双环醇

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货号 (SKU)	包装规格	是否现货
B166247-5mg	5mg	现货
B166247-10mg	10mg	现货
B166247-25mg	25mg	现货
B166247-50mg	50mg	现货
B166247-100mg	100mg	现货

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Amino Acid/Protein Metabolism (4559) Anti-infection (2804) Apoptosis (7108) Autophagy (2848) Cell Cycle (7376) DNA Damage (3514) Extrinsic Pathway (1228) Ferroptosis (624) Glucose Metabolism (3713) HBV (113) Intrinsic Pathway (1438) Virus (3767) 膜转运体 (1142)

英文别名	4,4'-Bi-1,3-benzodioxole)-5-carboxylic acid, 5'-(hydroxymethyl)-7,7'-dimethoxy-, methyl ester \| 5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bi-1,3-benzodioxole]-5-carboxylic acid, methyl ester \| s6453 \| AKOS016007877 \| Q27271958 \| SY801 \| HY-B0766 \| BCP25554
规格或纯度	≥98%(HPLC)
英文名称	Bicyclol
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Bicyclol (SY-801)是一种能够改善肝功能、抑制HBV复制的药物。 Product Introduction Bicyclol(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibiting HBV and HCV replication. In combination therapy of bicyclol with interferon alpha, lamivudine and adefovir dipivoxil in HBV or HCV, bicyclol may reduce YMDD mutant and side effects and increase the anti-viral efficacy.
纯度	≥98%(HPLC)

PubChem SID	488196331
分子类型	小分子
IIUPAC Name	methyl 4-[5-(hydroxymethyl)-7-methoxy-1,3-benzodioxol-4-yl]-7-methoxy-1,3-benzodioxole-5-carboxylate
INCHI	1S/C19H18O9/c1-22-11-4-9(6-20)13(17-15(11)25-7-27-17)14-10(19(21)24-3)5-12(23-2)16-18(14)28-8-26-16/h4-5,20H,6-8H2,1-3H3
InChi Key	KXMTXZACPVCDMH-UHFFFAOYSA-N
Smiles	COC1=C2C(=C(C(=C1)CO)C3=C4C(=C(C=C3C(=O)OC)OC)OCO4)OCO2
Isomeric SMILES	COC1=C2C(=C(C(=C1)CO)C3=C4C(=C(C=C3C(=O)OC)OC)OCO4)OCO2
分子量	390.34
Reaxy-Rn	10384816
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10384816&ln=

溶解性	DMSO: 68 mg/mL
分子量	390.300 g/mol
XLogP3	2.100
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	9
可旋转键计数Rotatable Bond Count	6
精确质量Exact Mass	390.095 Da
单同位素质量Monoisotopic Mass	390.095 Da
拓扑极表面积Topological Polar Surface Area	102.000 Å²
重原子数Heavy Atom Count	28
形式电荷Formal Charge	0
复杂度Complexity	558.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

象形图	GHS09
信号词	警告
危险声明	H400: 对水生生物有剧毒
预防措施声明	P273: 避免释放到环境中。 P391: 收集溢出物 P501: 将内容物/容器处理到。。。
RTECS	DT4312000
个人防护装备	dust mask type N95 (US)， Eyeshields， Gloves

基本描述

1. Qu-Jing Luo, Wen-Chao Zhou, Xin-Yi Liu, Ya-Jie Li, Qing-Ling Xie, Bin Wang, Chao Liu, Wen-Mao Wang, Wei Wang, Xu-Dong Zhou. (2023) Chemical Constituents and α-Glucosidase Inhibitory, Antioxidant and Hepatoprotective Activities of Ampelopsis grossedentata. MOLECULES, 28 (24): (7956). [PMID:38138447] [10.3390/molecules28247956]
2. Fengping Chen, Haizhu Zou, Ping Zhang, Yuqi Yan. (2023) Investigation on the in vitro metabolism of bicyclol using liver microsomes, hepatocytes and human recombinant cytochrome P450 enzymes. XENOBIOTICA, [PMID:37272731] [10.1080/00498254.2023.2222385]