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DL-4-氯苯丙氨酸, 左旋苯丙氨酸羟化酶抑制剂；左旋色氨酸羟化酶 1 抑制剂；左旋色氨酸羟化酶 2 抑制剂

色氨酸羟化酶抑制剂
13篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
C136727-1g
 1g 现货 Stock Image
C136727-5g
 5g 现货 Stock Image
C136727-25g
 25g 现货 Stock Image
C136727-100g
 100g 期货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
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Amino Acid/Protein Metabolism (4559) Amino acids (56) L-Phenylalanine hydroxylase Inhibitor (2) L-Tryptophan hydroxylase 1 Inhibitor (7) L-Tryptophan hydroxylase 2 Inhibitor (4) Metabolic Enzyme/Protease (4889) Tryptophan Hydroxylase (14) 非蛋白氨基酸 (12)
main product photo

基本描述

别名 4-氯-DL-苯基丙氨酸 | 芬克洛宁 | 4-氯-DL-苯丙氨酸 | 2-氨基-3-(4-氯苯基)丙酸
英文别名 2-amino-3-(4-chlorophenyl)propanoic acid | Fenchlonine | C-Pal | DL-3-(p-Chlorophenyl)alanine | DL-p-Chlorophenylalanine | H-DL-PHE(4-CL)-OH | DL-4-Chlorophenylalanine | DL-PCPA | p-chlorophenylalanine | 4-Chloro-DL-phenylalanine | 2-Amino-3-(4-chlorophen
规格或纯度 Moligand™, ≥98%
英文名称 4-Chloro-DL-phenylalanine
生化机理 4-氯-DL-苯丙氨酸（PCPA）是5-羟色胺（5-HT）合成抑制剂。有助于改善肺部组织炎症和重塑肺动脉。PCPA 可减少色氨酸羟化酶1（TPH1）、基质金属蛋白酶（MMP）和促炎因子的表达。 色氨酸羟化酶抑制剂。
运输条件 常规运输
作用类型 抑制剂
作用机制 左旋苯丙氨酸羟化酶抑制剂；左旋色氨酸羟化酶 1 抑制剂；左旋色氨酸羟化酶 2 抑制剂
产品介绍

用途

4-氯-DL-苯丙氨酸用于：

作为色氨酸羟化酶1（TPH1）抑制剂，处理 kras+ 雄性斑马鱼

在大鼠模型中诱发失眠

处理胚胎，检查其对5-羟色胺的影响

选择带 pESentA32质粒的粪肠球菌（ Enterococcus faecalis ）转化体

饲喂苍蝇，研究5-羟色胺的作用

Application

4-Chloro-DL-phenylalanine has been used:

as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish

to induce insomnia in rat models

used to treat embryos to examine its effect on serotonin

for the selection of Enterococcus faecalis transformants with pESentA32 plasmid

to feed flies to explore serotonin effect
纯度 ≥98%

关联靶点（人）

TPH1 Tclin 色氨酸5-羟化酶1(Tryptophan 5-hydroxylase 1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
TPH2 Tchem 色氨酸5-羟化酶2(Tryptophan 5-hydroxylase 2) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PAH Tclin 苯丙氨酸-4-羟化酶(Phenylalanine-4-hydroxylase) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
nfo Endonuclease 4 (425 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488179843
分子类型 小分子
IIUPAC Name 2-amino-3-(4-chlorophenyl)propanoic acid
INCHI 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
InChi Key NIGWMJHCCYYCSF-UHFFFAOYSA-N
Smiles C1=CC(=CC=C1CC(C(=O)O)N)Cl
Isomeric SMILES C1=CC(=CC=C1CC(C(=O)O)N)Cl
分子量 199.63
Beilstein号 14(1)608
Reaxy-Rn 2805758
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2805758&ln=

化学和物理性质

溶解性 Soluble to 10 mM in 1eq. NaOH and to 5 mM in water with gentle warming.
熔点 >240°C
分子量 199.630 g/mol
XLogP3 -0.500
氢键供体数Hydrogen Bond Donor Count 2
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 3
精确质量Exact Mass 199.04 Da
单同位素质量Monoisotopic Mass 199.04 Da
拓扑极表面积Topological Polar Surface Area 63.300 Ų
重原子数Heavy Atom Count 13
形式电荷Formal Charge 0
复杂度Complexity 178.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 1
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS06,   GHS07
信号词 危险
RTECS AY4390010

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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批号(Lot Number) 证书类型 货号
H2513319 分析证书 C136727
H2513320 分析证书 C136727
H2520705 分析证书 C136727
K2415467 分析证书 C136727
J2431175 分析证书 C136727
K2429001 分析证书 C136727
F2504160 分析证书 C136727
K2420087 分析证书 C136727
K2420088 分析证书 C136727
L2210442 分析证书 C136727
L2210444 分析证书 C136727
L2210445 分析证书 C136727
L2210447 分析证书 C136727
L2210458 分析证书 C136727
D2403358 分析证书 C136727
D2403170 分析证书 C136727
J2114474 分析证书 C136727
J2114483 分析证书 C136727
E2114320 分析证书 C136727
A2310494 分析证书 C136727
H2416042 分析证书 C136727
L2210441 分析证书 C136727
L2210443 分析证书 C136727
L2210446 分析证书 C136727
E2416078 分析证书 C136727
H2416057 分析证书 C136727
A2316024 分析证书 C136727
F2208249 分析证书 C136727
I2308032 分析证书 C136727
J2326089 分析证书 C136727
F2208250 分析证书 C136727
F2208252 分析证书 C136727
C2208165 分析证书 C136727
C2208166 分析证书 C136727
C2208167 分析证书 C136727
D2303626 分析证书 C136727

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此产品的引用文献

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引用文献

1. Koyuncuoğlu H, Eroğlu L, Güngör M.  (1975)  The effects of DL-p-chlorophenylalanine and DL-alpha-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat..  Psychopharmacologia,  45  (2): (163-6).  [PMID:129787]
2. Datla KP, Curzon G.  (1996)  Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats..  Neuropharmacology,  35  (3): (315-20).  [PMID:8783206]
3. Yu Yang, Zhe Chen, Guangli Yan, Ling Kong, Le Yang, Hui Sun, Ying Han, Jie Zhang, Xijun Wang.  (2023)  Mass spectrum oriented metabolomics for evaluating the efficacy and discovering the metabolic mechanism of Naoling Pian for insomnia.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  236  (115756).  [PMID:37776625] [10.1016/j.jpba.2023.115756]
4. Sun Runbin, Jin Dandan, Fei Fei, Xu Zhi, Cao Bei, Li Juan.  (2023)  Mushroom polysaccharides from Grifola frondosa (Dicks.) Gray and Inonotus obliquus (Fr.) Pilat ameliorated dextran sulfate sodium-induced colitis in mice by global modulation of systemic metabolism and the gut microbiota.  Frontiers in Pharmacology,  14  [PMID:37351508] [10.3389/fphar.2023.1172963]
5. Yinfang Lai, Liping Hua, Jiali Yang, Juewen Xu, Junduo Chen, Shuangshuang Zhang, Shunyao Zhu, Jingjing Li, Senlin Shi.  (2023)  The Effect of Chinese Agarwood Essential Oil with Cyclodextrin Inclusion against PCPA-Induced Insomnia Rats.  MOLECULES,  28  (2): (635).  [PMID:36677694] [10.3390/molecules28020635]
6. Peng Yu, Xu Zhang, Guohui Cheng, Haizhen Guo, Xiaoen Shi, Xinlu Zhang, Jun Zhou, Sheng Wang, Zhenggang Wu, Jin Chang.  (2022)  Construction of a new multifunctional insomnia drug delivery system.  CHEMICAL ENGINEERING JOURNAL,  430  (132633).  [10.1016/j.cej.2021.132633]
7. Zhengke Zhang, Jialiang Liu, Donald J. Huber, Hongxia Qu, Ze Yun, Taotao Li, Yueming Jiang.  (2021)  Transcriptome, degradome and physiological analysis provide new insights into the mechanism of inhibition of litchi fruit senescence by melatonin.  PLANT SCIENCE,  308  (110926).  [PMID:34034874] [10.1016/j.plantsci.2021.110926]
8. Cheng Hu, Ying Chen, Yiyuan Cao, Yiqun Jia, Jiaqi Zhang.  (2020)  Metabolomics analysis reveals the protective effect of quercetin-3-O-galactoside (Hyperoside) on liver injury in mice induced by acetaminophen.  JOURNAL OF FOOD BIOCHEMISTRY,  44  (10): (e13420).  [PMID:32744346] [10.1111/jfbc.13420]
9. Cheng Hu, Jiawen Ye, Licong Zhao, Xiulong Li, Yu Wang, Xinhua Liu, Lingyun Pan, Lisha You, Long Chen, Yiqun Jia, Jiaqi Zhang.  (2019)  5,7,3′,4′-flavan-on-ol (taxifolin) protects against acetaminophen-induced liver injury by regulating the glutathione pathway.  LIFE SCIENCES,  236  (116939).  [PMID:31593705] [10.1016/j.lfs.2019.116939]
10. Licong Zhao, Jiaqi Zhang, Lingyun Pan, Long Chen, Yu Wang, Xinhua Liu, Lisha You, Yiqun Jia, Cheng Hu.  (2019)  Protective effect of 7,3′,4′-flavon-3-ol (fisetin) on acetaminophen-induced hepatotoxicity in vitro and in vivo.  PHYTOMEDICINE,  58  (152865).  [PMID:30831465] [10.1016/j.phymed.2019.152865]
11. Zhu Jie, Zhang Hua-nan, Wu Jia-kai, Li Fei-fei, Liu Yu-qing, Ning Er-juan, Yu Li-qin, Liang Shen.  (2024)  A low n-6/n-3 PUFA ratio and high level of dietary ɑ-linolenic acid improves sleep behavior in mice with insomnia.  JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE,  (1-11).  [PMID:39431184] [10.1007/s13197-024-06004-1]
12. Zhang Qiang, Chen Wanyi, Qin Ming, Wang Yuhao, Pu Zhongji, Ding Keyan, Liu Yuyue, Zhang Qunfeng, Li Dongfang, Li Xinjia, Zhao Yu, Yao Jianhua, Huang Lei, Wu Jianping, Yang Lirong, Chen Huajun, Yu Haoran.  (2025)  Integrating protein language models and automatic biofoundry for enhanced protein evolution.  Nature Communications,  16  (1): (1-16).  [PMID:39934638] [10.1038/s41467-025-56751-8]
13. Weimin Hu, Ling Cheng, Jian Zhao, Yonghui Wu, Ying Lin, Jun Yin.  (2024)  Purine metabolite inosine induced by transforming growth factor‑β promotes epithelial‑mesenchymal transition in colorectal cancer.  Oncology Letters,  28  (3): (1-11).  [PMID:38988443] [10.3892/ol.2024.14549]
14. Xiaoyue Li, Yanai Chen, Huiyan Shao, Zheng Yan, Yun Wang, Shenzhou Lu.  (2025)  Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  301  (140500).  [PMID:39892546] [10.1016/j.ijbiomac.2025.140500]
15. Chang Zhou, Yi-fan Hu, Yan Zhang, Cheng-hao Wang, Xue-jing Liao, Fa-feng Cheng, Yan-yan Jiang.  (2024)  Study on chemical characterization and sleep-improvement function of Prunella vulgaris L. based on the functional components.  FOOD RESEARCH INTERNATIONAL,  192  (114737).  [PMID:39147482] [10.1016/j.foodres.2024.114737]

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