计算溶液所需的质量、体积或浓度。
This is a demo store. No orders will be fulfilled.
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C129108-1g |
1g |
现货 ![]() |
| |
| C129108-5g |
5g |
现货 ![]() |
| |
| C129108-25g |
25g |
现货 ![]() |
| |
| C129108-100g |
100g |
现货 ![]() |
| |
| C129108-500g |
500g |
现货 ![]() |
|
| 别名 | 卡托普利 | 巯甲丙脯酸 | (S)-1-(3-巯基-2-甲基-1-氧代丙基)-L-脯氨酸 | S)-(-)-1-(3-巯基-2-甲基丙酰基)-L-脯氨酸 |
|---|---|
| 英文别名 | Acepress | Captopril [USAN:USP:INN:BAN:JAN] | 1-((2S)-2-Methyl-3-sulfanylpropanoyl)-L-proline # | CHEBI:3380 | DTXSID1037197 | DTXCID9017197 | Tensoprel | Captopril,(S) | Captoprilum [INN-Latin] | Zapto | Tenosbon | 1-(3-Mercapto-2-methyl-1-oxopropyl)-L-p |
| 规格或纯度 | Moligand™, ≥98% |
| 英文名称 | Captopril |
| 生化机理 | 血管紧张素转换酶抑制剂。抑制血管紧张素 II 的形成,血管紧张素 II 是生物活性多肽,可促进血管生成并增加微血管密度。有效的ACE抑制剂(IC 50 = 21 nM)。可逆和竞争性白三烯A 4水解酶抑制剂(K i = 6μM,白三烯B4形成)。体内血管舒张和抗高血压作用。口服具有活性 |
| 应用 | Captopril是一种血管紧张素转换酶(ACE)抑制剂,IC50为6 nM。 |
| 储存温度 | -20°C储存,充氩 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 血管紧张素转换酶抑制剂 |
| 备注 | 不稳定 重新制作解决方案并立即使用。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
| 产品介绍 |
Captopril is a reversible and competitive inhibitor of leukotriene A4 hydrolase (LTA4H; IC50 = 11μM). Captopril has been shown to be an inhibitor of angiotensin converting enzyme-1 (ACE1), but not ACE2 (IC50 = 22 nM). Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity. Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.Captopril是一种血管紧张素转换酶(ACE)抑制剂,IC50为6 nM。 Captopril is a reversible and competitive inhibitor of leukotriene A4 hydrolase (LTA4H; IC50 = 11μM). Captopril has been shown to be an inhibitor of angiotensin converting enzyme-1 (ACE1), but not ACE2 (IC50 = 22 nM). Captopril demonstrates noncompetitive inhibition of tyrosinase monophenolase activity and competitive inhibition of diphenolase activity. Captopril has also been shown to inhibit the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density. |
| 纯度 | ≥98% |
| ALogP | 0.3 |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504753631 |
|---|---|
| EC号 | 263-607-1 |
| 分子类型 | 小分子 |
| IIUPAC Name | (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid |
| INCHI | 1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1 |
| InChi Key | FAKRSMQSSFJEIM-RQJHMYQMSA-N |
| Smiles | CC(CS)C(=O)N1CCCC1C(=O)O |
| Isomeric SMILES | C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O |
| 分子量 | 217.29 |
| Beilstein号 | 477887 |
| Reaxy-Rn | 3651421 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3651421&ln= |
| 溶解性 | Soluble in water (160 mg/ml) at 25 °C, sesame and corn oils (100 mg/ml), ethanol (>100 mg/ml), isopropanol (>100 mg/ml), chloroform (>100 mg/ml), and dichloromethane (>100 mg/ml). |
|---|---|
| 敏感性 | 对空气敏感 |
| 比旋光度 | -127.5° |
| 熔点 | 106°C |
| 分子量 | 217.290 g/mol |
| XLogP3 | 0.300 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 217.077 Da |
| 单同位素质量Monoisotopic Mass | 217.077 Da |
| 拓扑极表面积Topological Polar Surface Area | 58.600 Ų |
| 重原子数Heavy Atom Count | 14 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 244.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 2 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS05, GHS07, GHS08 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H317: 可能引起皮肤过敏反应 H318: 造成严重的眼睛损伤 H360: 可能损害生育力或未出生的孩子 H361: 怀疑破坏生育力或未出生的孩子 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P272: 被污染的工作服不允许离开工作场所 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理(请参阅此标签上的...)。 P302+P352: 如皮肤沾染:用水充分清洗。 P333+P313: 如发生皮肤刺激或皮疹:求医/就诊。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P203: 使用前,获取、阅读并遵守所有安全说明。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P305+P354+P338: 如果进入眼睛:立即用水冲洗几分钟。取下隐形眼镜(如果有的话),并且操作简单。继续冲洗。 P318: 如果暴露或担心,请就医。 P317: 寻求紧急医疗救助。 |
| WGK Germany | 3 |
| RTECS | UY0550000 |
| Merck Index | 1774 |
| 个人防护装备 | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 | |
| 分析证书 | C129108 |
| 1. Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo. (2024) Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 126 (105825). [10.1016/j.jfca.2023.105825] |
| 2. Yanan Guan, Yueyue Zu, Pengyi Ma, Shutao Li, Qi Ma, Jinping Song, Yong Guo. (2023) Cascade Fluorescent Determination of Mercury (II) and Captopril Using Tungsten-Nitrogen Doped Carbon Dots. ANALYTICAL LETTERS, [10.1080/00032719.2023.2180802] |
| 3. Xu Tao, Ji Haifeng, Xu Lin, Cheng Shengjun, Liu Xianda, Li Yupei, Zhong Rui, Zhao Weifeng, Kizhakkedathu Jayachandran N., Zhao Changsheng. (2023) Self-anticoagulant sponge for whole blood auto-transfusion and its mechanism of coagulation factor inactivation. Nature Communications, 14 (1): (1-20). [PMID:37573353] [10.1038/s41467-023-40646-7] |
| 4. Jing Zhu, Lei Hu, Xiangying Meng, Feng Li, Wenjuan Wang, Guiyang Shi, Zhongxia Wang. (2023) Synergism of Photo-Induced Electron Transfer and Aggregation-Induced Quenching Mechanisms for Highly Sensitive Detection of Silver Ion and Captopril. MOLECULES, 28 (9): (3650). [PMID:37175061] [10.3390/molecules28093650] |
| 5. Xuwen Gao, Xiancheng Liu, Ying Zeng, Qingqing Zhang, Bin Zhang, Guizheng Zou. (2022) Spectrum-Resolved Electrochemiluminescence to Multiplex the Immunoassay and DNA Probe Assay. ANALYTICAL CHEMISTRY, 94 (45): (15801–15808). [PMID:36334096] [10.1021/acs.analchem.2c03579] |
| 6. Kun Liu, Xiaohan Zhang, Xiongfeng Zhou, Xinming Huo, Xiaohao Wang, Kostya (Ken) Ostrikov. (2022) Experimental investigation of an atmospheric pressure plasma jet as an ion source for on-site mass-spectrometry analysis of nonvolatile solid samples: the integration effect of thermal desorption and ionization. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 55 (48): (485202). [10.1088/1361-6463/ac968a] |
| 7. Wang Yiran, Shi Jihua, Dai Dapeng, Cai Jianping, Wang Shuanghu, Hong Yun, Zhou Shan, Zhao Fangling, Zhou Quan, Geng Peiwu, Zhou Yunfang, Xu Xue, Luo Qingfeng. (2022) Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo. Frontiers in Pharmacology, 13 [PMID:36052128] [10.3389/fphar.2022.909168] |
| 8. Lixia Han, Ting Liu, Di Cui, Jiaqi Yi, Wei Jiang, Xiaoshuang Li, Na Niu, Ligang Chen. (2022) Quantitative detection of captopril in urine by smartphone-assisted ratiometric fluorescence sensing platform. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 280 (121562). [PMID:35780761] [10.1016/j.saa.2022.121562] |
| 9. Shuangtian Dong, Dongyang Wang, Xuwen Gao, Li Fu, Jingna Jia, Yuqi Xu, Bin Zhang, Guizheng Zou. (2022) Glow and Flash Adjustable Chemiluminescence with Tunable Waveband from the Same CuInS2@ZnS Nanocrystal Luminophore. ANALYTICAL CHEMISTRY, 94 (18): (6902–6908). [PMID:35486816] [10.1021/acs.analchem.2c01083] |
| 10. Cheng-Yuan Dong, Sheng Hong, Di-Wei Zheng, Qian-Xiao Huang, Fu-Sheng Liu, Zhen-Lin Zhong, Xian-Zheng Zhang. (2020) Multifunctionalized Gold Sub-Nanometer Particles for Sensitizing Radiotherapy against Glioblastoma. Small, 17 (5): (2006582). [PMID:33382206] [10.1002/smll.202006582] |
| 11. Zhong-Xia Wang, Xing Jin, Wen-Juan Wang, Fen-Ying Kong, Jing Zhu, Heng-Ye Li, Yu-Jie Ding, Wei Wang. (2021) Green synthesis of a deep-ultraviolet carbonized nanoprobe for ratiometric fluorescent detection of feroxacin and enrofloxacin in food and serum samples. ANALYST, 146 (3): (874-881). [PMID:33241796] [10.1039/D0AN02114H] |
| 12. Haiyan Cao, Mingjie Tang, Xin Wang, Wenbing Shi. (2020) Facile and rapid synthesis of emission color-tunable molybdenum oxide quantum dots as a versatile probe for fluorescence imaging and environmental monitoring. ANALYST, 145 (19): (6270-6276). [PMID:32936129] [10.1039/D0AN01510E] |
| 13. Yang Xu, Jin Li, Jian Zhou, Yufeng Liu, Zhuojun Wei, Hui Zhang. (2020) Layered double hydroxides supported atomically precise Aun nanoclusters for air oxidation of benzyl alcohol: Effects of size and active site structure. JOURNAL OF CATALYSIS, 389 (409). [10.1016/j.jcat.2020.06.017] |
| 14. Tian Ruochen, Suo Hao, Zhang Shuting, Sun Baoshan. (2020) Separation of a family of antioxidants flavan-3-ol thio-conjugates from procyanidins by high-speed counter-current chromatography. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 246 (5): (1017-1029). [10.1007/s00217-020-03465-4] |
| 15. Zhang Pu, Wang Li, Zeng Jing, Tan Juan, Long Yunfei, Wang Yi. (2020) Colorimetric captopril assay based on oxidative etching-directed morphology control of silver nanoprisms. MICROCHIMICA ACTA, 187 (2): (1-8). [PMID:31915936] [10.1007/s00604-019-4071-8] |
| 16. Shi Yi, Peng Jun, Meng Xiaoyan, Huang Tao, Zhang Jingyi, He Hua. (2018) Turn-on fluorescent detection of captopril in urine samples based on hydrophilic hydroxypropyl β-cyclodextrin polymer. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (28): (7373-7384). [PMID:30191274] [10.1007/s00216-018-1343-9] |
| 17. Wang Zhong-Xia, Gao Yuan-Fei, Yu Xian-He, Kong Fen-Ying, Lv Wei-Xin, Wang Wei. (2018) Photoluminescent coral-like carbon-branched polymers as nanoprobe for fluorometric determination of captopril. MICROCHIMICA ACTA, 185 (9): (1-9). [PMID:30128634] [10.1007/s00604-018-2961-9] |
| 18. YingHui Zhang, Bing Wang, Feng Guo, ZhiZhen Li, GuiJun Qin. (2018) Involvement of the TGFβ1- ILK-Akt signaling pathway in the effects of hesperidin in type 2 diabetic nephropathy. BIOMEDICINE & PHARMACOTHERAPY, 105 (766). [PMID:29909344] [10.1016/j.biopha.2018.06.036] |