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Coralyne chloride

COA COA
    级别和纯度:
  • ≥98.0%
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
C649983-1mg
 1mg 期货 Stock Image
C649983-5mg
 5mg 期货 Stock Image
C649983-25mg
 25mg 期货 Stock Image
C649983-100mg
 100mg 期货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
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Cell Cycle (7376) Cell Cycle/DNA Damage (2603) Topoisomerase (149)
main product photo

基本描述

别名 氯雷他定 | 氯化柯喃炔水合物 | 柯楠因
英文别名 ?NSC-154890 | NSC96349 | NSC-96349 | Dibenzo(a,g)quinolizinium, 2,3,10,11-tetramethoxy-8-methyl-, chloride | Coralyne chloride | NSC154891 | NSC-154891 | NCGC00094866-01 | SR-05000002641-1 | DTXSID50959832 | BERBINIUM, 5,6,7,8,13,13a-HEXADEHYDRO-2,3,10,11
规格或纯度 ≥98.0%
英文名称 Coralyne chloride
生化机理 氯化矢车菊碱是一种原鸟嘌呤生物碱，具有很强的抗癌活性。氯化堇是一种强效拓扑异构酶 I 毒素，可诱导拓扑异构酶 I 介导的 DNA 断裂。氯化矢车菊烯可用于制备xa0矢车菊烯衍生物xa
储存温度 2-8°C储存,充氩,干燥
运输条件 冰袋运输
作用类型 抑制剂
产品介绍


Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes

In Vitro

Coralyne (6.25-100 μM; 24-72 hours) has cytotoxicity effect on breast cancer cell lines. It against MCF-7, MDA-MB-231 and MCF-10A cells with IC 50 s of 76.4 uM, 76.4 uM, and 99 uM,respectively at 24 hours. And it against MCF-7, MDA-MB-231 and MCF-10A cells with IC 50 s of 21.9 uM, 19.1 uM, and 91 μM, respectively at 72 hours. Coralyne (25 μM; 48 hours) significantly downregulates cancer cell attachment of MCF-7 and MDA-MB-231 compared to the untreated controls. The percent of reduction in adhesion of MCF-7 is 55%, whereas 53% in reduction in the adhesion of MDA-MB-23 and 62% in reduction of MCF-10A,respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Topoisomerase I
纯度 ≥98.0%

关联靶点（人）

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CAKI-1 (44928 活性数据)
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DU-145 (51482 活性数据)
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HL-60 (67320 活性数据)
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HT-29 (80576 活性数据)
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K562 (73714 活性数据)
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KM12 (47707 活性数据)
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MCF7 (126967 活性数据)
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MOLT-4 (49676 活性数据)
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OVCAR-3 (48710 活性数据)
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OVCAR-4 (44535 活性数据)
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OVCAR-5 (45555 活性数据)
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OVCAR-8 (47708 活性数据)
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PC-3 (62116 活性数据)
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RPMI-8226 (44974 活性数据)
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SF-295 (48000 活性数据)
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UACC-62 (47335 活性数据)
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作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 254-239-2
分子类型 小分子
IIUPAC Name 2,3,10,11-tetramethoxy-8-methylisoquinolino[2,1-b]isoquinolin-7-ium;chloride
INCHI 1S/C22H22NO4.ClH/c1-13-16-11-21(26-4)20(25-3)10-15(16)8-18-17-12-22(27-5)19(24-2)9-14(17)6-7-23(13)18;/h6-12H,1-5H3;1H/q+1;/p-1
InChi Key PDYBUYVOPAJLKP-UHFFFAOYSA-M
Smiles CC1=C2C=C(C(=CC2=CC3=[N+]1C=CC4=CC(=C(C=C43)OC)OC)OC)OC.[Cl-]
Isomeric SMILES CC1=C2C=C(C(=CC2=CC3=[N+]1C=CC4=CC(=C(C=C43)OC)OC)OC)OC.[Cl-]
关联CAS 38989-38-7,6872-73-7,38989-38-7 (chloride),6872-73-7 (Parent)
PubChem CID 23306
NSC Number 96349
MeSH Entry Terms coralyne;coralyne acetosulfate;coralyne chloride;coralyne sulfoacetate;NSC-154890
分子量 399.87

化学和物理性质

溶解性 H2O : 4 mg/mL (10.00 mM; ultrasonic and warming and heat to 60°C) DMSO : 1.82 mg/mL (4.55 mM; ultrasonic and warming and heat to 60°C)
敏感性 对湿度敏感
分子量 399.900 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 4
精确质量Exact Mass 399.124 Da
单同位素质量Monoisotopic Mass 399.124 Da
拓扑极表面积Topological Polar Surface Area 41.000 Ų
重原子数Heavy Atom Count 28
形式电荷Formal Charge 0
复杂度Complexity 503.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 2

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

溶液计算器

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