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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C102139-25mg |
25mg |
现货 ![]() |
| |
| C102139-250mg |
250mg |
现货 ![]() |
| |
| C102139-1g |
1g |
现货 ![]() |
| |
| C102139-5g |
5g |
现货 ![]() |
| |
| C102139-25g |
25g |
现货 ![]() |
| |
| C102139-100g |
100g |
现货 ![]() |
|
| 别名 | 3,4-二羟基肉桂酸苯乙酯 |
|---|---|
| 英文别名 | Caffeic acid phenethyl ester, >=97% (HPLC), powder | LS-14562 | Methanone, 1,1'-(1,2-cyclopropanediyl)bis[1-phenyl- | SR-01000075785-1 | SR-01000075785-6 | HMS3677D22 | Lopac0_000269 | EU-0100269 | HMS1791N22 | NCGC00093727-08 | NCGC00093727-16 | phenethy |
| 规格或纯度 | ≥97% |
| 英文名称 | Caffeic acid phenethyl ester |
| 生化机理 | 咖啡酸苯乙酯是核转录因子 NF-κ B的特异性抑制剂。蛋白酪氨酸激酶和鸟氨酸脱羧酶抑制剂。咖啡酸衍生物。抑制5-脂氧合酶。诱导细胞凋亡。调节细胞氧化还原状态。抑制MDI诱导的脂肪生成。显示抗肥胖和消炎 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
| 产品介绍 |
Caffeic acid phenethyl ester (CAPE) is the active component of propolis, a honeybee hive product. Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor, NF-κB.CAPE has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. Caffeic acid phenethyl ester inhibits HIV-1 integrase, and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity. |
| 纯度 | ≥97% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504763386 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 2-phenylethyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate |
| INCHI | 1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+ |
| InChi Key | SWUARLUWKZWEBQ-VQHVLOKHSA-N |
| Smiles | C1=CC=C(C=C1)CCOC(=O)C=CC2=CC(=C(C=C2)O)O |
| Isomeric SMILES | C1=CC=C(C=C1)CCOC(=O)/C=C/C2=CC(=C(C=C2)O)O |
| 分子量 | 284.31 |
| Reaxy-Rn | 6603186 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6603186&ln= |
| 溶解性 | Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol. |
|---|---|
| 密度 | 1.266 |
| 敏感性 | 对热敏感&对光线敏感 |
| 熔点 | 127-131℃ |
| 分子量 | 284.310 g/mol |
| XLogP3 | 4.200 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 284.105 Da |
| 单同位素质量Monoisotopic Mass | 284.105 Da |
| 拓扑极表面积Topological Polar Surface Area | 66.800 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 347.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理(请参阅此标签上的...)。 P302+P352: 如皮肤沾染:用水充分清洗。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续:寻求医疗帮助。 P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。 P319: 如果你感到不适,请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | UD3334375 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 | |
| 分析证书 | C102139 |
| 1. Zi-Chen Jia, Duo Liu, Hai-Di Ma, Yu-Hui Cui, Hui-Min Li, Xia Li, Ying-Jin Yuan. (2023) Yeast Metabolic Engineering for Biosynthesis of Caffeic Acid-Derived Phenethyl Ester and Phenethyl Amide. ACS Synthetic Biology, [PMID:38016187] [10.1021/acssynbio.3c00413] |
| 2. Chengjun Peng, Guichun Wang, Yuxiao Wang, Maomao Tang, Xiaodong Ma, Xiangwei Chang, Jian Guo, Shuangying Gui. (2022) Thermosensitive acetylated carboxymethyl chitosan gel depot systems sustained release caffeic acid phenethyl ester for periodontitis treatment. POLYMERS FOR ADVANCED TECHNOLOGIES, 34 (1): (155-165). [10.1002/pat.5874] |
| 3. Weichao Sun, Wei Xie, Dixi Huang, Yinxing Cui, Jiaji Yue, Qifei He, Luoyong Jiang, Jianyi Xiong, Wei Sun, Qian Yi. (2022) Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 50 (5): (1-14). [PMID:36102306] [10.3892/ijmm.2022.5190] |
| 4. Cui Zhanding, Wang Qian, Li Dengliang, Zhao Shihui, Zhang Qian, Tan Yuxin, Gong Qianwen, Liu Ting, Shao Jiang, Zhang Shuang, Huang Hailong, Wang Junzheng, Pei Zhihua, Dong Hao, Wang Kai, Hu Guixue, Li Zhiyong. (2021) Icariin, Formononetin and Caffeic Acid Phenethyl Ester Inhibit Feline Calicivirus Replication In Vitro. ARCHIVES OF VIROLOGY, 166 (9): (2443-2450). [PMID:34173062] [10.1007/s00705-021-05107-w] |
| 5. Fengjie Yu, Jianing Zhang, Yunmin Tao, Chunping Du, Wenchao Yang, Wenbin Chen, Xijuan Tu. (2021) High-throughput subzero-temperature assisted homogenous liquid-liquid extraction for the fast sample preparation of multiple phenolic compounds in propolis. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1179 (122823). [PMID:34147873] [10.1016/j.jchromb.2021.122823] |
| 6. Beibei Zhang, Liping Zhuang, Duanping Sun, Yinbao Li, Zuanguang Chen. (2020) An integrated microfluidics for assessing the anti-aging effect of caffeic acid phenethylester in Caenorhabditis elegans. ELECTROPHORESIS, 42 (6): (742-748). [PMID:33184875] [10.1002/elps.202000251] |
| 7. Rili Hao, Xinyu Song, Feng Li, Xintong Tan, Dongxiao Sun-Waterhouse, Dapeng Li. (2020) Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK/SIRT1 pathway and amyloid-tau-neuroinflammation axis. FOOD AND CHEMICAL TOXICOLOGY, 144 (111636). [PMID:32739455] [10.1016/j.fct.2020.111636] |
| 8. Rili Hao, Feng Li, Xinyu Song, Xintong Tan, Dongxiao Sun-Waterhouse, Dapeng Li. (2020) Caffeic acid phenethyl ester against cadmium induced toxicity mediated by CircRNA modulates autophagy in HepG2 cells. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 197 (110610). [PMID:32298858] [10.1016/j.ecoenv.2020.110610] |
| 9. Wenbin Chen, Xijuan Tu, Dehui Wu, Zhaosheng Gao, Siyuan Wu, Shaokang Huang. (2019) Comparison of the Partition Efficiencies of Multiple Phenolic Compounds Contained in Propolis in Different Modes of Acetonitrile–Water-Based Homogenous Liquid–Liquid Extraction. MOLECULES, 24 (3): (442). [PMID:30691151] [10.3390/molecules24030442] |
| 10. Lingmei Sun, Kai Liao, Chengcheng Hang. (2018) Caffeic acid phenethyl ester synergistically enhances the antifungal activity of fluconazole against resistant Candida albicans. PHYTOMEDICINE, 40 (55). [PMID:29496175] [10.1016/j.phymed.2017.12.033] |
| 11. Yang Hongli, Huang Zhongping, Chen Yin, Zhang Changjun, Ye Mengdie, Wang Lili. (2016) Evaluation of the contributions of polyphenols in Chinese propolis by on-line HPLC–ABTS method. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 242 (4): (537-546). [10.1007/s00217-015-2564-1] |
| 12. Xinyue Wang, Siyi Feng, Hongdong Song. (2024) Caffeic Acid Phenethyl Ester Encapsulated in Self-Assemble Rice Peptides Nanoparticles: Storage Stability, In Vitro Release, and Their Interaction Mechanisms. Foods, 13 (5): (755). [PMID:38472867] [10.3390/foods13050755] |
| 13. Yuxiao Wang, Guichun Wang, Jiaxin Li, Maomao Tang, Baoqing Jia, Zixuan Shu, Yang Ding, Chengjun Peng, Shuangying Gui, Jian Guo. (2024) CCL2-scavenging nanodecoy hydrogel multi-step remodel monocytes recruitment and macrophages polarization for periodontitis treatment. CHEMICAL ENGINEERING JOURNAL, (157660). [10.1016/j.cej.2024.157660] |
| 14. Hongdong Song, Shaoxia Ren, Xinyue Wang, Yawen Hu, Mingda Xu, Hang Zhang, Hongwei Cao, Kai Huang, Chengtao Wang, Xiao Guan. (2024) Encapsulation of caffeic acid phenethyl ester by self-assembled sorghum peptide nanoparticles: Fabrication, storage stability and interaction mechanisms. FOOD CHEMISTRY, 453 (139642). [PMID:38788643] [10.1016/j.foodchem.2024.139642] |
| 15. Liu Xin, Li Jiale, Liu Shuyu, Long Yan, Kang Ching, Zhao Chen, Wei Ling, Huang Shaoqi, Luo Yi, Dai Bo, Zhu Xiangjia. (2024) Fabrication of a 3D bioprinting model for posterior capsule opacification using GelMA and PLMA hydrogel-coated resin. Regenerative Biomaterials, [PMID:38529352] [10.1093/rb/rbae020] |
| 16. Mingyuan Gu, Hongwei Fu, Apparao M. Rao, Jiang Zhou, Yue lin, Shuangchun Wen, Ling Fan, Bingan Lu. (2024) In Situ Construction of Uniform and Elastic Solid–Electrolyte Interphase for High-Performance Potassium Batteries. ADVANCED FUNCTIONAL MATERIALS, 34 (46): (2407867). [10.1002/adfm.202407867] |
| 17. Chengjun Peng, Guichun Wang, Jiaxin Li, Yuxiao Wang, Zixuan Shu, Maomao Tang, Xiaodong Ma, Jian Guo, Shuangying Gui. (2024) Ros-responsive and scavenging bifunctional hydrogel enables co-delivery of anti-inflammatory agent and osteogenetic nanoparticle for periodontitis treatment. MATERIALS & DESIGN, 239 (112777). [10.1016/j.matdes.2024.112777] |
| 18. Mengqi Han, Qinfei Chen, Weikang Tang, Hong Zhou, Jiadong Chen, Wenbin Liu. (2024) Sustainable production of multifunctional melanin-like amino acid surfactant by conjugating o-quinone building block from natural polyphenols. Journal of Cleaner Production, 462 (142691). [10.1016/j.jclepro.2024.142691] |