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D-生物素

60篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
B656921-100mg
 100mg 现货 Stock Image
B656921-500mg
 500mg 现货 Stock Image
B656921-1g
 1g 现货 Stock Image
B656921-5g
 5g 现货 Stock Image
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代谢物 (8911) 核苷 (19)
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基本描述

别名 维生素H | 辅酶R
英文别名 4bj8 | Acidum capobenicum [INN-Latin] | CHEBI:15956 | Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid, (3aS-(3aalpha,4beta,6aalpha))- | hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid | 2'-Keto-3,4-imidazolido-2-tetrahydrothiophene-N
规格或纯度 Moligand™, 无动物源, 用于细胞培养(培养基原料), ≥99%
英文名称 D-Biotin
储存温度 2-8°C储存
运输条件 冰袋运输
产品介绍

25°C溶解度:22 MG/100 ML 水 、80 MG/100 ML乙醇。较易溶于热水和稀碱液，不溶于其他常用有机溶剂。遇强碱或氧化剂则分解。

May be used to elute proteins from avidin/streptavidin resins.
纯度 ≥99%

关联靶点（人）

ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
VDR Tclin Vitamin D receptor (26531 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BDKRB2 Tclin Bradykinin B2 receptor (3970 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRNA4 Tclin Neuronal acetylcholine receptor protein alpha-4 subunit (1265 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MC3R Tchem Melanocortin receptor 3 (5659 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHO-K1 (1115 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Streptavidin (24 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NS1 Nonstructural protein 1 (33327 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slco1a4 Solute carrier organic anion transporter family member 1A4 (114 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cenchrus americanus (77 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Eif4a2 Eukaryotic initiation factor 4A-II (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 200-399-3
分子类型 小分子
IIUPAC Name 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid
INCHI 1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
InChi Key YBJHBAHKTGYVGT-ZKWXMUAHSA-N
Smiles [H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2
Isomeric SMILES C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)NC(=O)N2
分子量 244.31
Beilstein号 86838
Reaxy-Rn 86838
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=86838&ln=

化学和物理性质

密度 1.267
比旋光度 90.5 ° (C=2, 0.1mol/L NaOH)
熔点 232-233°C
分子量 244.310 g/mol
XLogP3 0.300
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 5
精确质量Exact Mass 244.088 Da
单同位素质量Monoisotopic Mass 244.088 Da
拓扑极表面积Topological Polar Surface Area 104.000 Ų
重原子数Heavy Atom Count 16
形式电荷Formal Charge 0
复杂度Complexity 298.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 3
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 1
RTECS XJ9088200
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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批号(Lot Number) 证书类型 货号
H2427105 分析证书 B656921
H2427161 分析证书 B656921
H2427162 分析证书 B656921
H2427103 分析证书 B656921
H2427472 分析证书 B656921
H2427104 分析证书 B656921
H2427475 分析证书 B656921
H2427106 分析证书 B656921

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引用文献

1. Jun Yao.  (2024)  A multiple signal amplification photoelectrochemical biosensor based on biotin-avidin system for kanamycin sensing in fish and milk via synergism of g-C3N4 and Ru@SiO2.  ANALYTICA CHIMICA ACTA,  1288  (342141).  [PMID:38220276] [10.1016/j.aca.2023.342141]
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4. Xinran Wang, Jieyi Pan, Haohui Shi, Na Liang, Shaoping Sun.  (2023)  Biotin-modified acid-sensitive micelles for enhancing antitumor effect of paclitaxel.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  84  (104538).  [10.1016/j.jddst.2023.104538]
5. Qunhuan Ma, Li Zhang.  (2023)  The influences of dissolved inorganic and organic phosphorus on arsenate toxicity in marine diatom Skeletonema costatum and dinoflagellate Amphidinium carterae.  JOURNAL OF HAZARDOUS MATERIALS,  453  (131432).  [PMID:37080037] [10.1016/j.jhazmat.2023.131432]
6. Peiyun Cheng, Na Liang, Wei Zhao, Xianfeng Gong, Weijia Wang, Shaoping Sun.  (2023)  Chitosan-based near-infrared fluorescent micelles for controlled drug delivery and bioimaging in cancer therapy.  EUROPEAN POLYMER JOURNAL,  189  (111974).  [10.1016/j.eurpolymj.2023.111974]
7. Ying Gao, Jie Zhang, Jiexia Pan, Sanjun Ying, Bang Lou, Qingliang Yang, Weiyong Hong, Gensheng Yang.  (2023)  FOF1-ATP synthase molecular motor biosensor for miRNA detection of colon cancer.  LIFE SCIENCES,  319  (121527).  [PMID:36841472] [10.1016/j.lfs.2023.121527]
8. Bin Sun, Zhigang Wang, Bo Zhao, Yanfei Jin, Yaqiang Li, Song Yang.  (2023)  Preparation of biotin-labeled graphene film for detecting nerve growth factor.  International Journal of Electrochemical Science,  18  (100029).  [10.1016/j.ijoes.2023.01.029]
9. Huihui Yang, Xiaosen Bai, Baolong Feng, Qinghua Wang, Li Meng, Fengzhong Wang, Yutang Wang.  (2023)  Application of Molecular Transformer approach for predicting the potential reactions to generate advanced glycation end products in infant formula.  FOOD CHEMISTRY,  407  (135143).  [PMID:36516683] [10.1016/j.foodchem.2022.135143]
10. Qunhuan Ma, Lizhao Chen, Li Zhang.  (2023)  Effects of phosphate on the toxicity and bioaccumulation of arsenate in marine diatom Skeletonema costatum.  SCIENCE OF THE TOTAL ENVIRONMENT,  857  (159566).  [PMID:36265640] [10.1016/j.scitotenv.2022.159566]
11. Qi Han, Wenyi Dong, Hongjie Wang, Boping Yu, Peng Liu, Linshen Xie, Zhiguang Dai.  (2022)  Efficacy of the Toxicity Control during the Degradation of TBBPA by Ozonation.  Water,  14  (16): (2543).  [10.3390/w14162543]
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13. Dan Gao, Sajid Asghar, Junxiu Ye, Mei Zhang, Rongfeng Hu, Yadong Wang, Lin Huang, Chengjun Yuan, Zhipeng Chen, Yanyu Xiao.  (2022)  Dual-targeted enzyme-sensitive hyaluronic acid nanogels loading paclitaxel for the therapy of breast cancer.  CARBOHYDRATE POLYMERS,  294  (119785).  [PMID:35868795] [10.1016/j.carbpol.2022.119785]
14. Lihua Chen, Pan Zhao, Jing Yang, Xiali Liao, Bo Yang, Chuanzhu Gao.  (2022)  Synthesis, characterization, and antitumor biological evaluation of novel fluorine-containing platinum (IV) complexes.  APPLIED ORGANOMETALLIC CHEMISTRY,  36  (7): (e6759).  [10.1002/aoc.6759]
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17. Sida Ruan, Guiying Yang, Yuanzhen Dong, Wenwen Shangguan, Weigen Lu.  (2021)  Discovery of a Long-Acting Parathyroid Hormone 1–34 Analogue to Treat Hypoparathyroidism.  MOLECULAR PHARMACEUTICS,  18  (9): (3260–3271).  [PMID:34482698] [10.1021/acs.molpharmaceut.1c00149]
18. Jing Lv, Meiqiang Xie, Shufen Zhao, Wensheng Qiu, Shasha Wang, Manming Cao.  (2021)  Synergetic fabrication of hybrid drug formulation using biodegradable tri-block copolymeric liquid nanoparticle delivery for gastric cancer chemotherapy.  JOURNAL OF MOLECULAR LIQUIDS,  340  (117066).  [10.1016/j.molliq.2021.117066]
19. Zhao Wang, Bin Liu, Qianqian Sun, Lili Feng, Fei He, Piaoping Yang, Shili Gai, Zewei Quan, Jun Lin.  (2021)  Upconverted Metal–Organic Framework Janus Architecture for Near-Infrared and Ultrasound Co-Enhanced High Performance Tumor Therapy.  ACS Nano,  15  (7): (12342–12357).  [PMID:34160201] [10.1021/acsnano.1c04280]
20. Haohui Shi, Na Liang, Jiyang Liu, Siyi Li, Xianfeng Gong, Pengfei Yan, Shaoping Sun.  (2021)  AIE-active polymeric micelles based on modified chitosan for bioimaging-guided targeted delivery and controlled release of paclitaxel.  CARBOHYDRATE POLYMERS,  269  (118327).  [PMID:34294339] [10.1016/j.carbpol.2021.118327]
21. Xueqing Guo, Yang Liu, Wenjuan Dong, Qin Hu, Yong Li, Shaomin Shuang, Chuan Dong, Lishuai Cai, Xiaojuan Gong.  (2021)  Azithromycin detection in cells and tablets by N,S co-doped carbon quantum dots.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  252  (119506).  [PMID:33561684] [10.1016/j.saa.2021.119506]
22. Xiuling Ji, Suping Wang, Yiyong Luo, Xiaotian Yuan, Yunlin Wei, Qi Zhang, Kunhao Qin, Yujiao Tu.  (2021)  Green synthesis of weissella-derived fluorescence carbon dots for microbial staining, cell imaging and dual sensing of vitamin B12 and hexavalent chromium.  DYES AND PIGMENTS,  184  (108818).  [10.1016/j.dyepig.2020.108818]
23. Hailong Tian, Jing Zhang, Huiyuan Zhang, Yue Jiang, Aixin Song, Yuxia Luan.  (2020)  Low side-effect and heat-shock protein-inhibited chemo-phototherapy nanoplatform via co-assembling strategy of biotin-tailored IR780 and quercetin.  CHEMICAL ENGINEERING JOURNAL,  382  (123043).  [10.1016/j.cej.2019.123043]
24. Zhang Yingyi, Li Liang, Wang Qi, Shen Mei, Han Weili, Yang Xuemei, Chen Lingyun, Ma Ande, Zhou Zhengzheng.  (2019)  Simultaneous determination of metabolic and elemental markers in methamphetamine-induced hepatic injury to rats using LC-MS/MS and ICP-MS.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  411  (15): (3361-3372).  [PMID:31119349] [10.1007/s00216-019-01810-5]
25. Menglu Xu, Sajid Asghar, Shuang Dai, Yajing Wang, Shanshan Feng, Liang Jin, Feng Shao, Yanyu Xiao.  (2019)  Mesenchymal stem cells-curcumin loaded chitosan nanoparticles hybrid vectors for tumor-tropic therapy.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  134  (1002).  [PMID:31063785] [10.1016/j.ijbiomac.2019.04.201]
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