| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C425902-1ml |
1ml |
现货  |
|
| 别名 | 卡百戊烷 |
|---|---|
| 英文别名 | Cyclopentanecarboxylic acid, 1-phenyl-, 2-[2-(diethylamino)ethoxy]ethyl ester | MS-25033 | PENTOXYVERINE [WHO-DD] | SDCCGSBI-0050301.P004 | EN300-18551609 | KBio3_001924 | SBI-0050301.P003 | Spectrum2_001412 | 32C726X12W | CHEBI:94484 | PENTOXYVERINE [HSD |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Carbetapentane |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Carβpentane是σ位的无卵小分子激动剂，可产生镇咳药和抗惊厥药的作用。描述了Carβpentane保护大鼠免受最大的电击诱发的癫痫发作。一项研究表明，Carβpentane对红藻氨酸诱导的神经毒性的减弱被sigma-1受体拮抗剂所取代，这表明Carβpentane通过其sigma位点结合活性产生了神经保护作用。还报道了对毒蕈碱受体的结合活性，尽管Carβpentane不能提供针对NMDA杀伤力的保护，因此不能证明归因于密切相关的镇咳药和惊厥药右美沙芬的NMDA拮抗作用。Carβpentane是KO Carbetapentane is a non-opiod small molecule agonist of sigma sites, producing antitussive and anticonvulsant effects. Carbetapentane is described to protect rats against maximal electroshock-induced seizures. A study demonstrates that the attenuation of kainic acid-induced neurotoxicity by Carbetapentane is overriden by a sigma-1 receptor antagonist, indicating that Carbetapentane produces neuroprotection through its sigma site binding activity. Binding activity on muscarinic receptors is also reported, though Carbetapentane did not provide protection against NMDA lethality and therefore does not demonstrate the NMDA-antagonist action ascribed to the closely related antitussive and anticonvulsant Dextromethorphan . Carbetapentane is an inhibitor of KOR-3 and an activator of Sigma Receptor. |
| pKa值 | pKₐ: 9.69 (Predicted) |
|---|---|
| Ki Data | [3H]- -(+)3 PPP: Ki= 0.01 μM; [3H]- dextromethorphan : Ki= 0.01 μM; [3H]pentazocine radioligand : Ki= 0.02 μM; [3H]- - (+) pentazocine : Ki= 0.03 μM |
| IC50 | [3H]- (+) - pentazocine : IC₅₀= 0.03 μM (rat); Antiproliferative activity against mouse neural precursor cells by MTT assay: EC5050 = 0.77 μM (mouse) |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 201-014-1 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 2-[2-(diethylamino)ethoxy]ethyl 1-phenylcyclopentane-1-carboxylate |
| INCHI | 1S/C20H31NO3/c1-3-21(4-2)14-15-23-16-17-24-19(22)20(12-8-9-13-20)18-10-6-5-7-11-18/h5-7,10-11H,3-4,8-9,12-17H2,1-2H3 |
| InChi Key | CFJMRBQWBDQYMK-UHFFFAOYSA-N |
| Smiles | CCN(CC)CCOCCOC(=O)C1(CCCC1)C2=CC=CC=C2 |
| Isomeric SMILES | CCN(CC)CCOCCOC(=O)C1(CCCC1)C2=CC=CC=C2 |
| 分子量 | 333.47 |
| Beilstein号 | 2299701 |
| Reaxy-Rn | 2299701 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2299701&ln= |
| 折光率 | n20D1.52 (Predicted) |
|---|---|
| 沸点 | ~435.5° C at 760 mmHg (Predicted) |
| 熔点 | 138.42° C (Predicted) |
| 分子量 | 333.500 g/mol |
| XLogP3 | 3.800 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 11 |
| 精确质量Exact Mass | 333.23 Da |
| 单同位素质量Monoisotopic Mass | 333.23 Da |
| 拓扑极表面积Topological Polar Surface Area | 38.800 Ų |
| 重原子数Heavy Atom Count | 24 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 356.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| RTECS | GY3500000 |
|---|---|
| Merck Index | 1.82916666666667 |
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