| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C101550-5mg |
5mg |
期货  |
| |
| C101550-20mg |
20mg |
现货 |
|
| 别名 | 氯化黄连碱,黄连碱 |
|---|---|
| 英文别名 | 6,7-Dihydro-2H,10H-[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-5-ium chloride | Coptisine-chloride | Coptisine chloride, analytical standard | Q-100696 | 2-butanoyl-4-[(3-butanoyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-3,5-dihydrox |
| 规格或纯度 | 分析标准品, ≥98% |
| 英文名称 | Coptisine |
| 应用 | 抗菌。 氯化黄连碱, 黄连碱, 6020-18-4 |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
极略微溶于水, 微溶于乙醇, 溶于碱。 |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 5,7,17,19-tetraoxa-13-azoniahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(13),2,4(8),9,14,16(20),21,23-octaene;chloride |
| INCHI | 1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1 |
| InChi Key | LUXPUVKJHVUJAV-UHFFFAOYSA-M |
| Smiles | C1C[N+]2=C(C=C3C=CC4=C(C3=C2)OCO4)C5=CC6=C(C=C51)OCO6.[Cl-] |
| Isomeric SMILES | C1C[N+]2=C(C=C3C=CC4=C(C3=C2)OCO4)C5=CC6=C(C=C51)OCO6.[Cl-] |
| 分子量 | 355.77 |
| Reaxy-Rn | 4118452 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4118452&ln= |
| 熔点 | 218°C |
|---|---|
| 分子量 | 355.800 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 355.061 Da |
| 单同位素质量Monoisotopic Mass | 355.061 Da |
| 拓扑极表面积Topological Polar Surface Area | 40.800 Ų |
| 重原子数Heavy Atom Count | 25 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 502.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
| 1. Jin Pian, Zhu Fucheng, Zhou Wen, Liu Chen, Li Na, Liu Houmei. (2023) Developing magnetic functionalized dendritic fibrous mesoporous silica as advanced adsorbent for quaternary ammonium alkaloids. MICROCHIMICA ACTA, 190 (12): (1-12). [PMID:37999777] [10.1007/s00604-023-06053-x] |
| 2. Yang Gao, Shi-Qiao Liu, Jia-Long Wang, Han-Ming Cui, Qiu-Yan Zhang, Lei Wang, Yi-Xin Zhang, Jian Li, Yu Dong, Yuan-Hui Hu. (2024) Vitro UPLC analysis and mass method identification, and in vivo or cellular immune anti-inflammatory function of Sanhuang Xiexin Decoction (SHXD). JOURNAL OF ETHNOPHARMACOLOGY, 318 (117002). [PMID:37544343] [10.1016/j.jep.2023.117002] |
| 3. Longlong Gao, Rui Tian, Yong Shao. (2023) Photocatalytic Duplex-Based DNAzymes Switched by an Abasic Site. Chemistry-Switzerland, 5 (3): (1497-1507). [10.3390/chemistry5030102] |
| 4. Jiajia Zhai, Zeping Li, Huifeng Zhang, Zuowei Lu, Yi Zhang, Mo Li, Jian Kang, Zelong Yang, Louyan Ma, Li Ma, Zhengquan Ma, Xiaorui Ma, Fanghong Zhao, Xiaoqing Ma, Yuan Gao, Yuanyuan Zhang, Xiaomiao Li. (2023) Coptisine mitigates diabetic nephropathy via repressing the NRLP3 inflammasome. Open Life Sciences, 18 (1): [PMID:37197172] [10.1515/biol-2022-0568] |
| 5. Huanyu Guan, Pengfei Li, Qian Wang, Fanli Zeng, Jiashuo Wu, Fangqing Zhang, Shanggao Liao, Yue Shi. (2022) Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultrahigh-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry and the impact of 20 characteristic components on multidrug resistance-associated protein 2 in the vesicular transport assay. JOURNAL OF SEPARATION SCIENCE, 45 (18): (3459-3479). [PMID:35838583] [10.1002/jssc.202200370] |
| 6. Yingxin Chen, Xiaotong Huang, Lu Li, Junxian Wu, Yongqi Guo, Yachao Yao, Lihua Zhou. (2022) Paper mill sludge-based carbon quantum dots as a specifically ratiometric fluorescent probe for the sensitive and selective detection of coptisine. LUMINESCENCE, 37 (7): (1078-1086). [PMID:35441456] [10.1002/bio.4260] |
| 7. Lu Shao Hua, Zhang Ming Cai, Zhai Hong Lin, Bi Ke Xin, Zhao Bing Qiang. (2022) Rapid Determination in the Quality Control of Chinese Patent Medicine. Journal of Pharmaceutical Innovation, 17 (4): (1305-1313). [10.1007/s12247-021-09608-8] |
| 8. Kun Yan, Lancheng Wang, Huimin Zhou, Zhendong Hua, Peng Xu, Hui Xu, Youmei Wang, Bin Di, Chi Hu. (2022) Cucurbituril-mediated AIE: An unconventional indicator displacement assay for ketamine detection. DYES AND PIGMENTS, 197 (109875). [10.1016/j.dyepig.2021.109875] |
| 9. Hanzhi Zhang, Chunli Lou, Jing Li, Jingwu Kang. (2020) A gold foil covered fused silica capillary tip as a sheathless interface for coupling capillary electrophoresis-mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1624 (461215). [PMID:32540065] [10.1016/j.chroma.2020.461215] |
| 10. Yuehua Hu, Fan Lin, Tao Wu, Ying Wang, Xiao-Shun Zhou, Yong Shao. (2016) Fluorescently Sensing of DNA Triplex Assembly Using an Isoquinoline Alkaloid as Selector, Stabilizer, Inducer, and Switch-On Emitter. Chemistry-An Asian Journal, 11 (14): (2041-2048). [PMID:27252050] [10.1002/asia.201600459] |
| 11. Ting Tan, Mingliang Zhang, Yiqun Wan, Hongdeng Qiu. (2016) Utilization of deep eutectic solvents as novel mobile phase additives for improving the separation of bioactive quaternary alkaloids. TALANTA, 149 (85). [PMID:26717817] [10.1016/j.talanta.2015.11.041] |
| 12. Wenpeng Zhang, Zilin Chen. (2013) Preparation of micropipette tip-based molecularly imprinted monolith for selective micro-solid phase extraction of berberine in plasma and urine samples. TALANTA, 103 (103). [PMID:23200364] [10.1016/j.talanta.2012.10.014] |
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