3-羟基-萘-2-羧酸（3,4-二羟基-亚苄基）-酰肼

细胞渗透性动力抑制剂

10篇引用文献

COA

级别和纯度:

≥98%

CAS编号: 304448-55-3
分子式: C₁₈H₁₄N₂O₄
分子量: 322.31
MDL号: MFCD00292551
PubChem编号: 135533054
PubChem SID: 504773375

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货号 (SKU)	包装规格	是否现货
D125461-5mg	5mg	期货
D125461-10mg	10mg	现货
D125461-25mg	25mg	期货
D125461-50mg	50mg	期货
D125461-250mg	250mg	期货

查看相关系列

Anti-infection (2804) Autophagy (2848) Cytoskeleton (497) Dynamin (11) HSV (103) Virus (3767) 生物活性小分子 (17) 病毒蛋白酶 (106)

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基本描述

别名	3-羟基萘-2-羧酸(3,4-二羟基苯亚甲基)酰肼 \| N'-(3,4-二羟基苯亚甲基)-3-羟基-2-萘甲酰肼 \| 动力抑制剂I
英文别名	N'-[(E)-(3,4-dihydroxyphenyl)methylene]-3-hydroxy-2-naphthohydrazide \| cyclohexane-1,4-dicarboxylic acid;1,4-Cyclohexanedicarboxylic Acid \| N'-[(3,4-dihydroxyphenyl)methylidene]-3-hydroxynaphthalene-2-carbohydrazide \| EN300-97658 \| NCGC00259575-01 \| AKOS0
规格或纯度	≥98%
英文名称	Dynasore
生化机理	Dynasore 是一种 Dynamin I 和 Dynamin II 的非竞争性、细胞渗透性半咔唑酮化合物抑制剂。Dynamin家族成员，包括Dynamin I、Dynamin II和Dynamin III，都是GTP酶、微管相关蛋白，参与内吞、突触传递和神经发生。Dynamin I 定位于中枢神经系统，而 Dynamin II 则无处不在，在睾丸中的表达量最高。Dynasore 通过阻断包被囊泡的形成，对已知依赖于动态胺的内吞途径起到强效抑制作用。细胞渗透性动态素抑制剂，可阻断内吞。非竞争性抑制动态素 1、动态素 2 和线粒体动态素 GTPase 的活性。对其他小 GTP 酶具有选择性。
应用	An inhibitor of Dynamin I and Dynamin II
储存温度	避光,-20°C储存,充氩
运输条件	超低温冰袋运输
作用类型	抑制剂
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	Dynasore是一种可渗透细胞的，可逆的，非竞争性的dynamin（发动蛋白）抑制剂，抑制dynamin 1/2的GTPase活性，IC50为15 μM，也抑制线粒体dynamin Drp1，对其他小GTP酶没有作用效果。An inhibitor of Dynamin I and Dynamin II Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase An inhibitor of Dynamin I and Dynamin II
纯度	≥98%

关联靶点（人）

DNM1 Tbio Dynamin-1 (215 活性数据)

点击查看靶蛋白信息： DNM1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

DNM2 Tchem Dynamin-2 (62 活性数据)

点击查看靶蛋白信息： DNM2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CDC42SE1 Tdark CDC42 small effector protein 1 (3 活性数据)

点击查看靶蛋白信息： CDC42SE1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)

点击查看靶蛋白信息： Hdac6

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

COS-7 (515 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504773375
分子类型	小分子
IIUPAC Name	N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxynaphthalene-2-carboxamide
INCHI	1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
InChi Key	SYNDQCRDGGCQRZ-VXLYETTFSA-N
Smiles	C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3)O)O)O
Isomeric SMILES	C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O
分子量	322.31
Reaxy-Rn	20640593
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20640593&ln=

化学和物理性质

溶解性	Soluble in DMSO (100 mM), and ethanol (5 mM). Insoluble in water
敏感性	对热敏感；对光敏感
分子量	322.300 g/mol
XLogP3	3.600
氢键供体数Hydrogen Bond Donor Count	4
氢键受体数Hydrogen Bond Acceptor Count	5
可旋转键计数Rotatable Bond Count	3
精确质量Exact Mass	322.095 Da
单同位素质量Monoisotopic Mass	322.095 Da
拓扑极表面积Topological Polar Surface Area	102.000 Å²
重原子数Heavy Atom Count	24
形式电荷Formal Charge	0
复杂度Complexity	470.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	1
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	1
共价键合单元计数Covalently-Bonded Unit Count	1

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找到10个结果

批号(Lot Number)	证书类型	货号
C2525060	分析证书	D125461
D2313828	分析证书	D125461
L2425216	分析证书	D125461
C2525574	分析证书	D125461
I2203163	分析证书	D125461
I2203164	分析证书	D125461
A2510138	分析证书	D125461
L2322050	分析证书	D125461
I2203162	分析证书	D125461
C2225027	分析证书	D125461

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引用文献

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