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L-瓜氨酸, GPRC6 受体激动剂

非必需α-氨基酸。精氨酸琥珀酸酯合酶底物。
32篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
C109228-5g
 5g 现货 Stock Image
C109228-25g
 25g 现货 Stock Image
C109228-100g
 100g 现货 Stock Image
C109228-500g
 500g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
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GPRC6 receptor Agonist (9) 代谢物 (8911)
main product photo

基本描述

别名 L-瓜氨酸 | 脲氨基戊酸
英文别名 N(5)-carbamoyl-L-ornithine | N~5~-carbamoyl-L-ornithine | Ornithine, N5-(aminocarbonyl)- | bmse000032 | L-N5-carbamoyl-Ornithine | N(SUP 5)-(AMINOCARBONYL)-L-ORNITHINE | N5-(Aminocarbonyl)-L-ornithine | HY-N0391 | C6H13N3O3 | L-Citruline | Ureidovalerate
规格或纯度 Moligand™, ≥97%
英文名称 L-Citrulline
生化机理 口服L-瓜氨酸可改善人类镰状细胞疾病的状况。在NO（一氧化氮）合成酶缺陷的情况下，可以服用L-瓜氨酸，替代L-精氨酸。人们发现L-瓜氨酸补充剂能满足NO（一氧化氮）依赖型信号传导的目的。通过NO（一氧化氮）合成酶，从L-精氨酸生产一氧化氮的中间体。非必需α-氨基酸。精氨酸琥珀酸酯合酶底物。精氨酸琥珀酸酯合酶底物。从L-精氨酸生物合成一氧化氮的必要中间体。口服具有活性
应用 L-瓜氨酸已用于超高效液相色谱中，以验证参与变质过程协调的代谢物。
运输条件 常规运输
作用类型 激动剂
作用机制 GPRC6 受体激动剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

L-Citrulline is an essential intermediate in biosynthesis of nitric oxide from L-arginine.An essential intermediate in the biosynthesis of nitric oxide.

L-Citrulline is an essential intermediate in biosynthesis of nitric oxide from L-arginine.
An essential intermediate in the biosynthesis of nitric oxide.
纯度 ≥97%

关联靶点（人）

GPRC6A Tchem G 蛋白偶联受体家族 C 组 6 成员 A(G-protein coupled receptor family C group 6 member A) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GAP1 General amino-acid permease GAP1 (481 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488181022
EC号 206-759-6
分子类型 小分子
IIUPAC Name (2S)-2-amino-5-(carbamoylamino)pentanoic acid
INCHI 1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1
InChi Key RHGKLRLOHDJJDR-BYPYZUCNSA-N
Smiles C(CC(C(=O)O)N)CNC(=O)N
Isomeric SMILES C(C[C@@H](C(=O)O)N)CNC(=O)N
分子量 175.19
Beilstein号 1725416
Reaxy-Rn 1725417
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1725417&ln=

化学和物理性质

溶解性 Soluble in water (200 mg/ml at 20 °C), and 1M HCl.
密度 1.289
比旋光度 26 ° (C=8, 6mol/L HCl)
熔点 214-216°C
分子量 175.190 g/mol
XLogP3 -4.300
氢键供体数Hydrogen Bond Donor Count 4
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 5
精确质量Exact Mass 175.096 Da
单同位素质量Monoisotopic Mass 175.096 Da
拓扑极表面积Topological Polar Surface Area 118.000 Ų
重原子数Heavy Atom Count 12
形式电荷Formal Charge 0
复杂度Complexity 171.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 1
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激
预防措施声明

P264: 处理后要彻底洗手。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P302+P352: 如皮肤沾染：用水充分清洗。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
WGK Germany 3
Merck Index 2331
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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找到22个结果

批号(Lot Number) 证书类型 货号
H2522248 分析证书 C109228
H2522366 分析证书 C109228
H2522436 分析证书 C109228
H2522437 分析证书 C109228
I2425230 分析证书 C109228
I2425227 分析证书 C109228
I2425228 分析证书 C109228
I2425229 分析证书 C109228
G2403201 分析证书 C109228
G2403243 分析证书 C109228
H2412487 分析证书 C109228
F2216275 分析证书 C109228
F2216292 分析证书 C109228
F2216293 分析证书 C109228
F2216294 分析证书 C109228
B2310248 分析证书 C109228
C23211000 分析证书 C109228
C23211004 分析证书 C109228
K2309014 分析证书 C109228
L2314041 分析证书 C109228
H2408046 分析证书 C109228
D1820086 分析证书 C109228

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引用文献

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27. Tyler A Churchward-Venne,Lisa M Cotie,Maureen J MacDonald,Cameron J Mitchell,Todd Prior,Steven K Baker,Stuart M Phillips.  (2014-05-16)  Citrulline does not enhance blood flow, microvascular circulation, or myofibrillar protein synthesis in elderly men at rest or following exercise..  American journal of physiology. Endocrinology and metabolism,  307  ((1)): (E71-E83).  [PMID:24824653]
28. Jace W Jones,Gregory Tudor,Alexander Bennett,Ann M Farese,Maria Moroni,Catherine Booth,Thomas J MacVittie,Maureen A Kane.  (2014-05-21)  Development and validation of a LC-MS/MS assay for quantitation of plasma citrulline for application to animal models of the acute radiation syndrome across multiple species..  Analytical and bioanalytical chemistry,  406  ((19)): (4663-4675).  [PMID:24842404]
29. Anke Böhmer,Stepan Gambaryan,Markus Flentje,Jens Jordan,Dimitrios Tsikas.  (2014-07-18)  [Ureido-¹⁵N]citrulline UPLC-MS/MS nitric oxide synthase (NOS) activity assay: development, validation, and applications to assess NOS uncoupling and human platelets NOS activity..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  965  (173-182).  [PMID:25033468]
30. Mirelle J A J Huijskens,Mateusz Walczak,Nicole Koller,Jacob J Briedé,Birgit L M G Senden-Gijsbers,Melanie C Schnijderberg,Gerard M J Bos,Wilfred T V Germeraad.  (2014-08-27)  Technical advance: ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells..  Journal of leukocyte biology,  96  ((6)): (1165-1175).  [PMID:25157026]
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