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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C586514-250mg |
250mg |
现货 ![]() |
| |
| C586514-1g |
1g |
现货 ![]() |
| |
| C586514-5g |
5g |
现货 ![]() |
| |
| C586514-25g |
25g |
现货 ![]() |
| |
| C586514-100g |
100g |
期货 ![]() |
|
| 别名 | 2-((4-(7-氯喹啉-4-基氨基)戊基)(乙基)氨基)乙醇 | 7-氯-4-[4-[N-乙基-N-(2-羟乙基)氨基]-1-甲基丁基氨基]喹啉 | N4-(7-氯-4-喹啉基)-N1-乙基-N1-(2-羟乙基)-1,4-戊二胺 |
|---|---|
| 英文别名 | Ethanol, 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)- | HY-W031727 | AB00053257_02 | NCGC00159483-06 | SPBio_001116 | 7-Chloro-4-(4-(N-ethyl-N-.beta.-hydroxyethylamino)-1-methylbutylamino)quinoline | Hydroxychloroquine (INN) | Oxichloroquine | ST |
| 规格或纯度 | Moligand™, ≥98% |
| 英文名称 | Hydroxychloroquine |
| 储存温度 | 2-8°C储存,避光,干燥 |
| 运输条件 | 冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | TLR7 拮抗剂;TLR9 拮抗剂 |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol |
| INCHI | 1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21) |
| InChi Key | XXSMGPRMXLTPCZ-UHFFFAOYSA-N |
| Smiles | CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO |
| Isomeric SMILES | CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO |
| 分子量 | 335.9 |
| Reaxy-Rn | 253894 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=253894&ln= |
| 分子量 | 335.900 g/mol |
|---|---|
| XLogP3 | 3.600 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 9 |
| 精确质量Exact Mass | 335.176 Da |
| 单同位素质量Monoisotopic Mass | 335.176 Da |
| 拓扑极表面积Topological Polar Surface Area | 48.400 Ų |
| 重原子数Heavy Atom Count | 23 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 331.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P330: 漱口 P501: 将内容物/容器处理到。。。 P301+P317: 如果被吞咽:请寻求医疗帮助。 |
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | C586514 | |
| 分析证书 | C586514 | |
| 分析证书 | C586514 | |
| 分析证书 | C586514 | |
| 分析证书 | C586514 | |
| 分析证书 | C586514 | |
| 分析证书 | C586514 | |
| 分析证书 | C586514 | |
| 分析证书 | C586514 | |
| 分析证书 | C586514 | |
| 分析证书 | C586514 | |
| 分析证书 | C586514 | |
| 分析证书 | C586514 |
| 1. Biot C, Daher W, Chavain N, Fandeur T, Khalife J, Dive D, De Clercq E. (2006) Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.. J Med Chem, 49 (9): (2845-9). [PMID:16640347] |
| 2. Kawai T, Akira S. (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.. Nat Immunol, 11 (5): (373-84). [PMID:20404851] |
| 3. Silva JC, Mariz HA, Rocha Jr LF, Oliveira PS, Dantas AT, Duarte AL, Pitta Ida R, Galdino SL, Pitta MG. (2013) Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients.. Clinics (Sao Paulo), 68 (6): (766-71). [PMID:23778483] |
| 4. Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, Doudier B, Courjon J, Giordanengo V, Vieira VE et al.. (2020) Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.. Int J Antimicrob Agents, 56 (1): (105949). [PMID:32205204] |
| 5. Rosenberg ES, Dufort EM, Udo T, Wilberschied LA, Kumar J, Tesoriero J, Weinberg P, Kirkwood J, Muse A, DeHovitz J et al.. (2020) Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State.. JAMA, 323 (24): (2493-2502). [PMID:32392282] |
| 6. Dai Yan, Sang Xiu-Bo, Bai Wen-Pei. (2023) N-acetylcysteine and Hydroxychloroquine Ameliorate ADMA-Induced Fetal Growth Restriction in Mice via Regulating Oxidative Stress and Autophagy. Reproductive Sciences, (1-12). [PMID:37845590] [10.1007/s43032-023-01380-z] |
| 7. Mu Jiaxiang, Meng Zhaoxu, Liu Xinran, Guan Ping, Lian He. (2023) Implantable Nanofiber Membranes with Synergistic Photothermal and Autophagy Inhibition Effects for Enhanced Tumor Therapy Efficacy. Advanced Fiber Materials, (1-16). [10.1007/s42765-023-00311-6] |
| 8. Lan-Yi Hu, Ye Yuan, Zi-Xuan Wen, Yi-Yue Hu, Miao-Miao Yin, Yan-Jun Hu. (2023) Affinity binding of COVID-19 drug candidates (chloroquine/hydroxychloroquine) and serum albumin: Based on photochemistry and molecular docking. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 240 (112667). [PMID:36753782] [10.1016/j.jphotobiol.2023.112667] |
| 9. Jingxiang Zhao, Zhiqiang Zhao, Wanting Hou, Yue Jiang, Guobin Liu, Xuelian Ren, Kun Liu, Hong Liu, Kaixian Chen, He Huang. (2022) Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine. MOLECULES, 27 (16): (5175). [PMID:36014414] [10.3390/molecules27165175] |
| 10. Zhang Man, Bai Yang, Xu Chang, Qi Yiying, Meng Jiahong, Zhang Wenkan, Su Hang, Yan Weiqi. (2021) Blockage of Extracellular Signal-Regulated Kinase Exerts an Antitumor Effect via Regulating Energy Metabolism and Enhances the Efficacy of Autophagy Inhibitors by Regulating Transcription Factor EB Nuclear Translocation in Osteosarcoma. Frontiers in Cell and Developmental Biology, 9 (1873). [PMID:34414176] [10.3389/fcell.2021.650846] |
| 11. Rongliang Wang, Jiawei Li, Xingquan Xu, Jia Xu, Huiming Jiang, Zhongyang Lv, Rui Wu, Ziying Sun, Wenjie Guo, Yang Sun, Shiro Ikegawa, Qing Jiang, Dongquan Shi. (2021) Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model. Journal of Orthopaedic Translation, 29 (89). [PMID:34094861] [10.1016/j.jot.2021.05.001] |
| 12. Xingquan Xu, Rongliang Wang, Rui Wu, Wenjin Yan, Tianshu Shi, Qing Jiang, Dongquan Shi. (2020) Trehalose reduces bone loss in experimental biliary cirrhosis rats via ERK phosphorylation regulation by enhancing autophagosome formation. FASEB JOURNAL, 34 (6): (8402-8415). [PMID:32367591] [10.1096/fj.201902528RRR] |
| 13. Chen Ping, Zhang Xueer, Fang Qiaomiao, Zhao Zhongxiang, Lin Chaozhan, Zhou Yuan, Liu Fangle, Zhu Chenchen, Wu Aizhi. (2024) Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo. Journal of Natural Medicines, (1-16). [PMID:38403724] [10.1007/s11418-024-01782-6] |
| 14. Boqiang Gao, Haoge Liang, Jie Wang, Yan Huang, Jingzhen Wang, Jia Song, Pan Hu, Hu Yang, Shuanglong Ma. (2025) Efficient adsorption of hydroxychloroquine by carboxylated lignin-based sponge: Quantification of the adsorption contribution of interactions. SEPARATION AND PURIFICATION TECHNOLOGY, 354 (129359). [10.1016/j.seppur.2024.129359] |
| 15. Zhipeng Zhang, Huizi Zheng, Ying Liu, Shuang Ma, Qi Feng, Jiao Qu, Xiaolin Zhu. (2024) Highly sensitive detection of multiple antiviral drugs using graphitized hydroxylated multi-walled carbon nanotubes/ionic liquids-based electrochemical sensors. ENVIRONMENTAL RESEARCH, 249 (118466). [PMID:38354882] [10.1016/j.envres.2024.118466] |
| 16. Linming Li, Yan Chen, Ming Zhang, Suying Li, Shuaiqi Feng, Yan-Qin He, Ning Zhang, Zhifang Liu, Meifeng Liu, Qing-Peng Wang. (2024) Hydroxychloroquine Platinum(IV) Conjugate Displaying Potent Antimetastatic Activities by Suppressing Autophagy to Improve the Tumor Microenvironment. DALTON TRANSACTIONS, [PMID:39092626] [10.1039/D4DT01794C] |