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对羟基苯甲酸正丁酯
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B427021-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 尼泊金丁酯,4-羟基苯甲酸丁酯 |
|---|---|
| 英文别名 | BUTYLPARABEN | Butyl 4-hydroxybenzoate | 94-26-8 | Butyl paraben | Butyl p-hydroxybenzoate | Butyl parahydroxybenzoate | Nipabutyl | Butoben | Butyl chemosept | Butyl parasept | Tegosept B | Butyl tegosept | Butyl butex | Tegosept Butyl | Aseptoform butyl | Preserval B | Solbrol B | n-But |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Butyl 4-hydroxybenzoate |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
微有特殊气味,溶于醇、醚和氯仿,难溶于水,口尝时有麻舌感。 |
关联靶点（人）
CYP1A2
Tchem
细胞色素 P450 1A2(Cytochrome P450 1A2)
(1 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
TSHR
Tclin
Thyroid stimulating hormone receptor
(29986 活性数据)
PPARG
Tclin
Peroxisome proliferator-activated receptor gamma
(15191 活性数据)
THRB
Tclin
Thyroid hormone receptor beta-1
(7926 活性数据)
NR1H4
Tclin
Bile acid receptor FXR
(6228 活性数据)
RNASEL
Tchem
RNase L
(193 活性数据)
CYP2D6
Tclin
Cytochrome P450 2D6
(33882 活性数据)
CYP1A2
Tchem
Cytochrome P450 1A2
(26471 活性数据)
CYP2C9
Tchem
Cytochrome P450 2C9
(32119 活性数据)
CYP2C19
Tchem
Cytochrome P450 2C19
(29246 活性数据)
CYP3A4
Tclin
Cytochrome P450 3A4
(53859 活性数据)
NR1H2
Tchem
LXR-beta
(3841 活性数据)
MCF7
(126967 活性数据)
GNAS
Tbio
Guanine nucleotide-binding protein G(s), subunit alpha
(103405 活性数据)
SMN1
Tchem
Survival motor neuron protein
(34246 活性数据)
LMNA
Tbio
Prelamin-A/C
(36751 活性数据)
GMNN
Tbio
Geminin
(128009 活性数据)
PMP22
Tbio
Peripheral myelin protein 22
(699 活性数据)
microRNA 21
(64692 活性数据)
CBX1
Tbio
Chromobox protein homolog 1
(92434 活性数据)
ATAD5
Tbio
ATPase family AAA domain-containing protein 5
(122566 活性数据)
ATXN2
Tbio
Ataxin-2
(54410 活性数据)
关联靶点（其它种属）
Mapk1
MAP kinase ERK2 (650 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
Staphylococcus aureus (210822 活性数据)
Leishmania infantum (5912 活性数据)
Plasmodium falciparum (966862 活性数据)
Trypanosoma cruzi (99888 活性数据)
RBL-2H3 (1162 活性数据)
lef
Anthrax lethal factor (7585 活性数据)
Luciferin 4-monooxygenase (66902 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Nfe2l2
Nuclear factor erythroid 2-related factor 2 (214 活性数据)
Rorc
Nuclear receptor ROR-gamma (89407 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| EC号 | 202-318-7 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | butyl 4-hydroxybenzoate |
| INCHI | 1S/C11H14O3/c1-2-3-8-14-11(13)9-4-6-10(12)7-5-9/h4-7,12H,2-3,8H2,1H3 |
| InChi Key | QFOHBWFCKVYLES-UHFFFAOYSA-N |
| Smiles | CCCCOC(=O)C1=CC=C(C=C1)O |
| Isomeric SMILES | CCCCOC(=O)C1=CC=C(C=C1)O |
| 分子量 | 194.23 |
| Beilstein号 | 1103741 |
| Reaxy-Rn | 1103741 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1103741&ln= |
化学和物理性质
| 闪点(℉) | 181℃ |
|---|---|
| 闪点(℃) | 181℃ |
| 沸点 | 156°C |
| 熔点 | 68-71°C |
| 分子量 | 194.230 g/mol |
| XLogP3 | 3.600 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 194.094 Da |
| 单同位素质量Monoisotopic Mass | 194.094 Da |
| 拓扑极表面积Topological Polar Surface Area | 46.500 Ų |
| 重原子数Heavy Atom Count | 14 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 171.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 2 |
| RTECS | DH1980000 |
| Merck Index | 1584 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Qiuhui Xu, Wenxiang Zhang, Quan Chi, Yuhang Yang, Xi Tan, Jikai Liu, Huaming Xiao, Xian Wang. (2024) A novel magnetic porous organic cage adsorbent for high-efficient removal of endocrine disrupting chemicals from environmental water. CHEMICAL ENGINEERING SCIENCE, 285 (119621). [10.1016/j.ces.2023.119621] |
| 2. Jiangping Cao, Lei Shi, Yifei He, Tingting Wang, Baizhao Zeng, Faqiong Zhao. (2024) An effervescence-assisted microextraction for parabens in foodstuffs based on deep eutectic solvent composed of methyltrioctyl ammonium chloride and decanoic acid. FOOD CHEMISTRY, 433 (137348). [PMID:37683492] [10.1016/j.foodchem.2023.137348] |
| 3. Jia Shen, Yating Zhu, Fengmei Zhou, Luyu Wang, Manli Guo, Yujuan Cao. (2023) Phosphorus-Doped Porous Carbon Coated Graphite Felt as An Efficient and Reusable Cathode for Electro-Fenton Degradation of Parabens. ChemElectroChem, 10 (18): (e202300255). [10.1002/celc.202300255] |
| 4. Jiangping Cao, Yifei He, Xiaoshuo Zhang, Lei Shi, Baizhao Zeng, Faqiong Zhao. (2023) Development of a tributyl phosphate-based hydrophobic deep eutectic solvent for liquid-liquid microextraction of total parabens in beverages. JOURNAL OF MOLECULAR LIQUIDS, 387 (122593). [10.1016/j.molliq.2023.122593] |
| 5. Qian Liu, Liulin Wei, Xiaomei Chen, Xueyun Gao, Jingchan Zhao. (2023) Self-collected 3D nano-adsorbent GR@p(POSS-co-DMAEMA) applied to the dispersive solid-phase microextraction in parabens detection of condiments. MICROCHEMICAL JOURNAL, 190 (108640). [10.1016/j.microc.2023.108640] |
| 6. Yan-Yan Liu, Yi-Xin Zhang, Hua-Mei Wen, Xiao-Long Liu, Xin-Jiong Fan. (2023) Cloning and rational modification of a cold-adapted esterase for phthalate esters and parabens degradation. CHEMOSPHERE, 325 (138393). [PMID:36925017] [10.1016/j.chemosphere.2023.138393] |
| 7. Lizhen Qiao, Yuan Tao, Honglin Qin, Ruiting Niu. (2023) Multi-magnetic center ionic liquids for dispersive liquid-liquid microextraction coupled with in-situ decomposition based back-extraction for the enrichment of parabens in beverage samples. JOURNAL OF CHROMATOGRAPHY A, 1689 (463771). [PMID:36610188] [10.1016/j.chroma.2022.463771] |
| 8. Huihui Lv, Yuchao Zhu, Jinping Xue, Xiao Jia, Juanjuan Chen. (2022) Targeted Drug Delivery System Based on Copper Sulfide for Synergistic Near-Infrared Photothermal Therapy/Photodynamic Therapy/Chemotherapy of Triple Negative Breast Cancer. LANGMUIR, 38 (50): (15766–15775). [PMID:36508193] [10.1021/acs.langmuir.2c02667] |
| 9. Yuan Tao, Luyao Jia, Honglin Qin, Ruiting Niu, Lizhen Qiao. (2022) A new magnetic ionic liquid based salting-out assisted dispersive liquid–liquid microextraction for the determination of parabens in environmental water samples. Analytical Methods, 14 (46): (4775-4783). [PMID:36374117] [10.1039/D2AY01403C] |
| 10. Yang Xiao-Shuai, Zhao Jie, Wang Lu-Liang, Liu Yu-Shen, Liu Quan-Wen, Peng Xin-Yan, Wang Ping. (2022) Core–shell-structured magnetic covalent organic frameworks for effective extraction of parabens prior to their determination by HPLC. MICROCHIMICA ACTA, 189 (9): (1-10). [PMID:35995957] [10.1007/s00604-022-05444-w] |
| 11. Jiangping Cao, Lei Shi, Yifei He, Yuwen Liu, Faqiong Zhao. (2022) Effective extraction of parabens from toothpaste by vortex-assisted liquid-phase microextraction based on low viscosity deep eutectic solvent. MICROCHEMICAL JOURNAL, 179 (107590). [10.1016/j.microc.2022.107590] |
| 12. Xun Gao, Kai Xu, Miaomiao Chi, Jiaojiao Li, Lingzhe Suo, Lin Zhu, Kexin Chen, Jingqing Mu. (2021) Determination of four parabens in cosmetics by high-performance liquid chromatography with magnetic solid-phase and ionic dispersive liquid–liquid extraction. REVIEWS IN ANALYTICAL CHEMISTRY, 40 (1): (161-172). [10.1515/revac-2021-0133] |
| 13. Min-Ping Zhu, Jia-Cheng E. Yang, Xiaoguang Duan, Shaobin Wang, Darren Delai Sun, Baoling Yuan, Ming-Lai Fu. (2021) Engineered Co2AlO4/CoAl2O4@Al2O3 monolithic catalysts for peroxymonosulfate activation: Co3+/Co2+ and ODefect/OLattice ratios dependence and mechanism. CHEMICAL ENGINEERING JOURNAL, 409 (128162). [10.1016/j.cej.2020.128162] |
| 14. Wan-Jun Long, Hai-Long Wu, Tong Wang, Ming-Yue Dong, Ru-Qin Yu. (2021) Interference-free analysis of multi-class preservatives in cosmetic products using alternating trilinear decomposition modeling of liquid chromatography diode array detection data. MICROCHEMICAL JOURNAL, 162 (105847). [10.1016/j.microc.2020.105847] |
| 15. Shijie Sun, Hongyu Deng, Jinfeng Yang, Dongxu Zhou, Xing Wan, Fengxia Han. (2020) Photodegradation of Butyl 4-Hydroxybenzoate in the Presence of Peroxides and Mediated by Dissolved Organic Matter. ENVIRONMENTAL ENGINEERING SCIENCE, 37 (7): (497-508). [10.1089/ees.2019.0481] |
| 16. Chen Chen, Lei Xu, Jiang-Bo Huo, Kiran Gupta, Ming-Lai Fu. (2020) Simultaneous removal of butylparaben and arsenite by MOF-derived porous carbon coated lanthanum oxide: Combination of persulfate activation and adsorption. CHEMICAL ENGINEERING JOURNAL, 391 (123552). [10.1016/j.cej.2019.123552] |
| 17. Yangqing He, Zhengrui Huang, Zhanying Ma, Binghua Yao, Haiyang Liu, Linlin Hu, Qing Zhao, Qian Yang, Dongjie Liu, Deguo Du. (2019) Highly efficient photocatalytic performance and mechanism of α-ZnTcPc/g-C3N4 composites for methylene blue and tetracycline degradation under visible light irradiation. APPLIED SURFACE SCIENCE, 498 (143834). [10.1016/j.apsusc.2019.143834] |
| 18. Ge Dandan, Wang Ying, Jiang Qian, Dai Enrui. (2019) A Deep Eutectic Solvent as an Extraction Solvent to Separate and Preconcentrate Parabens in Water Samples Using in situ Liquid-Liquid Microextraction. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 30 (6): (1203-1210). [10.21577/0103-5053.20190014] |
| 19. Junjie Guo, Xianfang Meng, Hongwei Zhu, Mengmeng Sun, Yibo Wang, Weina Wang, Mingyu Xing, Fei Zhang. (2019) Boosting the performance and stability of perovskite solar cells with phthalocyanine-based dopant-free hole transporting materials through core metal and peripheral groups engineering. ORGANIC ELECTRONICS, 64 (71). [10.1016/j.orgel.2018.09.045] |
| 20. Xiao-Li Yin, Hui-Wen Gu, Ali R. Jalalvand, Ya-Juan Liu, Ying Chen, Tian-Qin Peng. (2018) Dealing with overlapped and unaligned chromatographic peaks by second-order multivariate calibration for complex sample analysis: Fast and green quantification of eight selected preservatives in facial masks. JOURNAL OF CHROMATOGRAPHY A, 1573 (18). [PMID:30243735] [10.1016/j.chroma.2018.09.019] |
| 21. Li Shuo, Jia Mengtian, Guo Hongqiao, Hou Xiaohong. (2018) Development and application of metal organic framework/chitosan foams based on ultrasound-assisted solid-phase extraction coupling to UPLC-MS/MS for the determination of five parabens in water. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (25): (6619-6632). [PMID:30062509] [10.1007/s00216-018-1269-2] |
| 22. Mao Qianhui, Ji Feng, Wang Wei, Wang Qiquan, Hu Zhenhu, Yuan Shoujun. (2016) Chlorination of parabens: reaction kinetics and transformation product identification. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 23 (22): (23081-23091). [PMID:27585586] [10.1007/s11356-016-7499-y] |
| 23. Xiaoxiao You, Chungying Piao, Ligang Chen. (2016) Preparation of a magnetic molecularly imprinted polymer by atom-transfer radical polymerization for the extraction of parabens from fruit juices. JOURNAL OF SEPARATION SCIENCE, 39 (14): (2831-2838). [PMID:27214157] [10.1002/jssc.201600335] |
| 24. Yi Zhang, Yan Zhang, Guan Wang, Wujuan Chen, Pingang He, Qingjiang Wang. (2016) Synthesis and characterization of a multimode stationary phase: Congo red derivatized silica in nano-flow HPLC. ANALYST, 141 (3): (1083-1090). [PMID:26646316] [10.1039/C5AN02021B] |
| 25. Bingbing Sun, Li Qi, Minglin Wang. (2014) Determination of preservatives in soft drinks by capillary electrophoresis with ionic liquids as the electrolyte additives. JOURNAL OF SEPARATION SCIENCE, 37 (16): (2248-2252). [PMID:24910409] [10.1002/jssc.201400444] |
| 26. Yang Jinling, Li Yongxin, Gong Weilei, Wang Changqin, Liu Bencheng, Sun Chengjun. (2014) Simultaneous Determination of Six Parabens in Foods by Matrix Liquid-Phase Dispersion Extraction Combined with High-Performance Liquid Chromatography. Food Analytical Methods, 7 (8): (1693-1702). [10.1007/s12161-014-9807-9] |
| 27. Yang Qiu,Chao Wu,Jie Jiang,Yanna Hao,Ying Zhao,Jie Xu,Tong Yu,Peng Ji. (2016-12-19) Lipid-coated hollow mesoporous silica nanospheres for co-delivery of doxorubicin and paclitaxel: Preparation, sustained release, cellular uptake and pharmacokinetics.. Materials science & engineering. C, Materials for biological applications, 71 (835-843). [PMID:27987779] |
| 28. Haining Du, Lili Cui, Xinyi Zhao, Ziteng Yu, Tianyue He, Boya Zhang, Xingpei Fan, Meimei Zhao, Ruijiao Zhu, Ziyi Zhang, Mengcong Li, Jiaxin Li, Yuri Oh, Ning Gu. (2024) Butylparaben induces glycolipid metabolic disorders in mice via disruption of gut microbiota and FXR signaling. JOURNAL OF HAZARDOUS MATERIALS, 474 (134821). [PMID:38850927] [10.1016/j.jhazmat.2024.134821] |
| 29. Zheng Hu, Yuhang Yang, Zhe Li, Qiuying Tao, Yinghong Huang, Xian Wang. (2025) Efficient enrichment and sensitive determination of endocrine disruptors in PPCPs by novel magnetic covalent organic framework extraction coupled with HPLC-MS/MS. TALANTA, 287 (127667). [PMID:39892117] [10.1016/j.talanta.2025.127667] |
| 30. Zhong-Hong Zhang, Jian-Wei Zheng, Si-Fen Liu, Ting-Bin Hao, Wei-Dong Yang, Hong-Ye Li, Xiang Wang. (2024) Impact of butylparaben on growth dynamics and microcystin-LR production in Microcystis aeruginosa. ENVIRONMENTAL RESEARCH, 257 (119291). [PMID:38823607] [10.1016/j.envres.2024.119291] |
| 31. Hang Ning, Wen-long Liu, Qing-yun Li, You-yan Liu, Shi-ting Huang, Hai-bo Liu, Ai-xing Tang. (2024) Substrate Characterization for Hydrolysis of Multiple Types of Aromatic Esters by Promiscuous Aminopeptidases. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 72 (30): (16867-16876). [PMID:39021280] [10.1021/acs.jafc.4c02053] |