| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D126565-10mg |
10mg |
现货  |
| |
| D126565-50mg |
50mg |
现货 |
|
| 别名 | 决奈达隆 |
|---|---|
| 英文别名 | Multaq | A807786 | HY-A0016 | NCGC00188863-02 | Tox21_113008 | DTXSID3048653 | N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)methanesulfonamide | UNII-JQZ1L091Y2 | DRONEDARONE BASE | L001445 | n-[2-butyl-3-({4-[3-(dibutylamino)propoxy]p |
| 规格或纯度 | Moligand™, ≥98% |
| 英文名称 | Dronedarone |
| 生化机理 | 决奈达隆（Multaq）是一种较新的治疗药物，其结构与胺碘酮相似，但副作用较小；它是一种多通道阻滞剂，具有抗肾上腺素能特性，已在房颤治疗的心率和心律控制策略中进行了评估。 |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | K 抑制剂 v1.5 |
| 产品介绍 |
可作用于治疗阵发性和持续性房颤或房扑 |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 604-240-2 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide |
| INCHI | 1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3 |
| InChi Key | ZQTNQVWKHCQYLQ-UHFFFAOYSA-N |
| Smiles | CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC |
| Isomeric SMILES | CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC |
| 关联CAS | 141626-36-0 |
| MeSH Entry Terms | dronedarone;Multaq;SR 33589;SR 33589B |
| 分子量 | 556.77 |
| Reaxy-Rn | 8176529 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8176529&ln= |
| 溶解性 | DMSO |
|---|---|
| 分子量 | 556.800 g/mol |
| XLogP3 | 7.200 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 18 |
| 精确质量Exact Mass | 556.297 Da |
| 单同位素质量Monoisotopic Mass | 556.297 Da |
| 拓扑极表面积Topological Polar Surface Area | 97.200 Ų |
| 重原子数Heavy Atom Count | 39 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 800.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 F1509054 |
分析证书 | D126565 |
| 1. Bogdan R, Goegelein H, Ruetten H. (2011) Effect of dronedarone on Na+, Ca2+ and HCN channels.. Naunyn Schmiedebergs Arch Pharmacol, 383 (4): (347-56). [PMID:21279331] |
| 2. Sobrado LF, Varone BB, Machado AD, Nearing BD, Zeng D, Belardinelli L, Verrier RL. (2013) Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect.. J Cardiovasc Electrophysiol, 24 (8): (914-8). [PMID:23647933] |
| 3. Verrier RL, Sobrado MF, Pagotto VP, Kanas AF, Machado AD, Varone BB, Sobrado LF, Nearing BD, Zeng D, Belardinelli L. (2013) Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation.. Heart Rhythm, 10 (11): (1692-7). [PMID:23933296] |
| 4. Xynogalos P, Seyler C, Scherer D, Koepple C, Scholz EP, Thomas D, Katus HA, Zitron E. (2014) Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224.. Naunyn Schmiedebergs Arch Pharmacol, 387 (12): (1153-61). [PMID:25182566] |
| 5. Gómez R, Caballero R, Barana A, Amorós I, De Palm SH, Matamoros M, Núñez M, Pérez-Hernández M, Iriepa I, Tamargo J et al.. (2014) Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents.. Cardiovasc Res, 104 (2): (337-46). [PMID:25205296] |
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