| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D656097-1ml |
1ml |
期货  |
|
| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | DAA-1106 |
| 生化机理 | DAA1106是外周苯并二氮杂卓受体（PBR）的强效选择性配体，是外周苯并二氮杂卓受体的强效选择性激动剂：DAA1106与苯并二氮杂卓受体（PBR）的结合在广泛的体外实验中明显增加。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 产品介绍 |
DAA1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), as a potent and selective agonist at the peripheral benzodiazepine receptor.Target:PBRin vitro: DAA1106 binding to PBR was significantly increased in widespread areas in MCI subjects when compared to healthy controls.DAA-1106 is a drug which acts as a potent and selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO, but with no affinity at the GABAA receptor.in vivo: DAA-1106 has anxiolytic effects in animal studies. DAA-1106 has a sub-nanomolar binding affinity (Ki) of 0.28nM, and has been used extensively in its 3H or 11C radiolabelled form to map TSPO in the body and brain, which has proved especially helpful in monitoring the progress of neurodegenerative diseases such as Alzheimer's disease. |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | CC(=O)N(CC1=C(C=CC(=C1)OC)OC)C2=C(C=CC(=C2)F)OC3=CC=CC=C3 |
| 关联CAS | 220551-92-8 |
| PubChem CID | 10430788 |
| MeSH Entry Terms | (11C)DAA1106;DAA 1106;DAA-1106;DAA1106;N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-isophenoxyphenyl)acetamide |
| 分子量 | 395.42 |
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