| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C408691-1ml |
1ml |
现货  |
|
| 英文别名 | SQ 14225 | (S)-1-((S)-3-mercapto-2-methylpropanoyl)pyrrolidine-2-carboxylic acid |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Captopril |
| 生化机理 | 卡托普利（SQ 14225）是一种血管紧张素转换酶（ACE）抑制剂，IC50 为 6 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 血管紧张素转换酶抑制剂 |
| 产品介绍 |
Captopril is a reversible and competitive inhibitor of leukotriene A4 hydrolase (LTA4H; IC50 = 11μM). Captopril has been shown to be an inhibitor of angiotensin converting enzyme-1 (ACE1), but not ACE2 (IC50 = 22 nM). Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity. Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.Captopril是一种血管紧张素转换酶（ACE）抑制剂，IC50为6 nM。 Information Captopril (SQ 14225) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM. In vivo
cell lines： Concentrations： Incubation Time： Powder Purity:≥99% |
| ALogP | 0.3 |
|---|
| EC号 | 263-607-1 |
|---|---|
| 分子类型 | 小分子 |
| Isomeric SMILES | C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O |
| 分子量 | 217.29 |
| Beilstein号 | 477887 |
| Reaxy-Rn | 3651421 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3651421&ln= |
| 溶解性 | Solubility (25°C) In vitro DMSO: 30 mg/mL (197.17 mM); Ethanol: -1 mg/mL |
|---|---|
| 比旋光度 | -127.5° |
| 熔点 | 106°C |
| 象形图 | GHS08, GHS05, GHS07 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H318: 造成严重的眼睛损伤 H317: 可能引起皮肤过敏反应 H360: 可能损害生育力或未出生的孩子 H361: 怀疑破坏生育力或未出生的孩子 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P203: 使用前，获取、阅读并遵守所有安全说明。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P318: 如果暴露或担心，请就医。 P317: 寻求紧急医疗救助。 |
| WGK Germany | 3 |
| RTECS | UY0550000 |
| Merck Index | 1774 |
| 个人防护装备 | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| 1. Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo. (2024) Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 126 (105825). [10.1016/j.jfca.2023.105825] |
| 2. Yanan Guan, Yueyue Zu, Pengyi Ma, Shutao Li, Qi Ma, Jinping Song, Yong Guo. (2023) Cascade Fluorescent Determination of Mercury (II) and Captopril Using Tungsten-Nitrogen Doped Carbon Dots. ANALYTICAL LETTERS, [10.1080/00032719.2023.2180802] |
| 3. Jing Zhu, Lei Hu, Xiangying Meng, Feng Li, Wenjuan Wang, Guiyang Shi, Zhongxia Wang. (2023) Synergism of Photo-Induced Electron Transfer and Aggregation-Induced Quenching Mechanisms for Highly Sensitive Detection of Silver Ion and Captopril. MOLECULES, 28 (9): (3650). [PMID:37175061] [10.3390/molecules28093650] |
| 4. Xuwen Gao, Xiancheng Liu, Ying Zeng, Qingqing Zhang, Bin Zhang, Guizheng Zou. (2022) Spectrum-Resolved Electrochemiluminescence to Multiplex the Immunoassay and DNA Probe Assay. ANALYTICAL CHEMISTRY, 94 (45): (15801–15808). [PMID:36334096] [10.1021/acs.analchem.2c03579] |
| 5. Kun Liu, Xiaohan Zhang, Xiongfeng Zhou, Xinming Huo, Xiaohao Wang, Kostya (Ken) Ostrikov. (2022) Experimental investigation of an atmospheric pressure plasma jet as an ion source for on-site mass-spectrometry analysis of nonvolatile solid samples: the integration effect of thermal desorption and ionization. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 55 (48): (485202). [10.1088/1361-6463/ac968a] |
| 6. Wang Yiran, Shi Jihua, Dai Dapeng, Cai Jianping, Wang Shuanghu, Hong Yun, Zhou Shan, Zhao Fangling, Zhou Quan, Geng Peiwu, Zhou Yunfang, Xu Xue, Luo Qingfeng. (2022) Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo. Frontiers in Pharmacology, 13 [PMID:36052128] [10.3389/fphar.2022.909168] |
| 7. Lixia Han, Ting Liu, Di Cui, Jiaqi Yi, Wei Jiang, Xiaoshuang Li, Na Niu, Ligang Chen. (2022) Quantitative detection of captopril in urine by smartphone-assisted ratiometric fluorescence sensing platform. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 280 (121562). [PMID:35780761] [10.1016/j.saa.2022.121562] |
| 8. Shuangtian Dong, Dongyang Wang, Xuwen Gao, Li Fu, Jingna Jia, Yuqi Xu, Bin Zhang, Guizheng Zou. (2022) Glow and Flash Adjustable Chemiluminescence with Tunable Waveband from the Same CuInS2@ZnS Nanocrystal Luminophore. ANALYTICAL CHEMISTRY, 94 (18): (6902–6908). [PMID:35486816] [10.1021/acs.analchem.2c01083] |
| 9. Cheng-Yuan Dong, Sheng Hong, Di-Wei Zheng, Qian-Xiao Huang, Fu-Sheng Liu, Zhen-Lin Zhong, Xian-Zheng Zhang. (2020) Multifunctionalized Gold Sub-Nanometer Particles for Sensitizing Radiotherapy against Glioblastoma. Small, 17 (5): (2006582). [PMID:33382206] [10.1002/smll.202006582] |
| 10. Zhong-Xia Wang, Xing Jin, Wen-Juan Wang, Fen-Ying Kong, Jing Zhu, Heng-Ye Li, Yu-Jie Ding, Wei Wang. (2021) Green synthesis of a deep-ultraviolet carbonized nanoprobe for ratiometric fluorescent detection of feroxacin and enrofloxacin in food and serum samples. ANALYST, 146 (3): (874-881). [PMID:33241796] [10.1039/D0AN02114H] |
| 11. Yang Xu, Jin Li, Jian Zhou, Yufeng Liu, Zhuojun Wei, Hui Zhang. (2020) Layered double hydroxides supported atomically precise Aun nanoclusters for air oxidation of benzyl alcohol: Effects of size and active site structure. JOURNAL OF CATALYSIS, 389 (409). [10.1016/j.jcat.2020.06.017] |
| 12. Tian Ruochen, Suo Hao, Zhang Shuting, Sun Baoshan. (2020) Separation of a family of antioxidants flavan-3-ol thio-conjugates from procyanidins by high-speed counter-current chromatography. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 246 (5): (1017-1029). [10.1007/s00217-020-03465-4] |
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