| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C422313-1ml |
1ml |
现货  |
|
| 别名 | 西仑吉肽 | 西仑吉肽 |
|---|---|
| 英文别名 | NSC 707544 | DTXSID9044035 | c(RGDfMeV) | HY-16141 | 4EDF46E4GI | Cilengitide | Cilengitide [USAN:INN] | EMD121974 | EMD-121974 | HALOFANTRINE HYDROCHLORIDE [MART.] | Cyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl) | NCGC00386242-02 | AC |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Cilengitide |
| 生化机理 | 整合素αvβ3和αvβ5的有效抑制剂和选择性抑制剂（IC50值分别为4.1和70 nM）。与gpIIb / IIIa相比，具有约10倍的选择性。增加内皮细胞单层通透性。还表现出抗血管生成活性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | Integrin alpha-V/beta-5 拮抗剂 |
| 产品介绍 |
Cilengitide是一种有效的integrin（整合素）抑制剂，作用于αvβ3受体和αvβ5受体，IC50分别为4.1 nM和79 nM，比作用于gpIIbIIIa选择性高10倍左右。 Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM, respectively; ~10-fold selectivity against gpIIbIIIa. |
| ALogP | -1 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 蛋白质 |
|---|---|
| IIUPAC Name | 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid |
| INCHI | 1S/C27H40N8O7/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30)/t17-,18-,19+,22-/m0/s1 |
| InChi Key | AMLYAMJWYAIXIA-VWNVYAMZSA-N |
| Smiles | CC(C)C1C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N |
| Isomeric SMILES | CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N |
| 分子量 | 588.66 |
| Reaxy-Rn | 27344515 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27344515&ln= |
| 分子量 | 588.700 g/mol |
|---|---|
| XLogP3 | -1.000 |
| 氢键供体数Hydrogen Bond Donor Count | 7 |
| 氢键受体数Hydrogen Bond Acceptor Count | 8 |
| 可旋转键计数Rotatable Bond Count | 9 |
| 精确质量Exact Mass | 588.302 Da |
| 单同位素质量Monoisotopic Mass | 588.302 Da |
| 拓扑极表面积Topological Polar Surface Area | 238.000 Ų |
| 重原子数Heavy Atom Count | 42 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1020.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 4 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. Ying Song, Chen Li, Yahan Fu, Qiu Xie, Jun Guo, Guangming Li, Huiwen Wu. (2020) Inward Tension of Talin and Integrin-related Osmotic Pressure are involved Synergetically in the Invasion and Metastasis of Non-small Cell Lung Cancer. Journal of Cancer, 11 (17): ( 5032–5041). [PMID:32742451] [10.7150/jca.45494] |
| 2. Yifan Wang, Xiaolong Zhang, Jilai Tian, Jinjun Shan, Yunfeng Hu, Yiqian Zhai, Jun Guo. (2019) Talin promotes integrin activation accompanied by generation of tension in talin and an increase in osmotic pressure in neurite outgrowth. FASEB JOURNAL, 33 (5): (6311-6326). [PMID:30768370] [10.1096/fj.201801949RR] |
| 3. Siming Yu, Linna Li, Wei Tian, Dan Nie, Wei Mu, Fang Qiu, Yu Liu, Xinghan Liu, Xiaofeng Wang, Zhimin Du, Wen-Feng Chu, Baofeng Yang. (2018) PEP06 polypeptide 30 exerts antitumour effect in colorectal carcinoma via inhibiting epithelial–mesenchymal transition. BRITISH JOURNAL OF PHARMACOLOGY, 175 (15): (3111-3130). [PMID:29722931] [10.1111/bph.14352] |
| 4. Wenli Jiang, Xinghong Yao, Jian Zhong, Zhi Ouyang, Junyi Shen, Yan Qiu, Ye Zeng. (2024) Spatial confinement modulates endothelial cell behavior and traction force in 3D hydrogel microgrooves. Materials Today Bio, 26 (101074). [PMID:38736613] [10.1016/j.mtbio.2024.101074] |
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