| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C407797-1ml |
1ml |
现货  |
|
| 英文别名 | NSC 169864 | 5H-Dibenz[b,f]azepine-5-carboxamide |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Carbamazepine |
| 生化机理 | 卡马西平（Carbatrol，NSC 169864）是一种钠通道阻滞剂，在大鼠脑突触体中的 IC50 值为 131 μM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 封闭剂 |
| 作用机制 | 钠通道α亚基阻断剂 |
| 产品介绍 |
Carbamazepine 是一种具有口服活性的压敏钠离子通道阻断剂，IC50 为 131 μM。Carbamazepine 可阻断电压门控 Na+、Ca2+ 和 K+ 通道，也是一种 HDAC 抑制剂 (IC50: 2 μM)。Carbamazepine 是一种抗惊厥试剂，可用于癫痫和神经性疼痛的研究。 Information Carbamazepine Carbamazepine (Carbatrol, NSC 169864) is a sodium channel blocker with IC50 of 131 μM in rat brain synaptosomes. Carbamazepine inhibits the binding of [3H]batrachotoxinin A 20-α-benzoate (BTX-B) to a receptor site of voltage-sensitive sodium channel with IC50 of 131 μM, to decrease the activation of sodium channel ion flux in rat brain synaptosomes. Carbamazepine reduces receptor affinity due to an increased rate of ligand dissociation from the receptor-ligand complex, without altering maximal binding capacity from the scatchard analysis of BTX-B binding to synaptosome, suggesting an indirect allosteric mechanism for anticonvulsant inhibition of BTX-B binding. Carbamazepine does not alter basal 125I-labeled scorpion toxin binding to synaptosomes in the absence of batrachotoxin, but when batrachotoxin (1.25 μM) added, Carbamazepine inhibits the batrachotoxin-dependent increase in scorpion toxin binding in a concentration-dependent manner with IC50 of 260 μM mediated at the alkaloid toxin binding site, none of which affects [3H]saxitoxin binding. In vivo Carbamazepine at 25 mg/kg significantly increases extracellular levels of striatal and hippocampal dopamine (DA), 3,4-dihydroxyphenylalanine (DOPA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in a dose dependent manner, while Carbamazepine at 50 mg/kg significantly decreases total levels of striatal DA and DOPA as well as hippocampal HVA, but has no effect on total levels of striatal DOPAC and HVA nor on hippocampal DA, DOPA and DOPAC. Intraperitoneal administration of Carbamazepine （~100 mg/kg）to rats produces significant increases in the cerebral cortical concentrations of neuroactive steroids and neuroactive steroids in plasma in a dose and time dependent maner with DHEA formed as a result of side chain cleavage of pregnenolone not affected. cell lines： Concentrations： Incubation Time： Powder Purity:≥99% |
| ALogP | 2.5 |
|---|
| Isomeric SMILES | C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N |
|---|---|
| 分子量 | 236.27 |
| Reaxy-Rn | 1246090 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1246090&ln= |
| 熔点 | 191 °C |
|---|
| 象形图 | GHS08, GHS07 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H302: 吞食有害 H317: 可能引起皮肤过敏反应 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P284: 如果通风不良，请佩戴呼吸防护装置。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。 P342+P316: 如果出现呼吸道症状：立即寻求急救。 |
| Merck Index | 1781 |
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| 53. Yuchen Zhang, Peng Zhou, Rongfu Huang, Chenying Zhou, Yang Liu, Heng Zhang, Xiaowei Huo, Jian Zhao, Zhaokun Xiong, Bo Lai. (2023) Iron boride boosted Fenton oxidation: Boron species induced sustainable FeIII/FeII redox couple. JOURNAL OF HAZARDOUS MATERIALS, 443 (130386). [PMID:36444072] [10.1016/j.jhazmat.2022.130386] |
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