BrBzGCp2

COA

级别和纯度:

≥98%

CAS编号: 166038-00-2
分子式: C₂₇H₃₈BrN₃O₆S
分子量: 612.58
PubChem编号: 127939

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货号 (SKU)	包装规格	是否现货
B651195-5mg	5mg	期货
B651195-10mg	10mg	期货
B651195-25mg	25mg	期货
B651195-50mg	50mg	期货
B651195-100mg	100mg	期货

查看相关系列

Glucose Metabolism (3713) Glyoxalase (GLO) (7) Metabolic Enzyme/Protease (4889)

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基本描述

别名	溴苯
英文别名	AKOS040746203 \| S-4-Bromobenzylglutathione cyclopentyl diester \| Cyclopentyl N5-((R)-3-((4-bromobenzyl)thio)-1-((2-(cyclopentyloxy)-2-oxoethyl)amino)-1-oxopropan-2-yl)-L-glutaminate \| HY-136684 \| MS-30713 \| cyclopentyl (2S)-2-amino-5-[[(2R)-3-[(4-bromophe
规格或纯度	≥98%
英文名称	BrBzGCp2
生化机理	BrBzGCp2 是一种糖醛酸酶 1 (GLO1) 抑制剂，在 HL-60 细胞中的 GC 50 为 4.23 μM。BrBzGCp2 具有抗肿瘤和神经保护活性。
储存温度	-20°C储存,充氩
运输条件	超低温冰袋运输
产品介绍	BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC 50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity In Vivo GLO1 inhibition by BrBzGCp2 increases center time in the OF test, without changing distance traveled. GLO1 inhibition increases MG (methylglyoxal) concentration, thus reducing anxiety-like behavior. BrBzGCp2 pre-treatment decreases seizure duration. BrBzGCp2 injection alleviates the level of anxiety in mice, and mice with less anxiety and fear were more likely to explore the unknown area, implying that inhibition of GLO1 activity mitigated anxiety levels. BrBzGCp2 treatment restores the VPA-induced inhibition effect on GABA A receptor activation. BrBzGCp2 significantly lowers the blood pressure and ameliorated endothelial dysfunction in diabetic mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male CD-1 mice. Dosage: 50 mg/kg. Administration: IP once (Two hours post-injection, mice were sacrificed, and brains were rapidly dissected and flash-frozen on dry ice. MG concentration was measured) Result: Allowed MG levels to accumulate for 2 hours Form:Solid IC50& Target:GC50: 4.23 μM (GLO1)
纯度	≥98%

关联靶点（其它种属）

Glo1 Glyoxalase I (4 活性数据)

点击查看靶蛋白信息： Glo1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IIUPAC Name	cyclopentyl (2S)-2-amino-5-[[(2R)-3-[(4-bromophenyl)methylsulfanyl]-1-[(2-cyclopentyloxy-2-oxoethyl)amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate
INCHI	1S/C27H38BrN3O6S/c28-19-11-9-18(10-12-19)16-38-17-23(26(34)30-15-25(33)36-20-5-1-2-6-20)31-24(32)14-13-22(29)27(35)37-21-7-3-4-8-21/h9-12,20-23H,1-8,13-17,29H2,(H,30,34)(H,31,32)/t22-,23-/m0/s1
InChi Key	QIFSPGPRHFNZNN-GOTSBHOMSA-N
Smiles	C1CCC(C1)OC(=O)CNC(=O)C(CSCC2=CC=C(C=C2)Br)NC(=O)CCC(C(=O)OC3CCCC3)N
Isomeric SMILES	C1CCC(C1)OC(=O)CNC(=O)[C@H](CSCC2=CC=C(C=C2)Br)NC(=O)CC[C@@H](C(=O)OC3CCCC3)N
PubChem CID	127939
分子量	612.58

化学和物理性质

溶解性	DMSO : 250 mg/mL (408.11 mM; Need ultrasonic)
分子量	612.600 g/mol
XLogP3	3.500
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	8
可旋转键计数Rotatable Bond Count	16
精确质量Exact Mass	611.166 Da
单同位素质量Monoisotopic Mass	611.166 Da
拓扑极表面积Topological Polar Surface Area	162.000 Å²
重原子数Heavy Atom Count	38
形式电荷Formal Charge	0
复杂度Complexity	783.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	2
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

RIDADR	NONHforallmodesoftransport

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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