| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D424780-1ml |
1ml |
现货  |
|
| 别名 | DOC acetate | 乙酸去氧皮质酮 | Doca |
|---|---|
| 英文别名 | Deoxycorticosterone acetate | 56-47-3 | DESOXYCORTICOSTERONE ACETATE | DOCA | Desoxycortone acetate | Cortexone acetate | Percotol | DOC acetate | Decosteron | Decosterone | Sincortex | 11-Deoxycorticosterone acetate | Decostrate | Descorterone | Docaquosum | Dorcostrin | Krinocorts | Pri |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Deoxycorticosterone acetate |
| 生化机理 | 类固醇激素通常用于诱发实验动物的高血压。这种形式的高血压取决于对包括大脑肾素-血管紧张素系统在内的中枢升压机制的调节。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | 矿质皮质激素受体激动剂 |
| 产品介绍 |
Deoxycorticosterone acetate是一种类固醇激素，用于肌肉注射，是肾上腺皮质类固醇的代替疗法。 Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid. |
| ALogP | 3.1 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 200-275-9 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | [2-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate |
| INCHI | 1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1 |
| InChi Key | VPGRYOFKCNULNK-ACXQXYJUSA-N |
| Smiles | CC(=O)OCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C |
| Isomeric SMILES | CC(=O)OCC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C |
| 分子量 | 372.5 |
| Beilstein号 | 2570798 |
| Reaxy-Rn | 1894700 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1894700&ln= |
| 比旋光度 | 20/D： +170.0 to +180.0 deg(C=1, Dioxane) |
|---|---|
| 熔点 | 157°C |
| 分子量 | 372.500 g/mol |
| XLogP3 | 3.100 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 372.23 Da |
| 单同位素质量Monoisotopic Mass | 372.23 Da |
| 拓扑极表面积Topological Polar Surface Area | 60.400 Ų |
| 重原子数Heavy Atom Count | 27 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 707.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 6 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS08 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H360: 可能损害生育力或未出生的孩子 H373: 通过长时间或反复暴露对器官造成损害 |
| 预防措施声明 |
P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。 P403+P235: 存放在通风良好的地方。保持低温。 P501: 将内容物/容器处理到。。。 |
| WGK Germany | 3 |
| RTECS | HG0525000 |
| 个人防护装备 | Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter |
| 1. Hao Jiameng, Chang Liping, Wang Dandong, Ji Chuanyuan, Zhang Shaolan, Hou Yunlong, Wu Yiling. (2023) Periplocin Alleviates Cardiac Remodeling in DOCA-Salt–Induced Heart Failure Rats. Journal of Cardiovascular Translational Research, 16 (1): (127-140). [PMID:35616880] [10.1007/s12265-022-10277-2] |
| 2. Yanhong Liu, Lingchao Li, Jiyong Liu, Mengnan Yang, Honglan Wang, Xuxin Chu, Jianping Zhou, Meirong Huo, Tingjie Yin. (2021) Biomineralization-inspired dasatinib nanodrug with sequential infiltration for effective solid tumor treatment. BIOMATERIALS, 267 (120481). [PMID:33189053] [10.1016/j.biomaterials.2020.120481] |
| 3. Yuanyuan Xu, Younan Ren, Jie Zhang, Bo Niu, Mengru Liu, Tifei Xu, Xian Zhang, Jianhua Shen, Kai Wang, Zhengyu Cao. (2024) Discovery of pyridazinone derivatives bearing tetrahydroimidazo[1,2-a]pyrazine scaffold as potent inhibitors of transient receptor potential canonical 5 to ameliorate hypertension-induced renal injury in rats. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 275 (116565). [PMID:38878518] [10.1016/j.ejmech.2024.116565] |
| 4. Tingting Zhou, Zhiwei Wang, Xiaowang Lv, Mengting Guo, Ning Zhang, Liangju Liu, Li Geng, Jing Shao, Ka Zhang, Mengru Gao, Aiqin Mao, Yifei Zhu, Fan Yu, Lei Feng, Xiaoyan Wang, Qixiao Zhai, Wei Chen, Xin Ma. (2025) Targeting gut S. aureofaciens Tü117 serves as a new potential therapeutic intervention for the prevention and treatment of hypertension. Cell Metabolism, 37 (496-513.e11). [PMID:39908987] [10.1016/j.cmet.2025.01.004] |
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