| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B608103-5mg |
5mg |
期货  |
| |
| B608103-25mg |
25mg |
期货 |
|
| 别名 | 北京G-05-039 |
|---|---|
| 规格或纯度 | Moligand™ |
| 英文名称 | BJG-05-039 |
| 作用类型 | 变构调节剂 |
| 作用机制 | p21 (RAC1) 激活激酶 1 的异构调节器 |
| IIUPAC Name | (3S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)pyrrolidine-1-carboxamide |
|---|---|
| INCHI | 1S/C41H44ClF3N8O5/c42-24-10-12-31-28(20-24)37(49-30-21-25(43)11-13-32(30)52(31)23-34(44)45)48-26-16-19-51(22-26)41(58)47-18-6-4-2-1-3-5-17-46-29-9-7-8-27-36(29)40(57)53(39(27)56)33-14-15-35(54)50-38(33)55/h7-13,20-21,26,33-34,46H,1-6,14-19,22-23H2,(H,47,58)(H,48,49)(H,50,54,55)/t26-,33?/m1/s1 |
| InChi Key | UZPKWEBZEBROEX-UOQVMRJOSA-N |
| Smiles | O=C1CCC(N2C(=O)c3cccc(NCCCCCCCCNC(=O)N4CC[C@@H](NC5=Nc6cc(F)ccc6N(CC(F)F)c6ccc(Cl)cc56)C4)c3C2=O)C(=O)N1 |
| PubChem CID | 165437866 |
| 1. Hawley E, Gehlhausen J, Karchugina S, Chow HY, Araiza-Olivera D, Radu M, Smith A, Burks C, Jiang L, Li X et al.. (2021) PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2).. Hum Mol Genet, 30 (17): (1607-1617). [PMID:34075397] |
| 2. Chow HY, Karchugina S, Groendyke BJ, Toenjes S, Hatcher J, Donovan KA, Fischer ES, Abalakov G, Faezov B, Dunbrack R et al.. (2022) Development and Utility of a PAK1-Selective Degrader.. J Med Chem, [PMID:36416208] [10.1021/acs.jmedchem.2c00756] |
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