, Xiaoyuan Ma, Zhouping Wang. (2023) Controllable synthesis of flower-like AuNFs@ZIF-67 core-shell nanocomposites for ultrasensitive SERS detection of histamine in fish. ANALYTICA CHIMICA ACTA, 1240 (340776). [PMID:36641156] [10.1016/j.aca.2022.340776]
7. Jian-Jun Zhong, Liping Xia, Liuru Xue, Boyu Liu, Lingling Zhao, Hua Ye, Zhanming Li. (2023) Analytical method for histamine, urocanic acid isomers, and their precursor histidine in fish sauce based on precolumn dansylation and high-performance liquid chromatography. FOOD CONTROL, 147 (109566). [10.1016/j.foodcont.2022.109566]
8. Yixuan Fan, Runze Yu, Yongfeng Chen, Yufeng Sun, Geoffrey I. N. Waterhouse, Zhixiang Xu. (2022) A Capillary Electrophoresis Method Based on Molecularly Imprinted Solid-Phase Extraction for Selective and Sensitive Detection of Histamine in Foods. MOLECULES, 27 (20): (6987). [PMID:36296580] [10.3390/molecules27206987]
9. Xirui Chen, Yujie Tu, Song Cheng, Xujing Guo, Tianying Lu, Yuqian Guo, Xiaolin Huang, Yonghua Xiong, Ben Zhong Tang. (2022) A colorimetric and ratiometric fluorescent paper chip for biogenic amine monitoring based on a simple pH-sensitive AIEgen. CHEMICAL ENGINEERING JOURNAL, 450 (137928). [10.1016/j.cej.2022.137928]
10. Xujing Guo, Xirui Chen, Rui Chen, Yujie Tu, Tianying Lu, Yuqian Guo, Liang Guo, Yonghua Xiong, Xiaolin Huang, Ben Zhong Tang. (2022) Ratiometric Monitoring of Biogenic Amines by a Simple Ammonia-Response Aiegen. Foods, 11 (7): (932). [PMID:35407018] [10.3390/foods11070932]
11. Xu Xu, Jiaxin Gao, Di Cao, Xiang Li, Xin Zhao, Shuang Yue, Lei Zhang. (2022) Designed 3D N-doped magnetic porous carbon spheres for sensitive monitoring of biogenic amine by simultaneous microwave-assisted derivatization and magnetic-solid phase extraction. JOURNAL OF CHROMATOGRAPHY A, 1667 (462882). [PMID:35149412] [10.1016/j.chroma.2022.462882]
12. Yanfang Niu, Sen Li, Junning Zhang, Wang Wan, Zhenzhu He, Jun Liu, Keliang Liu, Sainan Ren, Liqin Ge, Xin Du, Zhongze Gu. (2021) Static–Dynamic Fluorescence Patterns Based on Photodynamic Disulfide Reactions for Versatile Information Storage. Small, 17 (35): (2102224). [PMID:34310021] [10.1002/smll.202102224]
13. Junmei Fan, Enrui Wu, Jinlong Dong, Ruitao Zhu, Meiqin Li, Jiangning Gao, Hongfei Han, Liping Ding. (2021) A minimalist ratiometric fluorescent sensor based on non-covalent ternary platform for sensing H2S in aqueous solution and serum. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 616 (126299). [10.1016/j.colsurfa.2021.126299]
14. Yi-Fang Li, Zheng-Zhong Lin, Cheng-Yi Hong, Zhi-Yong Huang. (2021) Histamine detection in fish samples based on indirect competitive ELISA method using iron-cobalt co-doped carbon dots labeled histamine antibody. FOOD CHEMISTRY, 345 (128812). [PMID:33601655] [10.1016/j.foodchem.2020.128812]
15. Guohui Li, Dixuan Huang, Li Wang, Yu Deng. (2021) Highly efficient whole-cell biosynthesis of putrescine by recombinant Escherichia coli. BIOCHEMICAL ENGINEERING JOURNAL, 166 (107859). [10.1016/j.bej.2020.107859]
16. Xuefei Shao, Baocai Xu, Hui Zhou, Conggui Chen, Peijun Li. (2021) Insight into the mechanism of decreasing N-nitrosodimethylamine by Lactobacillus pentosus R3 in a model system. FOOD CONTROL, 121 (107534). [10.1016/j.foodcont.2020.107534]
17. Chong Ma, Shijuan Zhang, Xia Wu, Jinmao You. (2020) Permanently Positively Charged Stable Isotope Labeling Agents and Its Application in the Accurate Quantitation of Alkylphenols Migrated from Plastics to Edible Oils. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68 (33): (9024–9031). [PMID:32697581] [10.1021/acs.jafc.0c03413]
18. Peng Wang, Sihan Wang, Li Chen, Wenting Wang, Baohui Wang, Yunwen Liao. (2020) A novel peptide-based fluorescent probe for sensitive detection of zinc (II) and its applicability in live cell imaging. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 240 (118549). [PMID:32526399] [10.1016/j.saa.2020.118549]
19. Mengting Ni, Xing Hu, Deming Gong, Guowen Zhang. (2020) Inhibitory mechanism of vitexin on α-glucosidase and its synergy with acarbose. FOOD HYDROCOLLOIDS, 105 (105824). [10.1016/j.foodhyd.2020.105824]
20. Yuxuan Liu, Yunxin Zheng, Hao Wu, Wei Zhang, Tianyu Ren, Shengping You, Wei Qi, Rongxin Su, Zhimin He. (2020) Development of an integrated process for the production of high-purity cadaverine from lysine decarboxylase. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 95 (5): (1542-1549). [10.1002/jctb.6348]
21. Hao Qian, Xiaofei Shen, Hailong Huang, Yan Zhang, Mingtao Zhang, Huiqing Wang, Zhongkai Wang. (2020) Helical poly(phenyl isocyanide)s grafted selectively on C-6 of cellulose for improved chiral recognition ability. CARBOHYDRATE POLYMERS, 231 (115737). [PMID:31888853] [10.1016/j.carbpol.2019.115737]
22. Xu Mao, Jian Wang, Qian Wang, Lan Yang, Yilin Li, Hao Lin, Ying Peng, Jiang Zheng. (2019) Nitidine Chloride–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism. DRUG METABOLISM AND DISPOSITION, 47 (8): (919-927). [PMID:31147316] [10.1124/dmd.119.086892]
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34. Lichen Gou, Ling Li, Siqi Wei, Yunfei Tian, Xiandeng Hou, Li Wu. (2024) Sensitive detection of histamine utilizing the SERS platform combined with an azo coupling reaction and a composite hydrophobic layer. TALANTA, 278 (126531). [PMID:39002262] [10.1016/j.talanta.2024.126531]

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