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蛇形菌素标准溶液
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库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D137911-2ml |
2ml |
现货  |
|
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基本描述
| 英文别名 | Diacetoxyscirpenol | 2270-40-8 | Anguidin | Anguidine | 4,15-Di-O-acetylscirpenol | 4,15-Diacetoxyscirpen-3-ol | MLS000863617 | UYL28I099N | 4,15-Diacetoxyscirp-9-en-3-ol | SMR000440757 | 4,15-Diacetoxyscirpenol | NSC 141537 | NSC-141537 | Scirpenetriol 4,15-diacetate | MM 4462 | Scir |
|---|---|
| 规格或纯度 | 分析标准品, 100 μg/mL in acetonitrile |
| 英文名称 | Diacetoxyscirpenol |
| 储存温度 | -20°C储存,充氩 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Diacetoxyscirpenol is a mycotoxin belonging to 12,13-epoxytrichothecene group, produced by several Fusarium strains together with some other toxins such as T2 and HT2 toxins. Causes fusarium toxicosis in farm animals.Diacetoxyscirpenol (Anguidine) and its derivates possess anticancer properties. Diacetoxyscirpenol (Anguidine) inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells. Diacetoxyscirpenol (Anguidine) also has been shown to both potentiate and protect against the cytotoxic effects of other drμgs. There were 14 clinical trials reported, all in the area of colorectal tumors and leukemia. No records found after 1985. Apoptosis inducement. Diacetoxyscirpenol is a mycotoxin belonging to 12,13-epoxytrichothecene group, produced by several Fusarium strains together with some other toxins such as T2 and HT2 toxins. Causes fusarium toxicosis in farm animals. |
关联靶点（人）
XBP1
Tchem
X-box结合蛋白1(X-box-binding protein 1)
(1 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
TP53
Tchem
Cellular tumor antigen p53
(48468 活性数据)
A498
(42825 活性数据)
CCRF-CEM
(65223 活性数据)
COLO 205
(50209 活性数据)
HL-60
(67320 活性数据)
K562
(73714 活性数据)
M14
(47487 活性数据)
MCF7
(126967 活性数据)
MOLT-4
(49676 活性数据)
RXF 393
(41971 活性数据)
SK-MEL-2
(46422 活性数据)
UACC-62
(47335 活性数据)
786-0
(47912 活性数据)
A549
(127892 活性数据)
NCI-H125
(67 活性数据)
HCT-116
(91556 活性数据)
Jurkat
(10389 活性数据)
MDA-MB-435
(38290 活性数据)
MDA-N
(28205 活性数据)
NCI-H226
(44470 活性数据)
NCI-H522
(44358 活性数据)
HCT-15
(51914 活性数据)
HTT
Tchem
Huntingtin
(19182 活性数据)
EHMT2
Tchem
Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
(93046 活性数据)
SNCA
Tchem
Alpha-synuclein
(10960 活性数据)
TDP1
Tchem
Tyrosyl-DNA phosphodiesterase 1
(345557 活性数据)
SMAD3
Tchem
Mothers against decapentaplegic homolog 3
(68039 活性数据)
NPC1
Tchem
Niemann-Pick C1 protein
(18985 活性数据)
GMNN
Tbio
Geminin
(128009 活性数据)
RAB9A
Tbio
Ras-related protein Rab-9A
(22488 活性数据)
microRNA 21
(64692 活性数据)
XBP1
Tchem
X-box-binding protein 1
(1001 活性数据)
ATAD5
Tbio
ATPase family AAA domain-containing protein 5
(122566 活性数据)
IDH1
Tclin
Isocitrate dehydrogenase [NADP] cytoplasmic
(40980 活性数据)
关联靶点（其它种属）
Saccharomyces cerevisiae (19171 活性数据)
Plasmodium falciparum (966862 活性数据)
Mus musculus (284745 活性数据)
L1210 (27553 活性数据)
L5178Y (1809 活性数据)
MC-38 (857 活性数据)
BCHE
Cholinesterase (8742 活性数据)
Giardia (1682 活性数据)
Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 活性数据)
Rorc
Nuclear receptor ROR-gamma (89407 活性数据)
NS1
Nonstructural protein 1 (33327 活性数据)
TIM10
Mitochondrial import inner membrane translocase subunit TIM10 (1435 活性数据)
Ddit3
DNA damage-inducible transcript 3 protein (953 活性数据)
vpr
Aberrant vpr protein (14595 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| EC号 | 200-835-2 |
|---|---|
| 分子类型 | 小分子 |
| Isomeric SMILES | CC1=C[C@@H]2[C@](CC1)([C@]3([C@@H]([C@H]([C@H]([C@@]34CO4)O2)O)OC(=O)C)C)COC(=O)C |
| 分子量 | 366.41 |
| Reaxy-Rn | 38538014 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=38538014&ln= |
化学和物理性质
| 闪点(℉) | 5°C |
|---|---|
| 闪点(℃) | 5°C |
| 熔点 | 160°C- 164°C |
| 分子量 | 366.400 g/mol |
| XLogP3 | 0.200 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 366.168 Da |
| 单同位素质量Monoisotopic Mass | 366.168 Da |
| 拓扑极表面积Topological Polar Surface Area | 94.600 Ų |
| 重原子数Heavy Atom Count | 26 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 687.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 7 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS02, GHS07 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H225: 高度易燃的液体和蒸气 H319: 引起严重眼睛刺激 H302+H312+H332: 吞咽，皮肤接触或吸入有害。 |
| 预防措施声明 |
P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。 P233: 保持容器密闭。 P240: 地面/粘结容器和接收设备 P241: 使用防爆的[电气/通风/照明/.../]设备。 P242: 仅使用无火花的工具。 P243: 采取防静电措施 P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P330: 漱口 P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。 P303+P361+P353: 如皮肤（或头发）沾染：立即脱掉所有沾染的衣服。用水清洗皮肤/淋浴。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P337+P313: 如仍觉眼刺激：求医/就诊。 P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。 P403+P235: 存放在通风良好的地方。保持低温。 P501: 将内容物/容器处理到。。。 P304+P340+P312: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。如感觉不适，呼叫急救中心/医生。 |
| WGK Germany | 2 |
| 个人防护装备 | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 L2122120 |
分析证书 | D137911 |
此产品的引用文献
引用文献
| 1. Mingming Chen, Bihang Su, Huiying Wu, Yawen Dai, Tianwen Chen, Fengfu Fu, Zhenyu Lin, Yongqiang Dong. (2024) Hydrogel SERS chip with strong localized surface plasmon resonance for sensitive and rapid detection of T-2 toxin. TALANTA, 268 (125329). [PMID:37879204] [10.1016/j.talanta.2023.125329] |
| 2. Jiana Lin, Gongke Li, Yuling Hu, Qisheng Zhong. (2025) Host-guest mediated recognition and rapid extraction of Fusarium mycotoxins in cereals by nickel ferrite magnetic calix[4]arene-derived covalent organic framework fabricated in room-temperature. FOOD CHEMISTRY, 464 (141887). [PMID:39522376] [10.1016/j.foodchem.2024.141887] |