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甘珀酸 二钠盐

间隙连接阻滞剂，也是11β-羟类固醇脱氢酶的抑制剂
COA COA
    级别和纯度:
  • ≥98%
有货

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
C134840-1g
 1g 现货 Stock Image
C134840-5g
 5g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
11β-HSD (19) Anti-infection (2804) Cytoskeleton (497) Gap Junction Protein (15) Metabolic Enzyme/Protease (4889) Orthopoxvirus (58) Virus (3767) 脂质代谢 (4331)
main product photo

基本描述

英文别名 UNII-F1MP7242Z5 | CARBENOXOLONE SODIUM | CARBENOXOLONE SODIUM [WHO-DD] | Prestwick_19 | OLEAN-12-EN-29-OIC ACID, 3-(3-CARBOXY-1-OXOPROPOXY)-11-OXO, DISODIUM SALT, (3.BETA.,20.BETA.)- | Bioplex | Carbenoxolone, disodium salt | Berkobiogastrone | Carbenoxol
规格或纯度 ≥98%
英文名称 Carbenoxolone Disodium
生化机理 糖皮质激素抑制11β-羟基类固醇脱氢酶（11-HSD）并阻断间隙连接通讯。
储存温度 2-8°C储存
运输条件 冰袋运输
产品介绍

Carbenoxolone disodium 是甘草酸 (HY-N0184) 的活性代谢物和人 11β-HSD 和细菌 3α, 20β-HSD 的抑制剂。Carbenoxolone disodium 是一种缝隙连接的解耦剂 (gap junctions) 和并且可以有效抑制牛痘病毒生长。Carbenoxolone disodium 可用于研究消化性、食道和口腔溃疡和炎症的相关研究。

application：

Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 β-hydroxysteroid dehydrogenase (human) and 3α, 20 β-hydroxysteroid dehydrogenase (bacterial). It is used for the treatment of digestive tract ulcers, especially in the stomach. Used in the treatment of peptic, mainly gastric, ulcers. It is often used as a gap junction inhibitor in neuroscience research.
纯度 ≥98%

关联靶点（人）

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504759612
分子类型 小分子
IIUPAC Name disodium;(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-(3-carboxylatopropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate
INCHI 1S/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/q;2*+1/p-2/t21-,23-,24-,27+,30+,31-,32-,33+,34+;;/m0../s1
InChi Key BQENDLAVTKRQMS-SBBGFIFASA-L
Smiles CC1(C2CCC3(C(C2(CCC1OC(=O)CCC(=O)[O-])C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)[O-])C)C)C)C.[Na+].[Na+]
Isomeric SMILES C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)CCC(=O)[O-])C)(C)C(=O)[O-].[Na+].[Na+]
PubChem CID 636402
分子量 614.72

化学和物理性质

溶解性 溶于water, 最高浓度 (mg/mL): 61.47, 最高浓度(mM): 100
敏感性 对湿度敏感
分子量 614.700 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 7
可旋转键计数Rotatable Bond Count 4
精确质量Exact Mass 614.32 Da
单同位素质量Monoisotopic Mass 614.32 Da
拓扑极表面积Topological Polar Surface Area 124.000 Ų
重原子数Heavy Atom Count 43
形式电荷Formal Charge 0
复杂度Complexity 1190.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 9
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 3

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H319: 引起严重眼睛刺激
预防措施声明

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
WGK Germany 3
RTECS RK0250000
个人防护装备 dust mask type N95 (US)， Eyeshields， Gloves

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C of A & Other Certificates(BSE/TSE, COO):
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找到2个结果

批号(Lot Number) 证书类型 货号
J2217228 分析证书 C134840
J2217292 分析证书 C134840

引用文献

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