| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B407931-1ml |
1ml |
现货  |
|
| 英文别名 | N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | BMS-794833 |
| 生化机理 | BMS-794833 是 Met (c-Met)/VEGFR2 的强效 ATP 竞争性抑制剂，IC50 为 1.7 nM/15 nM，还能抑制 Ron、Axl 和 Flt3，IC50 <3 nM；是 BMS-817378 的原药。第一阶段。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | MER 原癌基因抑制剂；酪氨酸激酶 |
| 产品介绍 |
BMS-794833是一种有效的，ATP竞争性Met (c-Met)/VEGFR2抑制剂，IC50为1.7 nM/15 nM，也抑制Ron， Axl和Flt3，IC50低于3 nM；是BMS-817378的前体药物。 Information BMS-794833 is a potent ATP competitive inhibitor ofMet (c-Met)/VEGFR2withIC50of 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3 with IC50 of <3 nM; a prodrug of BMS-817378. Phase 1. BMS794833 also inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with IC50 of 39 nM. In vivo In GTL-16 human gastric tumor xenografts model, BMS798433 shows greater than 50% TGI for at least one tumor doubling time with no overt toxicity observed during 14 days. BMS798433 also shows complete tumor stasis at a dose of 25 mg/kg against U87 glioblastoma model. cell lines： Concentrations：~ 1 μM Incubation Time：72 hours Powder Purity:≥99% |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | C1=CC(=CC=C1C2=CNC=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)F |
| 关联CAS | 1174046-72-0 |
| MeSH Entry Terms | BMS794833;N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide |
| 分子量 | 468.84 |
| Reaxy-Rn | 19432284 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19432284&ln= |
| 溶解性 | Solubility (25°C) In vitro DMSO: 65 mg/mL (199.14 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|
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