| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C422987-1ml |
1ml |
现货  |
|
| 别名 | 2-氰基-3-(4-羟苯基)丙烯酸 |
|---|---|
| 英文别名 | NCGC00094622-01 | AMY11197 | BRD-K60302405-001-02-9 | Dimethiotazine | DTXSID501018295 | MLS002207285 | (2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid | 2-Cyano-3-(4-hydroxyphenyl)propenoic acid | 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid | a-Cyano- |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | α-Cyano-4-hydroxycinnamic Acid |
| 生化机理 | 单羧酸转运（MCT）抑制剂。表现出抗肿瘤和抗血管生成胶质瘤的活性。减少U251细胞中的糖酵解代谢，迁移和侵袭。增强DNA甲基化抗肿瘤剂替莫唑的作用 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 线粒体丙酮酸载体 1 抑制剂；线粒体丙酮酸载体 2 抑制剂 |
| 产品介绍 |
Product Introduction α-Cyano-4-hydroxycinnamic acid is the commonly used matrix for analyzing peptides by matrix-assisted laser desorption/ionization mass spectrometry. It inhibits the monophenolase activity and diphenolase activity of mushroom tyrosinase. Application α-Cyano-4-hydroxycinnamic acid (CHC) was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid |
| INCHI | 1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+ |
| InChi Key | AFVLVVWMAFSXCK-VMPITWQZSA-N |
| Smiles | C1=CC(=CC=C1C=C(C#N)C(=O)O)O |
| Isomeric SMILES | C1=CC(=CC=C1/C=C(\C#N)/C(=O)O)O |
| 分子量 | 189.17 |
| Beilstein号 | 3271430 |
| Reaxy-Rn | 8201999 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8201999&ln= |
| 熔点 | 245-250℃ |
|---|---|
| 分子量 | 189.170 g/mol |
| XLogP3 | 1.400 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 189.043 Da |
| 单同位素质量Monoisotopic Mass | 189.043 Da |
| 拓扑极表面积Topological Polar Surface Area | 81.300 Ų |
| 重原子数Heavy Atom Count | 14 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 292.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| 个人防护装备 | dust mask type N95 (US)， Eyeshields， Gloves |
| 1. Xiaoyu Yuan, Jiayi Song, Han Wang, Wenkang Zhang, Ying Liu, Ping Su, Yi Yang. (2024) Dual-functionalized two-dimensional metal–organic framework composite with highly hydrophilicity for effective enrichment of glycopeptides. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1232 (123920). [PMID:38101285] [10.1016/j.jchromb.2023.123920] |
| 2. Chenhui Lu, Haodong Wei, Lizhi Xu, Wen-Long Wang, Cheng Yang, Xueli Shi, Hui Gao, Yong-Wei Feng, Jianzhong Zhou, Yi Zhang. (2024) Enrichment of sialic acid-containing casein glycomacropeptide in protein hydrolysates using phenylboronic acid-functionalized mesoporous silica nanoparticles. TALANTA, 267 (125174). [PMID:37708769] [10.1016/j.talanta.2023.125174] |
| 3. Lei Wang, Yuhao Han, Yaqi Zhang, Haoyuan Geng, Zihan Zhu, Panpan Chen, Xiaoqing Cui, Xiao Wang, Chenglong Sun. (2023) In-depth profiling of carbohydrate isomers in biological tissues by chemical derivatization-assisted mass spectrometry imaging. ANALYTICA CHIMICA ACTA, 1278 (341741). [PMID:37709472] [10.1016/j.aca.2023.341741] |
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