溴丙酮酸 (3-BP)

己糖激酶II抑制剂。抗肿瘤剂。

2篇引用文献

COA

级别和纯度:

≥96%

CAS编号: 1113-59-3
分子式: C₃H₃BrO₃
分子量: 166.96
Beilstein号: 1746786
EC号: 214-206-5
MDL号: MFCD00002587
PubChem编号: 70684
PubChem SID: 504754555

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货号 (SKU)	包装规格	是否现货
B120321-5g	5g	现货
B120321-25g	25g	现货
B120321-100g	100g	期货

查看相关系列

Apoptosis (7108) Autophagy (2848) Glucose Metabolism (3713) Metabolic Enzyme/Protease (4889) 己糖激酶 (9) 羧酸 (2181) 非杂环砌块 (8221)

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基本描述

别名	3-溴丙酮酸
英文别名	AS-16146 \| B1153 \| 3-bromopyruvic acid \| bromo-2-oxopropanoic acid \| bromopyruvic acid \| Bromopyruvic acid, >=97.0% (T) \| J-650255 \| 3-bromopyruvate \| BPV \| J-511892 \| 3-bromo-2-oxopropanoic acid \| AKOS015892643 \| AM84337 \| EINECS 214-206-5 \| 3-BP \| 3-BrP
规格或纯度	≥96%
英文名称	Bromopyruvic acid (3-BP)
生化机理	己糖激酶II抑制剂。抗肿瘤剂。抑制谷胱甘肽S-转移酶和SOD。丙酮酸衍生物。引起氧化应激。诱导S和G2 / M细胞周期停滞。显示出抗增殖作用。显示抗肿瘤和抗菌
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	3-Bromopyruvic acid is a brominated derivative of pyruvic acid , which inhibits HXK II (hexokinase II) in cancer cells. As a result of this inhibition the cells are unable to metabolize glucose into ATP directly. Studies conducted on MCF-7 breast cancer cells show that 3-Bromopyruvic acid hydrate reduces the expression of Bcl-2, c-Myc and mutant p53, which are involved in the cell death signal transduction pathway. Alternate studies indicate that 3-Bromopyruvic acid hydrate is a very selective antibiotic, inhibiting the growth of certain yeasts. Affinity label for cysteine residues; Cross-linker between nucleic acids and proteins
纯度	≥96%

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)

点击查看靶蛋白信息： Hdac6

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

dapA Dihydrodipicolinate synthase (65 活性数据)

点击查看靶蛋白信息： dapA

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

icl1 Isocitrate lyase 1 (45 活性数据)

点击查看靶蛋白信息： icl1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504754555
EC号	214-206-5
分子类型	小分子
IIUPAC Name	3-bromo-2-oxopropanoic acid
INCHI	1S/C3H3BrO3/c4-1-2(5)3(6)7/h1H2,(H,6,7)
InChi Key	PRRZDZJYSJLDBS-UHFFFAOYSA-N
Smiles	C(C(=O)C(=O)O)Br
Isomeric SMILES	C(C(=O)C(=O)O)Br
分子量	166.96
Beilstein号	1746786
Reaxy-Rn	1746786
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1746786&ln=

化学和物理性质

敏感性	对空气敏感、吸湿、对热敏感
熔点	77°C
分子量	166.960 g/mol
XLogP3	0.500
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	3
可旋转键计数Rotatable Bond Count	2
精确质量Exact Mass	165.927 Da
单同位素质量Monoisotopic Mass	165.927 Da
拓扑极表面积Topological Polar Surface Area	54.400 Å²
重原子数Heavy Atom Count	7
形式电荷Formal Charge	0
复杂度Complexity	98.400
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS05
信号词	危险
危险声明	H314: 造成严重的皮肤灼伤和眼睛损伤
预防措施声明	P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P310: 立即致电解毒中心或医生。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
WGK Germany	3
RTECS	UZ0840000
个人防护装备	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到8个结果

批号(Lot Number)	证书类型	货号
H2518235	分析证书	B120321
H2518236	分析证书	B120321
H2518237	分析证书	B120321
B2314236	分析证书	B120321
B2314297	分析证书	B120321
B2314283	分析证书	B120321
B2314235	分析证书	B120321
I2412072	分析证书	B120321

此产品的引用文献

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引用文献

1. I Kameshita,M Tokushige,K Izui,H Katsuki. (1979-11-01) Phosphoenolpyruvate carboxylase of Escherichia coli. Affinity labeling with bromopyruvate.. Journal of biochemistry, 86 ((5)): (1251-1257). [PMID:42643]
2. N Nitta,O Kuge,S Yui,A Tsugawa,K Negishi,H Hayatsu. (1984-01-23) A new reaction useful for chemical cross-linking between nucleic acids and proteins.. FEBS letters, 166 ((1)): (194-198). [PMID:6692920]
3. M H Wang,Z X Wang,K Y Zhao. (1996-11-15) Kinetics of inactivation of bovine pancreatic ribonuclease A by bromopyruvic acid.. The Biochemical journal, 320 (( Pt 1)): (187-192). [PMID:8947485]
4. Ananda Herath,Russell Dahl,Nicholas D P Cosford. (2009-12-30) Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles.. Organic letters, 12 ((3)): (412-415). [PMID:20038130]
5. Magdalena Davidescu,Miriam Sciaccaluga,Lara Macchioni,Roberto Angelini,Patrizia Lopalco,Maria Grazia Rambotti,Rita Roberti,Angela Corcelli,Emilia Castigli,Lanfranco Corazzi. (2012-02-10) Bromopyruvate mediates autophagy and cardiolipin degradation to monolyso-cardiolipin in GL15 glioblastoma cells.. Journal of bioenergetics and biomembranes, 44 ((1)): (51-60). [PMID:22318357]
6. Harrie A Verhoeven,Leo J L D van Griensven. (2012-02-10) Flow cytometric evaluation of the effects of 3-bromopyruvate (3BP) and dichloracetate (DCA) on THP-1 cells: a multiparameter analysis.. Journal of bioenergetics and biomembranes, 44 ((1)): (91-99). [PMID:22318358]
7. Clara Rodrigues-Ferreira,Ana Paula Pereira da Silva,Antonio Galina. (2012-02-11) Effect of the antitumoral alkylating agent 3-bromopyruvate on mitochondrial respiration: role of mitochondrially bound hexokinase.. Journal of bioenergetics and biomembranes, 44 ((1)): (39-49). [PMID:22322891]
8. Su Jong Yu,Jung-Hwan Yoon,Jong-In Yang,Eun Ju Cho,Min Sun Kwak,Eun Sun Jang,Jeong-Hoon Lee,Yoon Jun Kim,Hyo-Suk Lee,Chung Yong Kim. (2012-02-22) Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition.. Journal of bioenergetics and biomembranes, 44 ((1)): (101-115). [PMID:22350012]
9. Odília Queirós,Ana Preto,António Pacheco,Céline Pinheiro,João Azevedo-Silva,Roxana Moreira,Madalena Pedro,Young H Ko,Peter L Pedersen,Fátima Baltazar,Margarida Casal. (2012-02-22) Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate.. Journal of bioenergetics and biomembranes, 44 ((1)): (141-153). [PMID:22350013]
10. Shanmugasundaram Ganapathy-Kanniappan,Rani Kunjithapatham,Michael S Torbenson,Pramod P Rao,Kathryn A Carson,Manon Buijs,Mustafa Vali,Jean-François H Geschwind. (2012-02-24) Human hepatocellular carcinoma in a mouse model: assessment of tumor response to percutaneous ablation by using glyceraldehyde-3-phosphate dehydrogenase antagonists.. Radiology, 262 ((3)): (834-845). [PMID:22357885]
11. Paweł Lis,Marek Zarzycki,Young H Ko,Margarida Casal,Peter L Pedersen,Andre Goffeau,Stanisław Ułaszewski. (2012-02-24) Transport and cytotoxicity of the anticancer drug 3-bromopyruvate in the yeast Saccharomyces cerevisiae.. Journal of bioenergetics and biomembranes, 44 ((1)): (155-161). [PMID:22359102]
12. S M El Sayed,R M Abou El-Magd,Y Shishido,K Yorita,S P Chung,D H Tran,T Sakai,H Watanabe,S Kagami,K Fukui. (2012-07-18) D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects.. Journal of bioenergetics and biomembranes, 44 ((5)): (513-523). [PMID:22802136]
13. My Wintzell,Lina Löfstedt,Joel Johansson,Anne B Pedersen,Jonas Fuxe,Maria Shoshan. (2012-09-08) Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate.. Cancer biology & therapy, 13 ((14)): (1454-1462). [PMID:22954696]
14. Huijie Xiao,Shasha Li,Dapeng Zhang,Tongjun Liu,Ming Yu,Feng Wang. (2012-10-19) Separate and concurrent use of 2-deoxy-D-glucose and 3-bromopyruvate in pancreatic cancer cells.. Oncology reports, 29 ((1)): (329-334). [PMID:23076497]
15. Mariusz Dyląg,Paweł Lis,Katarzyna Niedźwiecka,Young H Ko,Peter L Pedersen,Andre Goffeau,Stanisław Ułaszewski. (2013-04-02) 3-Bromopyruvate: a novel antifungal agent against the human pathogen Cryptococcus neoformans.. Biochemical and biophysical research communications, 434 ((2)): (322-327). [PMID:23541578]
16. Adam D Lietzan,Martin St Maurice. (2013-10-26) Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs.. Biochemical and biophysical research communications, 441 ((2)): (377-382). [PMID:24157795]
17. Kathryn Wilsterman,Aimee Pepper,George E Bentley. (2017-11-04) Low glucose availability stimulates progesterone production by mouse ovaries in vitro.. The Journal of experimental biology, 220 ((Pt 24)): (4583-4588). [PMID:29097592]
18. Filipa Lopes-Coelho,Carolina Nunes,Sofia Gouveia-Fernandes,Rita Rosas,Fernanda Silva,Paula Gameiro,Tânia Carvalho,Maria Gomes da Silva,José Cabeçadas,Sérgio Dias,Luís G Gonçalves,Jacinta Serpa. (2017-11-16) Monocarboxylate transporter 1 (MCT1), a tool to stratify acute myeloid leukemia (AML) patients and a vehicle to kill cancer cells.. Oncotarget, 8 ((47)): (82803-82823). [PMID:29137304]
19. Paul K Ziegler,Julia Bollrath,Charles K Pallangyo,Takaji Matsutani,Özge Canli,Tiago De Oliveira,Michaela A Diamanti,Nina Müller,Jaba Gamrekelashvili,Tracy Putoczki,David Horst,Arun K Mankan,Meryem G Öner,Susanna Müller,Josef Müller-Höcker,Thomas Kirchner,Julia Slotta-Huspenina,M Mark Taketo,Thomas Reinheckel,Stefan Dröse,Andrew C Larner,Winfried S Wels,Matthias Ernst,Tim F Greten,Melek C Arkan,Thomas Korn,Dagmar Wirth,Florian R Greten. (2018-06-19) Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.. Cell, 174 ((1)): (88-101). [PMID:29909986]
20. Alessio Bocedi,Giada Cattani,Claudia Martelli,Flora Cozzolino,Massimo Castagnola,Pietro Pucci,Giorgio Ricci. (2018-10-31) The extreme hyper-reactivity of Cys94 in lysozyme avoids its amorphous aggregation.. Scientific reports, 8 ((1)): (16050-16050). [PMID:30375487]
21. Aleksandra Agapova,Agnese Serafini,Michael Petridis,Debbie M Hunt,Acely Garza-Garcia,Charles D Sohaskey,Luiz Pedro Sório de Carvalho. (2019-02-01) Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis.. eLife, 8 [PMID:30702426]
22. Jing Yong,Helmut Bischof,Sandra Burgstaller,Marina Siirin,Anne Murphy,Roland Malli,Randal J Kaufman. (2019-09-10) Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2.. eLife, 8 [PMID:31498082]
23. Jie Liu,Wang Wang,Lei Wang,Xian-Mei Qi,Yu-Hui Sha,Ting Yang. (2020-01-11) 3-Bromopyruvate alleviates the development of monocrotaline-induced rat pulmonary arterial hypertension by decreasing aerobic glycolysis, inducing apoptosis, and suppressing inflammation.. Chinese medical journal, 133 ((1)): (49-60). [PMID:31923104]
24. Shigemi Sasawatari,Yuki Okamoto,Atsushi Kumanogoh,Toshihiko Toyofuku. (2020-01-24) Blockade of N-Glycosylation Promotes Antitumor Immune Response of T Cells.. Journal of immunology (Baltimore, Md. : 1950), 204 ((5)): (1373-1385). [PMID:31969386]
25. Mina Choi,Yeong Min Choi,Soo-Young Choi,In-Sook An,Seunghee Bae,Sungkwan An,Jin Hyuk Jung. (2020-03-19) Glucose metabolism regulates expression of hair-inductive genes of dermal papilla spheres via histone acetylation.. Scientific reports, 10 ((1)): (4887-4887). [PMID:32184439]
26. Fengsen Duan,Chunlei Mei,Luhao Yang,Junyan Zheng,Huiai Lu,Yanzhi Xia,Stacy Hsu,Huageng Liang,Ling Hong. (2020-05-10) Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells.. Scientific reports, 10 ((1)): (7714-7714). [PMID:32382009]
27. Alessio Bocedi,Giorgia Gambardella,Giada Cattani,Simonetta Bartolucci,Danila Limauro,Emilia Pedone,Federica Iavarone,Massimo Castagnola,Giorgio Ricci. (2020-06-04) Ultra-rapid glutathionylation of chymotrypsinogen in its molten globule-like conformation: A comparison to archaeal proteins.. Scientific reports, 10 ((1)): (8943-8943). [PMID:32488029]
28. Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M Metelo, Michelle L Kelley, Surendra Punganuru, Kyung Bo Kim, Benjamin Olenchock, Eugene Rhee, Andrew M Intlekofer, Othon Iliopoulos, Edward Chouchani, Jing-Ruey Joanna Yeh,. (2020-07-12) Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction.. Cancer research, 80 ((17)): ( 3492-3506 ). [PMID:32651261]
29. Sho Ikeda,Fumito Abe,Yuka Matsuda,Akihiro Kitadate,Naoto Takahashi,Hiroyuki Tagawa. (2020-08-14) Hypoxia-inducible hexokinase-2 enhances anti-apoptotic function via activating autophagy in multiple myeloma.. Cancer science, 111 ((11)): (4088-4101). [PMID:32790954]
30. Stephanie Spannl,Tomasz Buhl,Ioannis Nellas,Salma A Zeidan,K Venkatesan Iyer,Helena Khaliullina,Carsten Schultz,André Nadler,Natalie A Dye,Suzanne Eaton. (2020-10-07) Glycolysis regulates Hedgehog signalling via the plasma membrane potential.. The EMBO journal, 39 ((21)): (e101767-e101767). [PMID:33021744]
31. Jia Sun,Xiaozhong Huang,Chao Niu,Xuejiao Wang,Wanqian Li,Mengxue Liu,Ying Wang,Shuai Huang,Xixi Chen,Xiaokun Li,Yang Wang,Litai Jin,Jian Xiao,Weitao Cong. (2020-12-29) aFGF alleviates diabetic endothelial dysfunction by decreasing oxidative stress via Wnt/β-catenin-mediated upregulation of HXK2.. Redox biology, 39 (101811-101811). [PMID:33360774]
32. Karl Kochanowski,Timur Sander,Hannes Link,Jeremy Chang,Steven J Altschuler,Lani F Wu. (2021-01-21) Systematic alteration of in\xa0vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes.. Cell reports, 34 ((3)): (108647-108647). [PMID:33472066]
33. Ksenija Radic Shechter,Eleni Kafkia,Katharina Zirngibl,Sylwia Gawrzak,Ashna Alladin,Daniel Machado,Christian Lüchtenborg,Daniel C Sévin,Britta Brügger,Kiran R Patil,Martin Jechlinger. (2021-10-26) Metabolic memory underlying minimal residual disease in breast cancer.. Molecular systems biology, 17 ((10)): (e10141-e10141). [PMID:34694069]
34. Philippe Icard,Icard Philippe,Xiao-Dong Zhang,Zhang Xiao-Dong,Edwige Lemoisson,Lemoisson Edwige,Marie-Hélène Louis,Louis Marie-Hélène,Stéphane Allouche,Allouche Stéphane,Hubert Lincet,Lincet Hubert,Laurent Poulain,Poulain Laurent. (2012-02-11) Experimental results using 3-bromopyruvate in mesothelioma: in vitro and in vivo studies.. Journal of bioenergetics and biomembranes, 44 ((1)): (81-90). [PMID:22322892]
35. Simone Cardaci,Enrico Desideri,Maria Rosa Ciriolo. (2012-02-14) Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug.. Journal of bioenergetics and biomembranes, 44 ((1)): (17-29). [PMID:22328057]
36. Douglas Jardim-Messeder,Juliana Camacho-Pereira,Antonio Galina. (2012-02-22) 3-Bromopyruvate inhibits calcium uptake by sarcoplasmic reticulum vesicles but not SERCA ATP hydrolysis activity.. The international journal of biochemistry & cell biology, 44 ((5)): (801-807). [PMID:22343412]
37. Alvaro Marín-Hernández,Juan Carlos Gallardo-Pérez,Sayra Y López-Ramírez,Jorge Donato García-García,José Salud Rodríguez-Zavala,Lena Ruiz-Ramírez,Isabel Gracia-Mora,Alejandro Zentella-Dehesa,Marcela Sosa-Garrocho,Marina Macías-Silva,Rafael Moreno-Sánchez,Sara Rodríguez-Enríquez. (2012-02-22) Casiopeina II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation.. Archives of toxicology, 86 ((5)): (753-766). [PMID:22349057]
38. Zhenjie Tang,Shuqiang Yuan,Yumin Hu,Hui Zhang,Wenjing Wu,Zhaolei Zeng,Jing Yang,Jingping Yun,Ruihua Xu,Peng Huang. (2012-02-22) Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-bromopyruvate propyl ester.. Journal of bioenergetics and biomembranes, 44 ((1)): (117-125). [PMID:22350014]
39. S Nahum Goldberg. (2012-02-24) Science to practice: what do molecular biologic studies in rodent models add to our understanding of interventional oncologic procedures including percutaneous ablation by using glyceraldehyde-3-phosphate dehydrogenase antagonists?. Radiology, 262 ((3)): (737-739). [PMID:22357877]
40. Qi Zhang,Jing Pan,Paula E North,Shoua Yang,Ronald A Lubet,Yian Wang,Ming You. (2012-03-10) Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity.. Cancer prevention research (Philadelphia, Pa.), 5 ((5)): (717-725). [PMID:22401980]
41. Simone Cardaci,Salvatore Rizza,Giuseppe Filomeni,Roberta Bernardini,Fabio Bertocchi,Maurizio Mattei,Maurizio Paci,Giuseppe Rotilio,Maria Rosa Ciriolo. (2012-07-10) Glutamine deprivation enhances antitumor activity of 3-bromopyruvate through the stabilization of monocarboxylate transporter-1.. Cancer research, 72 ((17)): (4526-4536). [PMID:22773663]
42. Kohei Matsushita,Keiichi Uchida,Susumu Saigusa,Shozo Ide,Kiyoshi Hashimoto,Yuki Koike,Kohei Otake,Mikihiro Inoue,Koji Tanaka,Masato Kusunoki. (2012-07-21) Glycolysis inhibitors as a potential therapeutic option to treat aggressive neuroblastoma expressing GLUT1.. Journal of pediatric surgery, 47 ((7)): (1323-1330). [PMID:22813791]
43. Kivanç Birsoy,Tim Wang,Richard Possemato,Omer H Yilmaz,Catherine E Koch,Walter W Chen,Amanda W Hutchins,Yetis Gultekin,Tim R Peterson,Jan E Carette,Thijn R Brummelkamp,Clary B Clish,David M Sabatini. (2012-12-04) MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors.. Nature genetics, 45 ((1)): (104-108). [PMID:23202129]
44. Shanmugasundaram Ganapathy-Kanniappan,Rani Kunjithapatham,Jean-Francois Geschwind. (2012-12-26) Anticancer efficacy of the metabolic blocker 3-bromopyruvate: specific molecular targeting.. Anticancer research, 33 ((1)): (13-20). [PMID:23267123]
45. Michael A Lea,Mehreen S Qureshi,Michael Buxhoeveden,Nicolette Gengel,Jessica Kleinschmit,Charles Desbordes. (2013-02-09) Regulation of the proliferation of colon cancer cells by compounds that affect glycolysis, including 3-bromopyruvate, 2-deoxyglucose and biguanides.. Anticancer research, 33 ((2)): (401-407). [PMID:23393330]
46. Eva Calviño,María Cristina Estañ,Carlos Sánchez-Martín,Rocío Brea,Elena de Blas,María del Carmen Boyano-Adánez,Eduardo Rial,Patricio Aller. (2013-12-07) Regulation of death induction and chemosensitizing action of 3-bromopyruvate in myeloid leukemia cells: energy depletion, oxidative stress, and protein kinase activity modulation.. The Journal of pharmacology and experimental therapeutics, 348 ((2)): (324-335). [PMID:24307199]
47. Orkhan Isayev,Vanessa Rausch,Nathalie Bauer,Li Liu,Pei Fan,Yiyao Zhang,Jury Gladkich,Clifford C Nwaeburu,Jürgen Mattern,Martin Mollenhauer,Felix Rückert,Sebastian Zach,Uwe Haberkorn,Wolfgang Gross,Frank Schönsiegel,Alexandr V Bazhin,Ingrid Herr. (2014-07-13) Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine.. Oncotarget, 5 ((13)): (5177-5189). [PMID:25015789]
48. Maria V Liberti,Ziwei Dai,Suzanne E Wardell,Joshua A Baccile,Xiaojing Liu,Xia Gao,Robert Baldi,Mahya Mehrmohamadi,Marc O Johnson,Neel S Madhukar,Alexander A Shestov,Iok I Christine Chio,Olivier Elemento,Jeffrey C Rathmell,Frank C Schroeder,Donald P McDonnell,Jason W Locasale. (2017-09-19) A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.. Cell metabolism, 26 ((4)): (648-659). [PMID:28918937]
49. Lin Jiao,Hai-Liang Zhang,Dan-Dan Li,Ke-Li Yang,Jun Tang,Xuan Li,Jiao Ji,Yan Yu,Rui-Yan Wu,Senthilkumar Ravichandran,Jian-Jun Liu,Gong-Kan Feng,Min-Shan Chen,Yi-Xin Zeng,Rong Deng,Xiao-Feng Zhu. (2017-10-06) Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2).. Autophagy, 14 ((4)): (671-684). [PMID:28980855]
50. Natalia Pieńkowska,Grzegorz Bartosz,Paulina Furdak,Izabela Sadowska-Bartosz. (2021-01-16) Delphinidin Increases the Sensitivity of Ovarian Cancer Cell Lines to 3-Bromopyruvate.. International journal of molecular sciences, 22 ((2)): [PMID:33445795]
51. Xuan Meng, Lin Wang, Ning Zhao, Delong Zhao, Yongli Shen, Yuan Yao, Wenjie Jing, Shuli Man, Yujie Dai, Yanjun Zhao. (2023) Stimuli-responsive cancer nanomedicines inhibit glycolysis and impair redox homeostasis. Acta Biomaterialia, 167 (374). [PMID:37343908] [10.1016/j.actbio.2023.06.016]
52. Yongli Shen, Lin Wang, Binglong Ji, Xinlei Lu, Delong Zhao, Yujie Dai, Xuan Meng. (2024) Stimulus-responsive nanomedicine mediated by metabolic intervention mechanisms to amplify redox anticancer therapy. CHEMICAL ENGINEERING JOURNAL, 486 (150130). [10.1016/j.cej.2024.150130]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

溴丙酮酸 (3-BP)

库存信息

库存信息

库存信息

基本描述

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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