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Recombinant TCR γ/δ Antibody

Recombinant TCR γ/δ Antibody

级别和纯度:

≥95%(SDS-PAGE)
见COA

应用:

ELISA
Flow Cytometry

宿主种属: 小鼠(Mouse)
种属反应性: 人(Human)
亚型: Mouse IgG1
克隆号: P22D01
偶联: Unconjugated

有货

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货号 (SKU)	包装规格	是否现货
Ab212161-10μg	10μg	现货
Ab212161-50μg	50μg	现货
Ab212161-100μg	100μg	现货
Ab212161-1mg	1mg	期货

查看相关系列

点击查看靶蛋白信息: TRDC 点击查看靶蛋白信息: TRGC2

Accession#: B7Z8K6 (4) Accession#: P03986 (4) Gene ID: 6964 (4) Gene ID: 6965 (4) TCR γ/δ (4) TRGC2/ TRDC (1)

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基本信息

产品名称	Recombinant TCR γ/δ Antibody
别名	γ/δ T细胞受体 \| TCR γ/δ抗体 \| TCR gamma/delta抗体
英文别名	CD_antigen=CD3d antibody \| CD3D antibody \| CD3G antibody \| T cell antigen receptor delta polypeptide antibody \| T cell antigen receptor gamma polypeptide antibody \| T cell rearranging gene gamma antibody \| T cell receptor delta antibody \| T cell receptor
规格或纯度	无动物源, 无载体, 重组, ExactAb™, 无叠氮钠, 已验证, 高性能, ≥95%(SDS-PAGE), 见COA
生化机理	Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair. Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells. Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements.
宿主种属	小鼠(Mouse)
特异性	Human TCR γ/δ
种属反应性	人(Human)
阳性对照	Flow Cytometry: Human peripheral blood lymphocytes
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
储存缓冲液	PBS, pH 7.4
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
分子类型	抗体

关联靶点（人）

TRDC Tdark T 细胞受体δ常数(T cell receptor delta constant) (0 活性数据)

点击查看靶蛋白信息： TRDC

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

TRGC2 Tdark T 细胞受体伽马常数 2(T cell receptor gamma constant 2) (0 活性数据)

点击查看靶蛋白信息： TRGC2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

图片

Flow Cytometry: Recombinant TCR γ/δ Antibody (Ab212161)

Recombinant TCR γ/δ Antibody (Ab212161) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling TCR γ/δ with Recombinant TCR γ/δ Antibody (Ab212161) conjugated with biotin (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with mouse IgG (Ab180306) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Recombinant TCR γ/δ Antibody (Ab212161)

Recombinant TCR γ/δ Antibody (Ab212161) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling TCR γ/δ (red) with Recombinant TCR γ/δ Antibody (Ab212161) conjugated with biotin at 0.2 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Isotype control, mouse IgG (Ab180306) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.