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双酚A二缩水甘油醚（BADGE）

选择性PPARγ拮抗剂
76篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
B131786-25g
 25g 期货 Stock Image
B131786-100g
 100g 现货 Stock Image
B131786-500g
 500g 现货 Stock Image
B131786-2.5kg
 2.5kg 期货 Stock Image
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无卤杂环砌块 (1210) 环氧乙烷类 (71)
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基本描述

别名 2,2-双(4-环氧丙氧基苯基)丙烷 | 2,2-二[4-(氧化缩水甘油)苯基]丙烷 | 4,4'-异亚丙基联苯酚二缩水甘油醚 | 2,2-双(4-羟苯基)丙烷二环氧甘油醚
英文别名 BADGE | 4,4'-Isopropylidenebis[1-(2,3-epoxypropoxy)benzene] | BISPHENOL A DIGLYCIDYL ETHER RESIN | BSPBio_001468 | 2,2-bis(4-(2,3-epoxypropoxy)phenyl)propane | 2,2-bis(4-(2,3-epoxypropoxy)phenyl)-propane | Bio1_001356 | 2,2-Bis(p-hydroxyphenyl)propane dig
规格或纯度 Moligand™, ≥85%
英文名称 Bisphenol A Diglycidyl Ether（BADGE）
生化机理 选择性PPARγ拮抗剂。诱导非PPARγ依赖性肿瘤细胞凋亡。增加体内成骨细胞生成和骨量。
应用 An inhibitor of PPARγ and suppressor of TNFα.
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

Bisphenol A Diglycidyl Ether is a diglycidyl ether (BADGE) can inhibit the peroxisome proliferator-activated receptor (PPARγ) and adipocyte differentiation, and has been shown to induce apoptosis in tumor cells. Research shows that BADGE can suppress the tumor necrosis factor-α (TNF-α) and that it has the ability to induce F-actin depolymerization.An inhibitor of PPARγ and suppressor of TNFα.

Bisphenol A Diglycidyl Ether is a diglycidyl ether (BADGE) can inhibit the peroxisome proliferator-activated receptor (PPARγ) and adipocyte differentiation, and has been shown to induce apoptosis in tumor cells. Research shows that BADGE can suppress the tumor necrosis factor-α (TNF-α) and that it has the ability to induce F-actin depolymerization.
An inhibitor of PPARγ and suppressor of TNFα.
纯度 ≥85%

关联靶点（人）

ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
VDR Tclin Vitamin D receptor (26531 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Lymphoblastoid cell (5959 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Ppard Peroxisome proliferator-activated receptor delta (358 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
H4 (48 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FTL Ferritin light chain (43324 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 未知
IIUPAC Name 2-[[4-[2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]phenoxy]methyl]oxirane
INCHI 1S/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3
InChi Key LCFVJGUPQDGYKZ-UHFFFAOYSA-N
Smiles CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4
Isomeric SMILES CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4
分子量 340.42
Reaxy-Rn 299026
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=299026&ln=

化学和物理性质

溶解性 Soluble in 100% ethanol, DMSO (100 mM), DMF, chloroform, methanol, and ethanol (50 mM). Insoluble in PBS, pH 7.2, and water.
密度 1.17
敏感性 对热、湿度敏感
折光率 1.57
沸点 210 °C/1 mmHg
分子量 340.400 g/mol
XLogP3 4.000
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 8
精确质量Exact Mass 340.167 Da
单同位素质量Monoisotopic Mass 340.167 Da
拓扑极表面积Topological Polar Surface Area 43.500 Ų
重原子数Heavy Atom Count 25
形式电荷Formal Charge 0
复杂度Complexity 384.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 2
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07,   GHS09
信号词 警告
危险声明

H315: 引起皮肤刺激

H317: 可能引起皮肤过敏反应

H319: 引起严重眼睛刺激

H411: 对水生生物有毒并具有长期持续影响
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P272: 被污染的工作服不允许离开工作场所

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P302+P352: 如皮肤沾染：用水充分清洗。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P501: 将内容物/容器处理到。。。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。
RTECS TX3800000

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找到31个结果

批号(Lot Number) 证书类型 货号
D2525160 分析证书 B131786
D2525159 分析证书 B131786
D2525161 分析证书 B131786
D2525162 分析证书 B131786
F2313781 分析证书 B131786
F2313801 分析证书 B131786
K2418173 分析证书 B131786
K2418175 分析证书 B131786
K2418176 分析证书 B131786
K2418174 分析证书 B131786
J2414746 分析证书 B131786
J2414740 分析证书 B131786
J2414744 分析证书 B131786
J2414741 分析证书 B131786
J2414861 分析证书 B131786
C2414139 分析证书 B131786
C2414140 分析证书 B131786
F2313782 分析证书 B131786
F2313785 分析证书 B131786
H2405029 分析证书 B131786
D2307489 分析证书 B131786
D2307490 分析证书 B131786
D2307491 分析证书 B131786
L22141011 分析证书 B131786
L22141012 分析证书 B131786
L22141014 分析证书 B131786
L2215044 分析证书 B131786
D2214002 分析证书 B131786
D2214003 分析证书 B131786
D2214004 分析证书 B131786
D2214005 分析证书 B131786

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引用文献

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6. Zicheng Fan, Insub Noh, Changlong Zhuang, Qingqing Liu, Yanbin Wang, Hyung Do Kim, Meng Yue, Hideo Ohkita, Biaobing Wang.  (2023)  A polar polyimide as multifunctional flame retardant for epoxy resin through constructing intimate 3D interpenetrating polymer network.  EUROPEAN POLYMER JOURNAL,  198  (112383).  [10.1016/j.eurpolymj.2023.112383]
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