| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D421240-1ml |
1ml |
现货  |
|
| 别名 | (2,3-二油氧基丙基)三甲基氯化铵 | DOTAP 氯化物 | N- [1-(2,3-二油酰氧基)丙基] -N,N,N-三甲基氯化铵 | 1,2-二油酰基-3-三甲基铵-丙烷(氯盐) |
|---|---|
| 英文别名 | J-006134 | Nihonthrene Fast Orange R | HY-112754A | N-(2,3-Dioleoyloxy)propyl-N,N,N-trimethylammonium Chloride | 3R78UC794Z | SCHEMBL120377 | 1,2-Dioleoyl-3-trimethylammonium-propane,Chloride | 18:1 TAP (DOTAP), 1,2-dioleoyl-3-trimethylammonium-propane (c |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) |
| 生化机理 | DOTAP氯化物可用于制备脂质体，且无需使用助磷脂。DOTAP氯化物可溶于二甲基亚砜(DMSO)和乙醇，借此可明确其作为转染试剂的作用。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
用途： DOTAP氯化物已用于制备阳性脂质体和脂质体-DNA复合体。它还用于评估肿瘤坏死因子α (TNF- α)的产生。由阳离子脂质体组成的化合物，用于向真核细胞中转染DNA、RNA及其他负电性分子。DNA与DOTAP混合时会自动形成稳定的复合物，后者可直接加入细胞培养基中。这些复合物能够与细胞膜融合并向细胞质中释放DNA。细胞被高效转染的同时不会产生细胞毒性。每μg DNA需使用5-10 μg左右的DOTAP，每mL 细胞培养基需加入约10-20 μg DOTAP。最佳的工作浓度和转染试剂视被转染的细胞系，以及转染试材类型（RNA、DNA、蛋白）而定。 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride |
| INCHI | 1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-; |
| InChi Key | KSXTUUUQYQYKCR-LQDDAWAPSA-M |
| Smiles | CCCCCCCCC=CCCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC.[Cl-] |
| Isomeric SMILES | CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC.[Cl-] |
| 分子量 | 698.54 |
| Reaxy-Rn | 22197383 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22197383&ln= |
| 分子量 | 698.500 g/mol |
|---|---|
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 37 |
| 精确质量Exact Mass | 697.578 Da |
| 单同位素质量Monoisotopic Mass | 697.578 Da |
| 拓扑极表面积Topological Polar Surface Area | 52.600 Ų |
| 重原子数Heavy Atom Count | 48 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 754.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 2 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 2 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
| 1. Yandong Xie, Xueying Lu, Zhen Wang, Mingxi Liu, Liang Liu, Ran Wang, Kun Yang, Hong Xiao, Jianyong Li, Xianglong Tang, Hongyi Liu. (2022) A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma. Biomaterials Science, 10 (23): (6791-6803). [PMID:36314541] [10.1039/D2BM01145J] |
| 2. Si Huang, Yong-Jiang Li, Jun-Yong Wu, Xin-Yan Hao, Wen-Jie Xu, Yu-Chen Tang, Min Zhou, Jichun Zhang, Shilin Luo, Da-Xiong Xiang. (2024) Biomimetic nanodecoys deliver cholesterol-modified heteroduplex oligonucleotide to target dopaminergic neurons for the treatment of Parkinson's disease. Acta Biomaterialia, [PMID:38244661] [10.1016/j.actbio.2024.01.019] |
| 3. Zhiqiang Zhang, Qinglong Wang, Haibo Zhang, Shengchao Wang, Xia Ma, Hui Wang. (2024) Golm1 facilitates the CaO2-DOPC-DSPE200-PEI -CsPbBr3 QDs -induced apoptotic death of hepatocytes through the stimulation of mitochondrial autophagy and mitochondrial reactive oxygen species production through interactions with P53/Beclin-1/Bcl-2. CHEMICO-BIOLOGICAL INTERACTIONS, 398 (111076). [PMID:38815669] [10.1016/j.cbi.2024.111076] |
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