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16,16-二甲基前列腺素 E₂

有货

库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
D476235-1mg
1mg 期货 Stock Image

基本描述

英文别名 PD021128 | BML1-G03 | DTXSID201025748 | SR-01000946434-1 | CHEBI:141046 | HMS1361E07 | LMFA03010065 | AT35121 | 16,16-dimethyl prostaglandin E2 | 16,16-Dimethylrostaglandin E2 | BD177551 | Q27070785 | Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-16,16-dim
规格或纯度 Moligand™, 醋酸甲酯溶液
英文名称 16,16-Dimethylprostaglandin E₂
储存温度 -20°C储存
运输条件 超低温冰袋运输
作用类型 调节剂
产品介绍


Description



Preparation instructions

Agitation or brief ultrasonication may be necessary for restoration of solutions which have been precipitated due to freezing. The methyl acetate can be removed using N2or vacuum. Stock solutions of 1-5 mg/ml in absolute alcohol may be prepared and diluted with isotonic saline.

关联靶点(人)

PTGER2 Tclin 前列腺素 E2 受体 EP2 亚型(Prostaglandin E2 receptor EP2 subtype) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PTGER4 Tclin 前列腺素 E2 受体 EP4 亚型(Prostaglandin E2 receptor EP4 subtype) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PTGER3 Tclin 前列腺素 E2 受体 EP3 亚型(Prostaglandin E2 receptor EP3 subtype) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
VDR Tclin Vitamin D receptor (26531 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点(其它种属)

Cavia porcellus (23802 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Canis familiaris (36305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IIUPAC Name (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3R)-3-hydroxy-4,4-dimethyloct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
INCHI 1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,19-,20-/m1/s1
InChi Key QAOBBBBDJSWHMU-WMBBNPMCSA-N
Smiles CCCCC(C)(C)C(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
Isomeric SMILES CCCCC(C)(C)[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)O
分子量 380.52
Reaxy-Rn 30981592
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30981592&ln=

化学和物理性质

分子量 380.500 g/mol
XLogP3 3.700
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 12
精确质量Exact Mass 380.256 Da
单同位素质量Monoisotopic Mass 380.256 Da
拓扑极表面积Topological Polar Surface Area 94.800 Ų
重原子数Heavy Atom Count 27
形式电荷Formal Charge 0
复杂度Complexity 535.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 4
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 2
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 2
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性(GHS)

象形图 GHS07
信号词 警告
危险声明

H225: 高度易燃的液体和蒸气

H302: 吞食有害

H312: 皮肤接触有害

H319: 引起严重眼睛刺激

H336: 可能引起嗜睡或头晕

预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P270: 使用本产品时,请勿进食、饮水或吸烟。

P271: 仅在室外或通风良好的地方使用。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理(请参阅此标签上的...)。

P330: 漱口

P302+P352: 如皮肤沾染:用水充分清洗。

P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。

P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。

P501: 将内容物/容器处理到。。。

P301+P317: 如果被吞咽:请寻求医疗帮助。

P317: 寻求紧急医疗救助。

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

引用文献

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3. Dianne Little,Rebecca A Dean,Karen M Young,Shaun A McKane,Linda D Martin,Samuel L Jones,Anthony T Blikslager.  (2002-10-22)  PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum..  American journal of physiology. Gastrointestinal and liver physiology,  284  ((1)): (G46-G56).  [PMID:12388204]
4. Kelly M Towndrow,Zhe Jia,Herng-Hsiang Lo,Maria D Person,Terrence J Monks,Serrine S Lau.  (2003-03-19)  11-Deoxy,16,16-dimethyl prostaglandin E2 induces specific proteins in association with its ability to protect against oxidative stress..  Chemical research in toxicology,  16  ((3)): (312-319).  [PMID:12641431]
5. Terrence E Riehl,Rodney D Newberry,Robin G Lorenz,William F Stenson.  (2003-10-04)  TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine..  American journal of physiology. Gastrointestinal and liver physiology,  286  ((1)): (G166-G173).  [PMID:14525729]
6. Genhai Zhu,Ghassan M Saed,Gunter Deppe,Michael P Diamond,Adnan R Munkarah.  (2004-08-07)  Hypoxia up-regulates the effects of prostaglandin E2 on tumor angiogenesis in ovarian cancer cells..  Gynecologic oncology,  94  ((2)): (422-426).  [PMID:15297183]
7. Brian Hoang,Alice Trinh,Lutz Birnbaumer,Robert A Edwards.  (2007-03-03)  Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts..  American journal of physiology. Gastrointestinal and liver physiology,  292  ((6)): (G1511-G1519).  [PMID:17332478]
8. C Prenn,A Heinemann,R Schuligoi,B A Peskar.  (2008-01-24)  CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine..  Pharmacology,  81  ((3)): (236-240).  [PMID:18212515]
9. Marco Failla,Tiziana Genovese,Emanuela Mazzon,Mary Fruciano,Evelina Fagone,Elisa Gili,Annalisa Barera,Cristina La Rosa,Enrico Conte,Nunzio Crimi,Salvatore Cuzzocrea,Carlo Vancheri.  (2008-12-09)  16,16-Dimethyl prostaglandin E2 efficacy on prevention and protection from bleomycin-induced lung injury and fibrosis..  American journal of respiratory cell and molecular biology,  41  ((1)): (50-58).  [PMID:19059888]
10. Jing-Ruey J Yeh,Kathleen M Munson,Kamaleldin E Elagib,Adam N Goldfarb,David A Sweetser,Randall T Peterson.  (2009-01-28)  Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation..  Nature chemical biology,  ((4)): (236-243).  [PMID:19172146]
11. Brigitta M Peskar,Karlheinz Ehrlich,Rufina Schuligoi,Bernhard A Peskar.  (2009-10-10)  Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats..  Pharmacology,  84  ((5)): (294-299).  [PMID:19816089]
12. Kikuko Amagase,Akimu Ochi,Tetsuya Sugihara,Shinichi Kato,Koji Takeuchi.  (2010-07-14)  Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats..  Journal of gastroenterology and hepatology,  25 Suppl 1  (S111-S118).  [PMID:20586851]
13. Kenichi Nonoyama,Kanako Nakagawa,Kikuko Amagase,Koji Takeuchi,Masahiko Nakamura,Susumu Okabe.  (2010-07-14)  New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin..  Journal of gastroenterology and hepatology,  25 Suppl 1  (S15-S22).  [PMID:20586859]
14. Sara S Roscioni,Bart G J Dekkers,Alwin G Prins,Mark H Menzen,Herman Meurs,Martina Schmidt,Harm Maarsingh.  (2010-09-02)  cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A..  British journal of pharmacology,  162  ((1)): (193-209).  [PMID:20804494]
15. Corey Cutler,Pratik Multani,David Robbins,Haesook T Kim,Thuy Le,Jonathan Hoggatt,Louis M Pelus,Caroline Desponts,Yi-Bin Chen,Betsy Rezner,Philippe Armand,John Koreth,Brett Glotzbecker,Vincent T Ho,Edwin Alyea,Marlisa Isom,Grace Kao,Myriam Armant,Leslie Silberstein,Peirong Hu,Robert J Soiffer,David T Scadden,Jerome Ritz,Wolfram Goessling,Trista E North,John Mendlein,Karen Ballen,Leonard I Zon,Joseph H Antin,Daniel D Shoemaker.  (2013-09-03)  Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation..  Blood,  122  ((17)): (3074-3081).  [PMID:23996087]
16. Ivana Kostic,Isabel Fidalgo-Carvalho,Sezin Aday,Helena Vazão,Tiago Carvalheiro,Mário Grãos,António Duarte,Carla Cardoso,Lino Gonçalves,Lina Carvalho,Artur Paiva,Lino Ferreira.  (2015-11-11)  Lysophosphatidic acid enhances survival of human CD34(+) cells in ischemic conditions..  Scientific reports,  (16406-16406).  [PMID:26553339]
17. T Michael Creed,Rajkumar Baldeosingh,Christian L Eberly,Caroline S Schlee,MinJung Kim,Jevon A Cutler,Akhilesh Pandey,Curt I Civin,Nancy G Fossett,Tami J Kingsbury.  (2019-12-07)  The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis..  Development (Cambridge, England),  147  ((1)): [PMID:31806659]
18. P C Konturek,T Brzozowski,A Duda,S Kwiecien,S Löber,A Dembinski,E G Hahn,S J Konturek.  (2001-10-12)  Epidermal growth factor and prostaglandin E(2) accelerate mucosal recovery from stress-induced gastric lesions via inhibition of apoptosis..  Journal of physiology, Paris,  95  ((1-6)): (361-367).  [PMID:11595461]
19. Brigitta M Peskar,Karlheinz Ehrlich,Bernhard A Peskar.  (2002-05-23)  Role of ATP-sensitive potassium channels in prostaglandin-mediated gastroprotection in the rat..  The Journal of pharmacology and experimental therapeutics,  301  ((3)): (969-974).  [PMID:12023526]
20. Nahid Waleh,Hiroki Kajino,Anne Marilise Marrache,David Ginzinger,Christine Roman,Steven R Seidner,Timothy J M Moss,Jean-Claude Fouron,Alejandro Vazquez-Tello,Sylvain Chemtob,Ronald I Clyman.  (2004-10-13)  Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control..  Circulation,  110  ((16)): (2326-2332).  [PMID:15477420]
21. T Brzozowski,A Tarnawski,D Hollander,S Sekhon,W J Krause,H Gergely.  (2005-10-26)  Comparison of prostaglandin and cimetidine in protection of isolated gastric glands against indomethacin injury..  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,  56 Suppl 5  (75-88).  [PMID:16247190]
22. Carlos Ocaña-Morgner,Kurt A Wong,Flavia Lega,Javier Dotor,Francisco Borras-Cuesta,Ana Rodriguez.  (2007-05-03)  Role of TGF-beta and PGE2 in T cell responses during Plasmodium yoelii infection..  European journal of immunology,  37  ((6)): (1562-1574).  [PMID:17474154]
23. Olga T Starodub,Elise S Demitrack,Heidi K Baumgartner,Marshall H Montrose.  (2007-10-26)  Disruption of the Cox-1 gene slows repair of microscopic lesions in the mouse gastric epithelium..  American journal of physiology. Cell physiology,  294  ((1)): (C223-C232).  [PMID:17959725]
24. Koji Takeuchi,Mayu Tanigami,Kikuko Amagase,Akimu Ochi,Sayaka Okuda,Ryo Hatazawa.  (2010-07-14)  Endogenous prostaglandin E2 accelerates healing of indomethacin-induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptors..  Journal of gastroenterology and hepatology,  25 Suppl 1  (S67-S74).  [PMID:20586869]
25. Weiya Ma.  (2010-07-30)  Chronic prostaglandin E2 treatment induces the synthesis of the pain-related peptide substance P and calcitonin gene-related peptide in cultured sensory ganglion explants..  Journal of neurochemistry,  115  ((2)): (363-372).  [PMID:20666934]
26. Agnes Rasmuson,Anna Kock,Ole Martin Fuskevåg,Björn Kruspig,Jaione Simón-Santamaría,Vladimir Gogvadze,John Inge Johnsen,Per Kogner,Baldur Sveinbjörnsson.  (2012-01-26)  Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma..  PloS one,  ((1)): (e29331-e29331).  [PMID:22276108]
27. Khuyen Gia Hoang,Sarah Allison,Michael Murray,Nenad Petrovic.  (2015-07-21)  Prostanoids regulate angiogenesis acting primarily on IP and EP4 receptors..  Microvascular research,  101  (127-134).  [PMID:26188701]
28. Bhargab Kalita,Rajiv Ranjan,Abhinav Singh,M H Yashavarddhan,Sania Bajaj,Manju Lata Gupta.  (2016-12-31)  A Combination of Podophyllotoxin and Rutin Attenuates Radiation Induced Gastrointestinal Injury by Negatively Regulating NF-κB/p53 Signaling in Lethally Irradiated Mice..  PloS one,  11  ((12)): (e0168525-e0168525).  [PMID:28036347]

溶液计算器