| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B424113-1ml |
1ml |
现货  |
|
| 英文别名 | (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylicacid | Prestwick3_000417 | Prestwick0_000417 | BETULINIC ACID [INCI |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Betulinic acid |
| 生化机理 | 白桦脂酸，五环三萜，通过P53-CD95独立机制直接激活线粒体凋亡途径，从而选择性地诱导肿瘤细胞凋亡。三萜具有各种生物活性。凋亡诱导剂，具有抗癌特性。还显示出抗HIV，抗疟疾和抗炎活性。TGR5激动剂（EC 50 = 1.04μM）。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | GPBA 受体激动剂 |
| 产品介绍 |
白桦脂酸（BETA）可用于研究其通过P53-CD95独立机制激活线粒体凋亡途径的功能和活性。白桦脂酸还是用来研究其潜在在内皮依赖性舒张方面的心血管作用机制。 Betulinic acid (BetA) may be used to study its function and activity as an activator of mitochondrial pathway apoptosis involving p53- and CD95-independent mechanisms. Betulinic acid is used to study its potential cardiovascular role in the modulation of endothelium-dependent relaxation. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 207-448-8 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid |
| INCHI | 1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1 |
| InChi Key | QGJZLNKBHJESQX-FZFNOLFKSA-N |
| Smiles | CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O |
| Isomeric SMILES | CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O |
| 分子量 | 456.7 |
| Reaxy-Rn | 2228573 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2228573&ln= |
| 比旋光度 | 7.8 ° (C=0.9, Pyridine) |
|---|---|
| 熔点 | 295-298°C |
| 分子量 | 456.700 g/mol |
| XLogP3 | 8.200 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 456.36 Da |
| 单同位素质量Monoisotopic Mass | 456.36 Da |
| 拓扑极表面积Topological Polar Surface Area | 57.500 Ų |
| 重原子数Heavy Atom Count | 33 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 861.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 10 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| WGK Germany | 3 |
|---|---|
| Merck Index | 1190 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
| 1. Shuai-Nan Zhang, Qi Liu, Xu-Zhao Li, Wu-De Yang, Ying Zhou. (2024) Sophora tonkinensis and active compounds inhibit mitochondrial impairments, inflammation, and LDLR deficiency in myocardial ischemia mice through regulating the vesicle-mediated transport pathway. FITOTERAPIA, 172 (105756). [PMID:38007052] [10.1016/j.fitote.2023.105756] |
| 2. Xuan Chen, Shuting Lu, Fengrong Gong, Xiaoyu Sui, Tingting Liu, Ting Wang. (2022) Research on the synthesis of nanoparticles of betulinic acid and their targeting antitumor activity. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 110 (8): (1789-1795). [PMID:35179806] [10.1002/jbm.b.35036] |
| 3. Shuai-nan Zhang, Ya-feng He, Xu-zhao Li, Wu-de Yang, Ying Zhou. (2021) Biolabel-led research pattern positions the effects and mechanisms of Sophorae Tonkinensis radix et rhizome on lung diseases: A novel strategy for computer-aided herbal medicine research based on omics and bioinformatics. COMPUTERS IN BIOLOGY AND MEDICINE, 136 (104769). [PMID:34426169] [10.1016/j.compbiomed.2021.104769] |
| 4. Dongli Li, Zhiyun Du, Chenyue Li, Yue Liu, Susan Goodin, Huarong Huang, Yan He, Yuan Zhang, Huaqian Wang, Xi Zheng, Kun Zhang. (2015) Potent inhibitory effect of terpenoids from Acanthopanax trifoliatus on growth of PC-3 prostate cancer cells in vitro and in vivo is associated with suppression of NF-κB and STAT3 signalling. Journal of Functional Foods, 15 (274). [10.1016/j.jff.2015.03.035] |
| 5. Qisi Lin, Ling Zhang, Dongzhi Yang, Zhao Chunjie. (2014) Contribution of Phenolics and Essential Oils to the Antioxidant and Antimicrobial Properties of Disporopsis pernyi (Hua) Diels. JOURNAL OF MEDICINAL FOOD, 17 (6): (714-722). [PMID:24797793] [10.1089/jmf.2013.2905] |
| 6. Yan Liu, Zhuofeng Ke, Kwok Yiu Wu, Shuwen Liu, Wen-Hua Chen, Shibo Jiang, Zhi-Hong Jiang. (2011) An Amphiphilic Conjugate Approach toward the Design and Synthesis of Betulinic Acid–Polyphenol Conjugates as Inhibitors of the HIV-1 gp41 Fusion Core Formation. ChemMedChem, 6 (9): (1654-1664). [PMID:21688394] [10.1002/cmdc.201100149] |
| 7. Shuping Liu, Qingqing Zhang, Xiaohua Zhang, Cuicui Du, Jinhua Chen, Shihui Si. (2024) Real-time monitoring of dephosphorylation process of phosphopeptide and rapid assay of PTP1B activity based on a 100 MHz QCM biosensing platform. TALANTA, 277 (126399). [PMID:38876030] [10.1016/j.talanta.2024.126399] |
| 8. Wen Zhong, Huanan Jia, Haiyan Zhu, Yuan Tian, Wei Huang, Qiyue Yang. (2024) Sarcopenia is attenuated by mairin in SAMP8 mice via the inhibition of FAPs fibrosis through the AMPK-TGF-β-SMAD axis. GENE, 931 (148873). [PMID:39159793] [10.1016/j.gene.2024.148873] |
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