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1,2-二棕榈酰-sn-甘油-3-磷酰胆碱（DPPC）

含有棕榈酰基-酰基的磷脂酰胆碱
42篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
D130424-100mg
 100mg 现货 Stock Image
D130424-500mg
 500mg 现货 Stock Image
D130424-1g
 1g 现货 Stock Image
D130424-5g
 5g 现货 Stock Image
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Liposome (117) Metabolic Enzyme/Protease (4889) 代谢物 (8911) 元素分类的化合物 (2083) 合成磷脂 (19) 磷化合物 (461) 磷脂 (112) 磷脂酰胆碱 (5) 脂质代谢 (4331)
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基本描述

别名 1,2-双十六烷酰基-sn-丙三醇-3-磷酸胆碱 | 磷酸2,3-双(棕榈酰氧基)丙基[2-(三甲铵)乙酯] | 1,2-双十六酰基-sn-甘油-3-磷酰胆碱 | 1,2-二棕榈酰- L -卵磷脂 | L-β,γ-二棕榈酰-α-卵磷脂 | PC, (7R)-4-羟基-N,N,N-三甲基-10-氧代-7-[(1-氧代十六烷基)氧基]- 3,5,9-三氧杂-4-磷杂二十五烷-1-铵4-氧化物 | 内盐,1,2-二十六酰- 锡 -甘油基-3-磷酸胆碱 | 1,2-二棕榈酰-sn-甘油-3-磷酰胆碱 | L-α-
英文别名 PC, (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]- 3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide | inner salt, 1,2-Dihexadecanoyl-sn-glycero-3-phosphocholine | DPPC, PC(16:0/16:0)
规格或纯度 Moligand™, ≥99%
英文名称 1,2-dipalmitoyl-sn-glycero-3-phosphocholine（DPPC）
生化机理 1,2-双十六酰基-sn-甘油-3-磷酰胆碱(DPPC)是一种表面活性剂，可降低表面张力。它可联用1,2-二油酰-sn-甘油-3磷酰胆碱(DOPC)制备脂质双分子层。DPPC可单独或联用其他磷脂进行有效的药物包埋和递送。
储存温度 -20°C储存,充氩
运输条件 超低温冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

1,2-双十六酰基-sn-甘油-3-磷酰胆碱(DPPC)由不饱和磷脂酰胆碱(PC)通过直接的从头合成经由α1,2-二棕榈酰甘油二酯中间体而合成。磷酸胆碱转移酶酶催化1,2-二棕榈酰甘油二酯向DPPC转化。DPPC也能在重塑途径中通过不饱和PC的脱乙酰化而合成。

应用：
16:0 PC (DPPC)已用于制备、(TQ)脂质体、金纳米棒和氯化钙包埋脂质体以及用于生物物理研究的双分子层。
纯度 ≥99%

产品属性

ALogP 13.5

关联靶点（人）

F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

ampC Beta-lactamase AmpC (62480 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 200-567-6
分子类型 小分子
IIUPAC Name [(2R)-2,3-di(hexadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
INCHI 1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1
InChi Key KILNVBDSWZSGLL-KXQOOQHDSA-N
Smiles CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC
Isomeric SMILES CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC
分子量 734.039
Beilstein号 4(4)1463
Reaxy-Rn 1917965
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1917965&ln=

化学和物理性质

溶解性 Chloroform (Slightly), Methanol (Slightly)
敏感性 对湿度敏感:对热敏感
比旋光度 +5.0 to +8.0 deg(C=2, CHCl3)
熔点 220°C(lit.)
分子量 734.000 g/mol
XLogP3 13.500
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 8
可旋转键计数Rotatable Bond Count 40
精确质量Exact Mass 733.562 Da
单同位素质量Monoisotopic Mass 733.562 Da
拓扑极表面积Topological Polar Surface Area 111.000 Ų
重原子数Heavy Atom Count 50
形式电荷Formal Charge 0
复杂度Complexity 826.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 1
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 3
Merck Index 2477

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批号(Lot Number) 证书类型 货号
I2510425 分析证书 D130424
I2510426 分析证书 D130424
I2510433 分析证书 D130424
I2510434 分析证书 D130424
D2323434 分析证书 D130424
D2323436 分析证书 D130424
C2525550 分析证书 D130424
C2525551 分析证书 D130424
C2525552 分析证书 D130424
D2323437 分析证书 D130424
K2420416 分析证书 D130424
K2420420 分析证书 D130424
K2420429 分析证书 D130424
K2420430 分析证书 D130424
I2423160 分析证书 D130424
I2423161 分析证书 D130424
I2423162 分析证书 D130424
D2402435 分析证书 D130424
D2402193 分析证书 D130424
D2402436 分析证书 D130424
C2226263 分析证书 D130424
C2226264 分析证书 D130424
I2101248 分析证书 D130424
G2220537 分析证书 D130424
G2220538 分析证书 D130424
G2220539 分析证书 D130424
C2226261 分析证书 D130424
C2226514 分析证书 D130424

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  1. 1,2-二棕榈酰-sn-甘油-3-磷酰胆碱
    1,2-二棕榈酰-sn-甘油-3-磷酰胆碱

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引用文献

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