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DL-薄荷醇, TRPA1 激活剂;TRPA1 通路抑制剂;TRPM8 激活剂;TRPV3 激活剂

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
D426737-1ml
1ml 现货 Stock Image

基本描述

别名 (±)-薄荷醇
英文别名 AKOS016843634 | DTXCID30805 | HY-75161 | MENTHOL, UNSPECIFIED FORM | DTXSID8029650 | Menthol (USP) | DL-Menthol, analytical standard | Menthol racemate | 5-methyl-2-(propan-2-yl)cyclohexan-1-ol | Fisherman's friend lozenges | MFCD00062979 | BBL009325 | Cy
规格或纯度 Moligand™, 10mM in DMSO
英文名称 DL-Menthol
储存温度 -80℃储存
运输条件 超低温冰袋运输
作用类型 激活剂
作用机制 TRPA1 激活剂;TRPA1 通路抑制剂;TRPM8 激活剂;TRPV3 激活剂
产品介绍

DL-Menthol triggers cold-sensitive TRPM8 receptors in the skin neurons in vitro. The (-)-Menthol form exists naturally in nature, primarily found in fruit extracts or spearmint extracts. This racemic mixture could theoretically be created by the hydrogenation of the monoterpene pulegone.

DL-Menthol triggers cold-sensitive TRPM8 receptors in the skin neurons in vitro. The (-)-Menthol form exists naturally in nature, primarily found in fruit extracts or spearmint extracts. This racemic mixture could theoretically be created by the hydrogenation of the monoterpene pulegone.
A chemical which triggers cold-sensitive TRPM8 receptors in the skin neurons in vitro.

关联靶点(人)

TRPM8 Tclin 瞬时受体电位阳离子通道亚家族M成员8(Transient receptor potential cation channel subfamily M member 8) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
VDR Tclin Vitamin D receptor (26531 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HEK293 (82097 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT2B7 Tchem UDP-glucuronosyltransferase 2B7 (787 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT2B15 Tbio UDP-glucuronosyltransferase 2B15 (172 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (448 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A6 Tbio UDP-glucuronosyltransferase 1-6 (221 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A8 Tbio UDP-glucuronosyltransferase 1-8 (233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A9 Tbio UDP-glucuronosyltransferase 1-9 (343 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A3 Tbio UDP-glucuronosyltransferase 1-3 (217 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点(其它种属)

Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cutibacterium acnes (887 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Spodoptera littoralis (798 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cavia porcellus (23802 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Musca domestica (713 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Tetranychus urticae (2600 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rdl GABA receptor subunit (76 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trpm8 Transient receptor potential cation channel subfamily M member 8 (889 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Colletotrichum gloeosporioides (560 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Culex pipiens (191 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Leptinotarsa decemlineata (1161 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Psoroptes ovis (78 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Lipaphis erysimi (85 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Theba pisana (23 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 201-939-0
分子类型 小分子
IIUPAC Name 5-methyl-2-propan-2-ylcyclohexan-1-ol
INCHI 1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3
InChi Key NOOLISFMXDJSKH-UHFFFAOYSA-N
Smiles CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Isomeric SMILES CC1CCC(C(C1)O)C(C)C
关联CAS 15356-70-4;1490-04-6
分子量 156.27
Beilstein号 3194263
Reaxy-Rn 1902293
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1902293&ln=

化学和物理性质

闪点(℉) 199.4 °F
闪点(℃) 93 °C
沸点 216°C
熔点 32-36°C
分子量 156.260 g/mol
XLogP3 3.000
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 1
可旋转键计数Rotatable Bond Count 1
精确质量Exact Mass 156.151 Da
单同位素质量Monoisotopic Mass 156.151 Da
拓扑极表面积Topological Polar Surface Area 20.200 Ų
重原子数Heavy Atom Count 11
形式电荷Formal Charge 0
复杂度Complexity 120.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 3
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性(GHS)

象形图 GHS07
信号词 警告
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

预防措施声明

P264: 处理后要彻底洗手。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理(请参阅此标签上的...)。

P302+P352: 如皮肤沾染:用水充分清洗。

P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。

P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续:寻求医疗帮助。

P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。

WGK Germany 2
RTECS OT0350000
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

此产品的引用文献

引用文献

1. Zhou Qian, Su XiaoLu, Yao YanXing, He Bin, Jin FengMei, Gao MengYue, Wang Qi, Feng GuiPing, Li BaoXi, Liu Rui, Dong Jun.  (2023)  Preparation of a hydrophobic deep eutectic solvent and its application in the detection of quinolone residues in cattle urine.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  415  (17): (3581-3592).  [PMID:37243734] [10.1007/s00216-023-04749-w]
2. Jingyu Zhang, Zhihui Zhang, Liping Yao, Mingrong Qian, Zuguang Li, Yulin Han, Shanshan Bai, Mawrong Lee.  (2023)  pH-responsive switchable deep eutectic solvents to mediate pretreatment method for trace analysis of triazole fungicides in peel wastes.  FOOD CHEMISTRY,  411  (135486).  [PMID:36682163] [10.1016/j.foodchem.2023.135486]
3. Meichao Liao, Lin Yang, Xiaoyue Yang, Erxu Wang, Bin Lu, Jiye Wang, Li Duan.  (2023)  Vortex-assisted liquid–liquid microextraction based on hydrophobic deep eutectic solvent for the urinary excretion study of Taraxacum mongolicum extract in rats.  MICROCHEMICAL JOURNAL,  184  (108167).  [10.1016/j.microc.2022.108167]
4. Wen-wen Deng, Xue-ping Mei, Zi-jun Cheng, Tian-xiang gan, Xuan Tian, Jiang-nan Hu, Chuan-ru Zang, Bo Sun, Jing Wu, Yin Deng, Reza. A. Ghiladi, George H. Lorimer, Gizem Keceli, Jun Wang.  (2023)  Extraction of weak hydrophobic sulforaphane from broccoli by salting-out assisted hydrophobic deep eutectic solvent extraction.  FOOD CHEMISTRY,  405  (134817).  [PMID:36370577] [10.1016/j.foodchem.2022.134817]
5. Heng Lu, Xiaohong Tan, Guobin Huang, Shaoru Wu, Yanmei Zhou, Junying Zhang, Qiaowen Zheng, Tianju Chen, Feiming Li, Zhixiong Cai, Jingbin Zeng, Maosheng Zhang.  (2022)  Green synthesis of highly stable CsPbBr3 perovskite nanocrystals using natural deep eutectic solvents as solvents and surface ligands.  Nanoscale,  14  (46): (17222-17229).  [PMID:36250272] [10.1039/D2NR04173A]
6. Jiaze Yan, Shaomin Ma, Mingrui Feng, Jiqi Zheng, Ming Guo.  (2022)  Hydrophobic deep eutectic solvent-based ultrasonic-assisted liquid-liquid microextraction combined with GC for eugenol, isoeugenol, and methyl isoeugenol determination in aquatic products.  Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment,  [PMID:35997563] [10.1080/19440049.2022.2112764]
7. Meichao Liao, Yang Zhao, Xiaoyue Yang, Lin Yang, E-Hu Liu, Bin Lu, Jiye Wang, Xiaopeng Liu, Yanzhong Chang, Li Duan.  (2022)  A greener and sustainable route for medicinal plant analysis: Recycle utilization of hydrophobic deep eutectic solvent.  MICROCHEMICAL JOURNAL,  178  (107372).  [10.1016/j.microc.2022.107372]
8. Tian Quan, Dandan Wang, Lijuan Yang, Shaochi Liu, Yongqin Tao, Junji Wang, Linlin Deng, Xun Kang, Kailian Zhang, Zhining Xia, Die Gao.  (2022)  Effective extraction methods based on hydrophobic deep eutectic solvent coupled with functional molecularly imprinted polymers: Application on quercetagetin extraction from natural medicine and blood.  MICROCHEMICAL JOURNAL,  174  (107076).  [10.1016/j.microc.2021.107076]
9. Jing Li, Yanjun Jiao, Qin Luo, Weixin Hu, Shenwen Fang, Chunling Tang, Qiang Liu.  (2021)  Treatment of oil-based drill cuttings by hydrophobic deep eutectic solvents.  CANADIAN JOURNAL OF CHEMICAL ENGINEERING,  100  (8): (1747-1754).  [10.1002/cjce.24263]
10. Tong Wang, Qing Wang, Qing Guo, Ping Li, Hua Yang.  (2021)  A hydrophobic deep eutectic solvents-based integrated method for efficient and green extraction and recovery of natural products from Rosmarinus officinalis leaves, Ginkgo biloba leaves and Salvia miltiorrhiza roots.  FOOD CHEMISTRY,  363  (130282).  [PMID:34144425] [10.1016/j.foodchem.2021.130282]
11. Ge Dandan, Wang Ying, Jiang Qian, Dai Enrui.  (2019)  A Deep Eutectic Solvent as an Extraction Solvent to Separate and Preconcentrate Parabens in Water Samples Using in situ Liquid-Liquid Microextraction.  JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY,  30  (6): (1203-1210).  [10.21577/0103-5053.20190014]
12. Dandan Ge, Yi Zhang, Yixiu Dai, Shumin Yang.  (2018)  Air-assisted dispersive liquid–liquid microextraction based on a new hydrophobic deep eutectic solvent for the preconcentration of benzophenone-type UV filters from aqueous samples.  JOURNAL OF SEPARATION SCIENCE,  41  (7): (1635-1643).  [PMID:29282887] [10.1002/jssc.201701282]
13. Linzhou Zhuang, Beibei Ma, Siyu Chen, Xunan Hou, Shuixia Chen.  (2015)  Fast synthesis of mesoporous silica materials via simple organic compounds templated sol–gel route in the absence of hydrogen bond.  MICROPOROUS AND MESOPOROUS MATERIALS,  213  (22).  [10.1016/j.micromeso.2015.04.007]
14. Jiaze Yan, Chao Jiang, Jiqi Zheng, Ming Guo.  (2025)  Enhanced microdialysis based on hydrophobic deep eutectic solvents for sampling of eugenol in Glyptocidaris crenularis.  ANALYTICA CHIMICA ACTA,  1346  (343774).  [PMID:40021328] [10.1016/j.aca.2025.343774]

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