| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C422711-1ml |
1ml |
现货  |
|
| 别名 | (+)-儿茶精 |
|---|---|
| 英文别名 | 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, monohydrate, (2R,3S)- | (+/-)-Catechin hydrate, primary pharmaceutical reference standard | (2R,3S)-2-(3,4-Dihydroxyphenyl)-chroman-3,5,7-triol hydrate | (2R,3S)-2-(3,4-Dihydroxyphenyl)chroman-3 |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | (+)-Catechin Hydrate |
| 生化机理 | 植物来源的类黄酮抗氧化剂，一种自由基清除剂，以防止自由基介导的生物系统中的各种损伤。例如，在生理pH条件下，儿茶素抑制羟基自由基的DNA链断裂。它也被实验证实防止人体血浆氧化。延迟内源性的脂溶性抗氧化剂的消耗和抑制脂质过氧化。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
(+)-Catechin monohydrate is an antioxidant flavonoid that is a free radical scavenger. Research shows that it is relatively nontoxic to cells at high doses. (+)-Catechin can stop ultraviolet B induced human keratinocyte death through the inhibition of JNK phosphorylation. Literature indicates that it may have Ca2+ antagonistic activity. (+)-Catechin monohydrate is an inhibitor of Cox-1. (+)-Catechin monohydrate is an antioxidant flavonoid that is a free radical scavenger. Research shows that it is relatively nontoxic to cells at high doses. (+)-Catechin can stop ultraviolet B induced human keratinocyte death through the inhibition of JNK phosphorylation. Literature indicates that it may have Ca2+ antagonistic activity. (+)-Catechin monohydrate is an inhibitor of Cox-1. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 205-825-1 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol;hydrate |
| INCHI | 1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-5,13,15-20H,6H2;1H2/t13-,15+;/m0./s1 |
| InChi Key | OFUMQWOJBVNKLR-NQQJLSKUSA-N |
| Smiles | C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O.O |
| Isomeric SMILES | C1[C@@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O.O |
| 关联CAS | 154-23-4 |
| 分子量 | 290.27 |
| Beilstein号 | 3595244 |
| Reaxy-Rn | 31285846 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31285846&ln= |
| 熔点 | 96°C(lit.) |
|---|---|
| 分子量 | 308.280 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 6 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 308.09 Da |
| 单同位素质量Monoisotopic Mass | 308.09 Da |
| 拓扑极表面积Topological Polar Surface Area | 111.000 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 364.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 2 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | DJ3450000 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
| 1. Zijian Liang, Pangzhen Zhang, Wen Ma, Xin-An Zeng, Zhongxiang Fang. (2024) Physicochemical properties, antioxidant activities and comprehensive phenolic profiles of tea-macerated Chardonnay wine and model wine. FOOD CHEMISTRY, 436 (137748). [PMID:37862991] [10.1016/j.foodchem.2023.137748] |
| 2. Tong Jiang, Hong Wang, Peihua Xu, Yifan Yao, Yilong Ma, Zhaojun Wei, Xiangli Niu, Yafang Shang, Dong Zhao. (2023) Effect of grape seed proanthocyanidin on the structural and physicochemical properties of bread during bread fermentation stage. Current Research in Food Science, 7 (100559). [PMID:37600464] [10.1016/j.crfs.2023.100559] |
| 3. Mao-Ling Luo, Hua Chen, Guo-Ying Chen, Shengpeng Wang, Yitao Wang, Feng-Qing Yang. (2023) Preparation of Alcohol Dehydrogenase–Zinc Phosphate Hybrid Nanoflowers through Biomimetic Mineralization and Its Application in the Inhibitor Screening. MOLECULES, 28 (14): (5429). [PMID:37513303] [10.3390/molecules28145429] |
| 4. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou. (2023) Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 292 (122380). [PMID:36736046] [10.1016/j.saa.2023.122380] |
| 5. Shuai Zhang, Qin Ma, Lihong Dong, Xuchao Jia, Lei Liu, Fei Huang, Guang Liu, Zhida Sun, Jianwei Chi, Mingwei Zhang, Ruifen Zhang. (2022) Phenolic profiles and bioactivities of different milling fractions of rice bran from black rice. FOOD CHEMISTRY, 378 (132035). [PMID:35042109] [10.1016/j.foodchem.2021.132035] |
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| 8. Mengting Wang, Jinyuan Shi, Lei Wang, Yaqin Hu, Xingqian Ye, Donghong Liu, Jianchu Chen. (2018) Inhibitory kinetics and mechanism of flavonoids from lotus (Nelumbo nucifera Gaertn.) leaf against pancreatic α-amylase. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 120 (2589). [PMID:30195612] [10.1016/j.ijbiomac.2018.09.035] |
| 9. Juan Xu, Hongpo Zhou, Kun Li, Jinju Ma, Wenwen Zhang, Lanxiang Liu, Yanlin Sun, Hong Zhang, Kai Li. (2018) Multi-scale pectin/polyphenol beads for non-fouling fluorescence tracking on soft matter under water. CARBOHYDRATE POLYMERS, 199 (186). [PMID:30143119] [10.1016/j.carbpol.2018.07.021] |
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