| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C655405-1ml |
1ml |
期货  |
|
| 规格或纯度 | 10mM in DMSO |
|---|---|
| 英文名称 | CXCR2-IN-2 |
| 生化机理 | CXCR2-IN-2 是一种具有选择性、脑穿透性和口服生物利用度的 CXCR2 拮抗剂（β-arrestin 试验/CXCR2 Tango 试验的 IC 50 分别为 5.2 nM/1 nM）。与 CXCR1 相比，CXCR2-IN-2 的选择性约为 730 倍，与其他所有 CXCR2 拮抗剂相比，其选择性约为 1900 倍。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 产品介绍 |
CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist ( IC 50 =5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC 50 of 0.04 μM In Vivo CXCR2-IN-2 (compound 68) (1-10 mg/kg; p.o.; twice daily for 3 days) dose-dependently reduces neutrophil infiltration in vivo in rat and mouse air pouch models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 week old male C57Bl/6 mice (Air Pouch Model in Mouse) Dosage: 1, 3, and 10 mg/kg Administration: P.o.; twice daily for 3 days Result: Significantly inhibited neutrophil infiltration into mouse air pouch. Animal Model: 8-10 week old male Wistar rats (Air Pouch Model in Rat) Dosage: 1, 3, and 10 mg/kg Administration: P.o.; twice daily for 3 days Result: Inhibited neutrophil migration to air pouch in rat. IC50& Target:CXCR2 5.2 nM (IC 50 ) CXCR1 3.8 μM (IC 50 ) |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | CC1=CCC[C@H]1NC(=O)NC2=C(C(=C(C=C2)Cl)S(=O)(=O)[C@]3(CCOC3)C)O |
| PubChem CID | 100951623 |
| 分子量 | 414.90 |
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