COH-SR4

COA

级别和纯度:

≥99%

CAS编号: 73439-19-7
分子式: C₁₃H₈Cl₄N₂O
分子量: 350.03
PubChem编号: 595311

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货号 (SKU)	包装规格	是否现货
C646549-25mg	25mg	期货
C646549-50mg	50mg	期货
C646549-100mg	100mg	期货

查看相关系列

AMPK (94) DNA Methylation (633) PI3K/Akt/mTOR (764) 表观遗传学 (1497)

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基本描述

规格或纯度	≥99%
英文名称	COH-SR4
生化机理	COH-SR4 是一种 AMPK 激活剂。COH-SR4 对白血病、黑色素瘤、乳腺癌和肺癌有很强的抗增殖活性。COH-SR4 通过激活 AMPK 抑制脂肪细胞分化。COH-SR4 可用于肥胖及其相关疾病的研究。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	COH-SR4 is an AMPK activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders In Vitro COH-SR4 (1-5 μM; 24 hours) results in a dose-dependent increase in the phosphorylation of AMPK and its substrate ACC in 3T3-L1 preadipocytes, as well as in cancer cells such as HL-60, HeLa, MCF-7. COH-SR4 (3-5 µM; 7 days) significantly inhibits 3T3-L1 adipocyte differentiation in a dose-dependent manner. COH-SR4 (1-5 μM; 24 hours) promotes cell G1 cycle arrest. COH-SR4 significantly reduces intracellular lipid accumulation and downregulates the expression of key adipogenesis-related transcription factors and lipogenic proteins. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: 3T3-L1 preadipocytes, HL-60 cells, HeLa cells, MCF-7 cells Concentration: 1 μM, 3 μM, 5 μM Incubation Time: 24 hours Result: Indirectly activated AMPK. Cell Cycle AnalysisCell Line: 3T3-L1 cells Concentration: 1 μM, 3 μM, 5 μM Incubation Time: 24 hours Result: Modulated the level of proteins active during S and G2 phases of the cell cycle. In Vivo COH-SR4 (5 mg/kg; i.g.; 3x/week; for 6 weeks) reduces body weight and fat mass in high fat diet (HFD) obese mice without affecting food intake. COH-SR4 improves glycemic control and dyslipidemia in HFD obese mice. COH-SR4 decreases adipose tissue hypertrophy and affects circulating adipokine levels in HFD obese mice. COH-SR4 prevents hepatic lipid accumulation and fatty liver in HFD obese mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Nine-week old male C57BL/6J miceDosage: 5 mg/kg Administration: Oral gavage, three times a week, for 6 weeks Result: Decreased body weight and fat mass in HFD obese mice. Form:Solid IC50& Target:AMPK
纯度	≥99%

关联靶点（人）

HL-60 (67320 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Plasmodium berghei (192651 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	未知
IIUPAC Name	1,3-bis(3,5-dichlorophenyl)urea
INCHI	1S/C13H8Cl4N2O/c14-7-1-8(15)4-11(3-7)18-13(20)19-12-5-9(16)2-10(17)6-12/h1-6H,(H2,18,19,20)
InChi Key	VKVJIWVUYNTBEZ-UHFFFAOYSA-N
Smiles	C1=C(C=C(C=C1Cl)Cl)NC(=O)NC2=CC(=CC(=C2)Cl)Cl
Isomeric SMILES	C1=C(C=C(C=C1Cl)Cl)NC(=O)NC2=CC(=CC(=C2)Cl)Cl
PubChem CID	595311
分子量	350.03

化学和物理性质

溶解性	DMSO : 125 mg/mL (357.11 mM; Need ultrasonic)
分子量	350.000 g/mol
XLogP3	5.000
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	1
可旋转键计数Rotatable Bond Count	2
精确质量Exact Mass	349.936 Da
单同位素质量Monoisotopic Mass	347.939 Da
拓扑极表面积Topological Polar Surface Area	41.100 Å²
重原子数Heavy Atom Count	20
形式电荷Formal Charge	0
复杂度Complexity	294.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

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