5,15-二苯基卟啉

高效，选择性，细胞可渗透性STAT3抑制剂

COA

级别和纯度:

≥90%

CAS编号: 22112-89-6
分子式: C₃₂H₂₂N₄
分子量: 462.56
MDL号: MFCD08276335
PubChem编号: 10895852

有货

库存信息

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货号 (SKU)	包装规格	是否现货	价格	数量
D123123-100mg	100mg	期货

查看相关系列

JAK/STAT Signaling (508) STAT (138) Stem Cell/Wnt (1018) 材料合成砌块 (277) 给氮配体 (229)

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基本描述

别名	5,15-二苯基-21H,23H-卟吩 \| 5,15-二苯基卟
英文别名	BCP18710 \| FT-0682574 \| SCHEMBL2563180 \| D2860 \| 21H,23H-Porphine, 5,15-diphenyl- \| AKOS025394541 \| Stat3 Inhibitor VIII, 5,15-DPP \| HY-W035137 \| 5,15-Diphenylporphyrin \| BDBM50396176 \| J-014513 \| A878709 \| doi:10.14272/FNNOEKVUXXVPAI-DUVOQLPESA-N.1 \| MFC
规格或纯度	≥90%
英文名称	5,15-Diphenylporphyrin
生化机理	有效的，选择性的，细胞可渗透的STAT3抑制剂（K d = 880 nM）。抑制STAT3二聚化（STAT3 SH2域介导的配体结合和STAT1配体结合的IC 50值分别为0.28和10μM）。阻止TRAIL诱导的入侵。
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
作用类型	拮抗剂
备注	Solvents listed may be unsuitable for use in biological experiments. These solvents are intended to enable solubilisation and mixing of components. We recommend that biologically unsuitable solvents are removed prior to solubilisation in experimental media. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
纯度	≥90%

关联靶点（人）

STAT3 Tchem Signal transducer and activator of transcription 3 (3313 活性数据)

点击查看靶蛋白信息： STAT3

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Trypanosoma brucei brucei (13300 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Leishmania donovani (89745 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IIUPAC Name	10,20-diphenyl-21,22-dihydroporphyrin
INCHI	1S/C32H22N4/c1-3-7-21(8-4-1)31-27-15-11-23(33-27)19-25-13-17-29(35-25)32(22-9-5-2-6-10-22)30-18-14-26(36-30)20-24-12-16-28(31)34-24/h1-20,33,35H
InChi Key	QIBKIAFNCVIIMG-UHFFFAOYSA-N
Smiles	C1=CC=C(C=C1)C2=C3C=CC(=CC4=CC=C(N4)C(=C5C=CC(=N5)C=C6C=CC2=N6)C7=CC=CC=C7)N3
Isomeric SMILES	C1=CC=C(C=C1)C2=C3C=CC(=CC4=CC=C(N4)C(=C5C=CC(=N5)C=C6C=CC2=N6)C7=CC=CC=C7)N3
PubChem CID	10895852
分子量	462.56
Reaxy-Rn	3020011

化学和物理性质

分子量	462.500 g/mol
XLogP3	7.200
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	2
可旋转键计数Rotatable Bond Count	2
精确质量Exact Mass	462.184 Da
单同位素质量Monoisotopic Mass	462.184 Da
拓扑极表面积Topological Polar Surface Area	57.400 Å²
重原子数Heavy Atom Count	36
形式电荷Formal Charge	0
复杂度Complexity	657.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1