| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D423225-1ml |
1ml |
现货  |
|
| 别名 | (R)-2-氨基-3-羟基丙酸, β-羟基丙氨酸 | D-2-氨基-3-羟基丙酸 | D-β-羟基丙氨酸 |
|---|---|
| 英文别名 | D-Ser | (R)-Serine | D-(+)-Serine;d-serine;D-2-Amino-3-hydroxypropionic acid; (R)-2-Amino-3-hydroxypropionic acid | N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide | A20674 | C00740 | s6224 | NCGC00094363-10 | NCGC00094363-07 | NCGC00261773-01 | |
| 规格或纯度 | Moligand™, 10mM in Water |
| 英文名称 | D-Serine |
| 生化机理 | NMDA甘氨酸结合位点和激动突触后甘氨酸受体的激动剂。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | GluN1 的激动剂;GluN2A 的激动剂;GluN2B 的激动剂;GluN2C 的激动剂;GluN2D 的激动剂 |
| 产品介绍 |
D -丝氨酸已被用作人 1321N1 星形细胞瘤细胞中 D -氨基酸氧化酶 (DAO) 活性的底物。它还被用于大鼠脑室内给药以诱导抗伤害刺激效应。 D-丝氨酸已被用于防止 N-甲基 D-天冬氨酸受体 (NMDAR) 的甘氨酸依赖性脱敏，并研究了其对 NMDARs 的作用，以纠正部分坐骨神经结扎 (PSNL) 后大鼠的行为异常 D-丝氨酸是一种在哺乳动物大脑中表达的特殊氨基酸。D -丝氨酸是一种右旋氨基酸，存在于神经元、星形胶质细胞和小胶质细胞中。由丝氨酸消旋酶从 L -丝氨酸合成。消旋酶也可催化 D -丝氨酸分解成氨和丙酮酸。它可被 D -氨基酸氧化酶氧化为羟基丙酮酸。 D-serine has been used as a substrate in D-amino acid oxidase (DAO) activity in human 1321N1 astrocytoma cells. It has also been used in intracerebroventricular administration in rat for the induction of antinociceptive effect. D-serine has been used to prevent glycine-dependent desensitization of N-methyl D-aspartate receptor (NMDAR) and to study its effects on NMDARs to correct behavioral abnormalities in rats after partial sciatic nerve ligation (PSNL) product description： D-serine is an unusual amino acid expressed in the mammalian brain.D-serine is a dextro amino acid present in neurons, astrocytes, and microglia. It is synthesized from L-serine by the enzyme serine racemase. Racemase also catalyzes the breakdown of D-serine into ammonia and pyruvate. It is oxidized to hydroxypyruvate by D-amino acid oxidase. application： D-Serine is involved in the biosynthesis of purines, pyrimidines, and other amino acids. D-Serine also is an agonist of glycine site of the NMDA-type glutamate receptor. It also acts as Lacosamide intermediate. |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 206-229-4 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (2R)-2-amino-3-hydroxypropanoic acid |
| INCHI | 1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1 |
| InChi Key | MTCFGRXMJLQNBG-UWTATZPHSA-N |
| Smiles | C(C(C(=O)O)N)O |
| Isomeric SMILES | C([C@H](C(=O)O)N)O |
| 分子量 | 105.09 |
| Beilstein号 | 1721403 |
| Reaxy-Rn | 1721402 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1721402&ln= |
| 比旋光度 | -15 ° (C=10, HCl(1+5)) |
|---|---|
| 熔点 | 220°C |
| 分子量 | 105.090 g/mol |
| XLogP3 | -3.100 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 105.043 Da |
| 单同位素质量Monoisotopic Mass | 105.043 Da |
| 拓扑极表面积Topological Polar Surface Area | 83.600 Ų |
| 重原子数Heavy Atom Count | 7 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 72.600 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
| 1. Yiyi Liu, Fangling Wu, Jiabin Wang, Ling Pu, Chuan-Fan Ding. (2022) Simultaneous chirality separation of amino acids and their derivative by natamycin based on mobility measurements. ANALYTICA CHIMICA ACTA, 1227 (340298). [PMID:36089312] [10.1016/j.aca.2022.340298] |
| 2. Chengyi Xie, Liancheng Gu, Qidi Wu, Lei Li, Chenlu Wang, Jiancheng Yu, Keqi Tang. (2021) Effective Chiral Discrimination of Amino Acids through Oligosaccharide Incorporation by Trapped Ion Mobility Spectrometry. ANALYTICAL CHEMISTRY, 93 (2): (859–867). [PMID:33226780] [10.1021/acs.analchem.0c03461] |
| 3. Yanni Miao, Qi Liu, Wei Wang, Li Liu, Li Wang. (2017) Enantioseparation of amino acids by micellar capillary electrophoresis using binary chiral selectors and determination of D-glutamic acid and D-aspartic acid in rice wine. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, [10.1080/10826076.2017.1364263] |
| 4. Zhang E, Bai PY, Cui DY, Chu WC, Hua YG, Liu Q, Yin HY, Zhang YJ, Qin S, Liu HM.. (2018) Synthesis and bioactivities study of new antibacterial peptide mimics: The dialkyl cationic amphiphiles.. Eur J Med Chem, 143 (1489-1509). [PMID:29126736] [10.1016/j.ejmech.2017.10.044] |
| 5. Fangqin Wang, Wenrong Cai, Lilan Tan, Junyao Li, Datong Wu, Yong Kong. (2024) A Liquid–Liquid Interfacial Strategy for Construction of Electroactive Chiral Covalent–Organic Frameworks with the Aim to Enlarge the Testing Scope of Chiral Electroanalysis. ANALYTICAL CHEMISTRY, 96 (7): (3200-3207). [PMID:38335728] [10.1021/acs.analchem.3c05744] |
| 6. Dongbo Wang, Jingting Sang, Mingyang Wang, Dawei Luo, Dandan Han, Bowen Zhang, Jingtao Wang, Junbo Gong. (2025) Direct crystallization resolution of chiral compounds assisted by chiral ionic liquids through conformational matching. SEPARATION AND PURIFICATION TECHNOLOGY, 360 (130912). [10.1016/j.seppur.2024.130912] |
| 7. Chen Chao, Ma Yinglin, Yao Kunda, Ji Qingmin, Liu Wei. (2024) Enantioselective adsorption on chiral ceramics with medium entropy. Nature Communications, 15 (1): (1-11). [PMID:39572550] [10.1038/s41467-024-54414-8] |
| 8. Wenchan Deng, Chundan Ye, Wei Wang, Rongrong Huang, Cheng Guo, Yuanjiang Pan, Cuirong Sun. (2024) LC-MS analysis of chiral amino acids in human urine reveals D-amino acids as potential biomarkers for colorectal cancer. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1245 (124270). [PMID:39121519] [10.1016/j.jchromb.2024.124270] |
| 9. Lilan Tan, Wenrong Cai, Fangqin Wang, Junyao Li, Datong Wu, Yong Kong. (2024) Postsynthetic Modification Strategy for Constructing Electrochemiluminescence-Active Chiral Covalent Organic Frameworks Performing Efficient Enantioselective Sensing. ANALYTICAL CHEMISTRY, 96 (9): (3942-3950). [PMID:38394220] [10.1021/acs.analchem.3c05887] |
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