| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B420401-1ml |
1ml |
现货  |
|
| 别名 | 刺棒棕果汁 |
|---|---|
| 英文别名 | 4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol | 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dien-1-yl]phenol | BAKUCHIOL [INCI] | 4-[(1E,3S)-3,7-dimethyl-3-vinyl-octa-1,6-dienyl]phenol | DTXSID401035664 | 4,2-dithiacyclopentenone | 3,5-Dihydroxytoluene (O |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Bakuchiol |
| 生化机理 | 白藜芦醇类似物。各种药理活动。体外具有抗癌，凋亡，抗炎，抗氧化和抗菌活性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Bakuchiol is an antioxidant inhibitor of protein tyrosine phosphatase 1B (PTP1B). It also acts as an inhibitor of mitochondrial lipid peroxidation and inducible nitric oxide synthase (iNOS; NOS II) expression. Bakuchiol is also a DNA polymerase inhibitor which shows antimicrobial and cytotoxic activity. Bakuchiol is an antioxidant inhibitor of protein tyrosine phosphatase 1B (PTP1B). It also acts as an inhibitor of mitochondrial lipid peroxidation and inducible nitric oxide synthase (iNOS; NOS II) expression. Bakuchiol is also a DNA polymerase inhibitor which shows antimicrobial and cytotoxic activity. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol |
| INCHI | 1S/C18H24O/c1-5-18(4,13-6-7-15(2)3)14-12-16-8-10-17(19)11-9-16/h5,7-12,14,19H,1,6,13H2,2-4H3/b14-12+/t18-/m1/s1 |
| InChi Key | LFYJSSARVMHQJB-QIXNEVBVSA-N |
| Smiles | CC(=CCCC(C)(C=C)C=CC1=CC=C(C=C1)O)C |
| Isomeric SMILES | CC(=CCC[C@@](C)(C=C)/C=C/C1=CC=C(C=C1)O)C |
| 分子量 | 256.38 |
| Beilstein号 | 3611720 |
| Reaxy-Rn | 15028537 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=15028537&ln= |
| 敏感性 | 对空气敏感 |
|---|---|
| 闪点(℉) | 177℃ |
| 闪点(℃) | 177℃ |
| 沸点 | 391℃ |
| 分子量 | 256.399 g/mol |
| XLogP3 | 6.100 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 1 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 256.183 Da |
| 单同位素质量Monoisotopic Mass | 256.183 Da |
| 拓扑极表面积Topological Polar Surface Area | 20.200 Ų |
| 重原子数Heavy Atom Count | 19 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 328.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS09 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H332: 吸入有害 H335: 可能引起呼吸道刺激 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P391: 收集溢出物 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P501: 将内容物/容器处理到。。。 |
| WGK Germany | 3 |
| 1. Feng Li, Shuai Wang, Danyi Lu, Yifei Wang, Dong Dong, Baojian Wu. (2017) Identification of UDP-glucuronosyltransferases 1A1, 1A3 and 2B15 as the main contributors to glucuronidation of bakuchiol, a natural biologically active compound. XENOBIOTICA, 47 (5): (369-375). [PMID:27314830] [10.1080/00498254.2016.1195523] |
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