计算溶液所需的质量、体积或浓度。
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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| B131634-1g |
1g |
现货 ![]() |
| |
| B131634-5g |
5g |
现货 ![]() |
| |
| B131634-10g |
10g |
现货 ![]() |
| |
| B131634-25g |
25g |
现货 ![]() |
|
| 英文别名 | MJ 10061 | Prestwick3_000370 | SPBio_002420 | CPD000058310 | NCGC00013895-08 | Prestwick0_000370 | 3,5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone | Harolan | NCGC00013895 | NCI85433 | Prestwick1_000370 | Opera_ID_1282 | HMS3713I21 | (3,5-dibrom |
|---|---|
| 规格或纯度 | ≥98%(HPLC) |
| 英文名称 | Benzbromarone |
| 生化机理 | TMEM16A / B钙激活的氯离子通道(CaCC)阻滞剂。有力的CYP2C9抑制剂(Ki = 19 nM)。尿酸尿酸药物抑制由尿酸转运蛋白URAT1(SLC22A12)介导的尿酸重吸收。非竞争性黄嘌呤氧化酶抑制剂。 |
| 运输条件 | 常规运输 |
| 备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。有毒,请参阅SDS以获取更多信息。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
| 纯度 | ≥98%(HPLC) |
| ALogP | 5.7 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 488179687 |
|---|---|
| EC号 | 222-630-7 |
| 分子类型 | 小分子 |
| IIUPAC Name | (3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-1-benzofuran-3-yl)methanone |
| INCHI | 1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3 |
| InChi Key | WHQCHUCQKNIQEC-UHFFFAOYSA-N |
| Smiles | CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)Br)O)Br |
| Isomeric SMILES | CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)Br)O)Br |
| 分子量 | 424.08 |
| Reaxy-Rn | 273668 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=273668&ln= |
| 熔点 | 152 °C |
|---|---|
| 分子量 | 424.100 g/mol |
| XLogP3 | 5.700 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 423.913 Da |
| 单同位素质量Monoisotopic Mass | 421.915 Da |
| 拓扑极表面积Topological Polar Surface Area | 50.400 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 405.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 | |
| 分析证书 | B131634 |
| 1. Lin Xiang, Yuting Huang, Rong Li, Yexing Tao, Ting Wu, Siyi Pan, Xiaoyun Xu. (2023) Artemisia selengensis Turcz. leaves extract ameliorates hyperuricemia in mice by inhibiting hepatic xanthine oxidase activity, modulating renal uric acid transporters, and improving metabolic disorders. Food Bioscience, (102639). [10.1016/j.fbio.2023.102639] |
| 2. Jian Gao, Hao Yin, Yanqun Dong, Xintong Wang, Yani Liu, KeWei Wang. (2023) A Novel Role of Uricosuric Agent Benzbromarone in BK Channel Activation and Reduction of Airway Smooth Muscle Contraction. MOLECULAR PHARMACOLOGY, 103 (4): (241-254). [PMID:36669879] [10.1124/molpharm.122.000638] |
| 3. Tianqiao Yong, Danling Liang, Chun Xiao, Longhua Huang, Shaodan Chen, Yizhen Xie, Xiong Gao, Qingping Wu, Huiping Hu, Xiangmin Li, Yuancao Liu, Manjun Cai. (2022) Hypouricemic effect of 2,4-dihydroxybenzoic acid methyl ester in hyperuricemic mice through inhibiting XOD and down-regulating URAT1. BIOMEDICINE & PHARMACOTHERAPY, 153 (113303). [PMID:35750011] [10.1016/j.biopha.2022.113303] |
| 4. Ze-Rui Sun, Hua-Rong Liu, Di Hu, Mao-Si Fan, Ming-Yue Wang, Meng-Fei An, Yun-Li Zhao, Ze-Min Xiang, Jun Sheng. (2021) Ellagic Acid Exerts Beneficial Effects on Hyperuricemia by Inhibiting Xanthine Oxidase and NLRP3 Inflammasome Activation. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69 (43): (12741–12752). [PMID:34672194] [10.1021/acs.jafc.1c05239] |
| 5. Danling Liang, Tianqiao Yong, Xue Diao, Shaodan Chen, Diling Chen, Chun Xiao, Dan Zuo, Yizhen Xie, Xinxin Zhou, Huiping Hu. (2021) Hypouricaemic and nephroprotective effects of Poria cocos in hyperuricemic mice by up-regulating ATP-binding cassette super-family G member 2. PHARMACEUTICAL BIOLOGY, 59 (1): (273-284). [PMID:33651969] [10.1080/13880209.2021.1885450] |
| 6. Qiurui Li, Hua Lin, Yanfen Niu, Yan Liu, Zhenyu Wang, Liudong Song, Lihui Gao, Ling Li. (2020) Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters. EUROPEAN JOURNAL OF PHARMACOLOGY, 888 (173490). [PMID:32827538] [10.1016/j.ejphar.2020.173490] |
| 7. Chen Sun, Mingyu Zhang, Yanhong Zhao, Jianxin Pang, Ying Peng, Jiang Zheng. (2020) An LC-MS/MS- and hURAT1 cell-based approach for screening of uricosuric agents. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1159 (122336). [PMID:32905987] [10.1016/j.jchromb.2020.122336] |
| 8. Renjie Xu, Hongdan Zhu, Lingmin Hu, Beimeng Yu, Xiaohua Zhan, Yichu Yuan, Ping Zhou. (2020) Characterization of the intestinal absorption of morroniside from Cornus officinalis Sieb. et Zucc via a Caco-2 cell monolayer model. PLoS One, 15 (5): (e0227844). [PMID:32470043] [10.1371/journal.pone.0227844] |
| 9. Renjie Xu, Yichu Yuan, Jia Qi, Jia Zhou, Xiaowen Guo, Jian Zhang, Ruanjuan Zhan. (2018) Elucidation of the Intestinal Absorption Mechanism of Loganin in the Human Intestinal Caco-2 Cell Model. Evidence-based Complementary and Alternative Medicine, 2018 (8340563). [PMID:30671130] [10.1155/2018/8340563] |
| 10. Xu Renjie, Peng Ying, Wang Mengyue, Li Xiaobo. (2019) Intestinal Absorption of Isoalantolactone and Alantolactone, Two Sesquiterpene Lactones from Radix Inulae, Using Caco-2 Cells. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 44 (2): (295-303). [PMID:30209793] [10.1007/s13318-018-0510-x] |
| 11. Danling Liang, Tianqiao Yong, Shaodan Chen, Yizhen Xie, Diling Chen, Xinxin Zhou, Dan Li, Muxia Li, Lu Su, Dan Zuo. (2018) Hypouricemic Effect of 2,5-Dihydroxyacetophenone, a Computational Screened Bioactive Compound from Ganoderma applanatum, on Hyperuricemic Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19 (5): (1394). [PMID:29735945] [10.3390/ijms19051394] |
| 12. Tianqiao Yong, Shaodan Chen, Yizhen Xie, Diling Chen, Jiyan Su, Ou Shuai, Huiping Hu, Dan Zuo, Danling Liang. (2018) Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2. AMERICAN JOURNAL OF CHINESE MEDICINE, 46 (3): (585-599). [PMID:29595077] [10.1142/S0192415X18500301] |
| 13. Hui Wang, Yukun Feng, Qian Wang, Xiucai Guo, Wenlin Huang, Ying Peng, Jiang Zheng. (2016) Cysteine-Based Protein Adduction by Epoxide-Derived Metabolite(s) of Benzbromarone. CHEMICAL RESEARCH IN TOXICOLOGY, 29 (12): (2145–2152). [PMID:27989145] [10.1021/acs.chemrestox.6b00275] |
| 14. Gao Hong-Xue, Liu Zhi-Qiang, Hou Zong, Song Feng-Rui, Xing Jun-Peng, Zheng Zhong, Liu Shu. (2024) Comprehensive Screening and Evaluation of Anti-gout Activity of Plantago asiatica L. through Integrated In vivo and In vitro Methodologies. World Journal of Traditional Chinese Medicine, (10.4103/wjtcm.wjtcm_75_24). [10.4103/wjtcm.wjtcm_75_24] |
| 15. Fengxin Zheng, Suiqing Mai, Xiaolin Cen, Pei Zhao, Wenjie Ye, Jiale Ke, Shiqin Lin, Huazhong Hu, Zitao Guo, Shuqin Zhang, Hui Liao, Ting Wu, Yuanxin Tian, Qun Zhang, Jianxin Pang, Zean Zhao. (2024) Discovery of digallic acid as XOD/URAT1 dual target inhibitor for the treatment of hyperuricemia. BIOORGANIC CHEMISTRY, 147 (107381). [PMID:38669781] [10.1016/j.bioorg.2024.107381] |
| 16. Hongxue Gao, Zhiqiang Liu, Fengrui Song, Junpeng Xing, Zhong Zheng, Zong Hou, Shu Liu. (2024) Establishment of Polydopamine-Modified HK-2 Cell Membrane Chromatography and Screening of Active Components from Plantago asiatica L.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (2): (1153). [PMID:38256226] [10.3390/ijms25021153] |
| 17. Jia-hong Liang, Xiao-lei Yi, Jia-min Gong, Zuo Du. (2024) Evaluation of the inhibitory effects of antigout drugs on human carboxylesterases in vitro. TOXICOLOGY IN VITRO, 98 (105833). [PMID:38670244] [10.1016/j.tiv.2024.105833] |
| 18. Yan Huang, Cantao Li, Wenjing Xu, Fenfen Li, Ying Hua, Changyu Xu, Chenxi Wu, Yihuan Wang, Xiaoxi Zhang, Daozong Xia. (2024) Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation. iScience, 27 (11): (111186). [PMID:39524334] [10.1016/j.isci.2024.111186] |
| 19. Wang Aiping, Ning Jie, Zhao Lu, Xu Renjie. (2024) Lipid-lowering effect and oral transport characteristics study of curculigoside. Frontiers in Cardiovascular Medicine, 11 [PMID:39015683] [10.3389/fcvm.2024.1426379] |
| 20. Lu Li, Kunlu Zhao, Jian Luo, Jinhong Tian, Fengxin Zheng, Xueman Lin, Zijun Xie, Heyang Jiang, Yongmei Li, Zean Zhao, Ting Wu, Jianxin Pang. (2024) Piperine Improves Hyperuricemic Nephropathy by Inhibiting URAT1/GLUT9 and the AKT-mTOR Pathway. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 72 (12): (6565-6574). [PMID:38498316] [10.1021/acs.jafc.3c07655] |
| 21. Yongmei Li, Fengxin Zheng, Shiqi Zhong, Kunlu Zhao, Hui Liao, Jiacheng Liang, Qiang Zheng, Huicong Wu, Shifan Zhang, Ying Cao, Ting Wu, Jianxin Pang. (2024) Protecting against ferroptosis in hyperuricemic nephropathy: The potential of ferrostatin-1 and its inhibitory effect on URAT1. EUROPEAN JOURNAL OF PHARMACOLOGY, (176528). [PMID:38556118] [10.1016/j.ejphar.2024.176528] |