| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D656801-1ml |
1ml |
期货  |
|
| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | DMU2105 |
| 生化机理 | DMU2105 是一种强效的特异性 CYP1B1 抑制剂，对 CYP1B1 和 CYP1A1 的 IC 50 s 分别为 10 nM 和 742 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
DMU2105 is a potent and specific CYP1B1 inhibitor, with IC 50 s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. In Vitro DMU2105 (Compound 7k) shows 74 and 120-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2105 however, the EC 50 goes down to 1 μM indicating that the cells have suffered from toxicity which may have been mediated by CYP1B1 inhibition. Un-transfected cells (HEK293: pcDNA3.1), when treated with cisplatin and DMU2105 (10×IC 50 ) do not show any perceptible decrease of cisplatin EC 50 (8.5 μM ± 0.9). MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:CYP1B1 10 nM (IC 50 ) CYP1A1 742 nM (IC 50 ) |
| Isomeric SMILES | C1=CC=C2C=C(C=CC2=C1)/C=C/C(=O)C3=CN=CC=C3 |
|---|---|
| 分子量 | 259.30 |
| Reaxy-Rn | 35887540 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=35887540&ln= |
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