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Recombinant CD98 Antibody (Biotin)

Recombinant CD98 Antibody (Biotin)

COA

级别和纯度:

已验证

ExactAb™

0.5 mg/mL

应用:

Flow Cytometry

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
亚型: Human IgG1
偶联: Biotin

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
Ab215361-10μg	10μg	现货
Ab215361-25μg	25μg	现货
Ab215361-100μg	100μg	现货

查看相关系列

点击查看靶蛋白信息: SLC3A2

4F2 (7) 4F2HC (7) 4T2HC (7) Accession#:P08195 (9) CD98 (9) CD98HC (7) Gene ID:6520 (9) MDU1 (7) NACAE (7) SLC3A2 (9)

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基本信息

产品名称	Recombinant CD98 Antibody (Biotin)
别名	CD98抗体
英文别名	4F2 antibody \| 4F2 cell surface antigen heavy chain antibody \| 4F2 cell-surface antigen heavy chain antibody \| 4F2 heavy chain antibody \| 4F2 heavy chain antigen antibody \| 4F2_HUMAN antibody \| 4F2hc antibody \| 4T2HC antibody \| Antigen defined by monoclon
规格或纯度	ExactAb™, 已验证, 0.5 mg/mL
生化机理	Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. Post-translational: Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions.
宿主种属	小鼠(Mouse)
特异性	SLC3A2
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
阳性对照	Flow Cytometry: MCF-7
偶联	Biotin

产品属性

克隆类型	重组抗体
Format	Whole IgG
轻链亚型	kappa
纯化方法	Protein A purified
储存缓冲液	Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.
防腐剂	0.05% Proclin300
浓度	0.5 mg/mL
储存温度	2-8°C储存,避光,禁止冷冻
运输条件	冰袋运输
稳定性与储存	The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
分子类型	抗体

关联靶点（人）

SLC3A2 Tbio 4F2 细胞表面抗原重链(4F2 cell-surface antigen heavy chain) (0 活性数据)

点击查看靶蛋白信息： SLC3A2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

图片

Flow Cytometry: Recombinant CD98 Antibody (Biotin) (Ab215361)

Recombinant CD98 Antibody (Biotin) (Ab215361) - Flow Cytometry
Flow cytometry analysis of CD98 expression by MCF-7 cells (red) compared to an isotype control (blue). Cells were stained with Recombinant CD98 Antibody (Biotin) (Ab215361) at 0.1μg/test for 1 hour at 4°C. Then incubated with Recombinant Streptavidin Protein (R-PE) (rp156150) at 0.1μg/test for 30 minutes at 4°C in the dark. Blue - Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

应用

应用名称	稀释比例
Flow Cytometry	≤1.0μg/ test For flow cytometric staining, the suggested use of this reagent is ≤1.0 μg per million cells in 100 µL staining volume.