基本信息

产品名称	Recombinant CD11b Antibody
别名	CD11抗原样家族成员B \| 整合素alpha M（ITGAM） \| 整合素α M单克隆抗体 \| ITGAM 抗体 \| Anti-CD11b抗体 \| CD11b抗体 \| CD11b单抗
英文别名	antigen CD11b (p170) \| CD11 antigen-like family member B \| CD11b antigen \| CD11b \| Cell surface glycoprotein MAC-1 subunit alpha \| Complement component 3 receptor 3 subunit \| Mo1, alpha subunit antibody \| MO1A antibody \| Neutrophil adherence receptor alph
规格或纯度	无动物源, 无载体, 重组, ExactAb™, 无叠氮钠, 已验证, 高性能, ≥95%(SDS-PAGE), 见COA
生化机理	Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038)..
宿主种属	大鼠(Rat)
特异性	CD11b
种属反应性	人(Human),小鼠(Mouse)
免疫原	C57BL/10 splenocytes
阳性对照	Flow Cytometry: Human peripheral blood monocyte
偶联	Unconjugated
备注	此产品可替代 Ab093718

产品属性

克隆类型	重组抗体
Format	Whole IgG
轻链亚型	kappa
SDS-PAGE	150.0 KDa
纯化方法	Protein A purified
储存缓冲液	PBS, pH 7.4
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
分子类型	抗体

关联靶点（人）

ITGAM Tbio 整合素α-M(Integrin alpha-M) (0 活性数据)

点击查看靶蛋白信息： ITGAM

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Recombinant CD11b Antibody (Ab210604)

Recombinant CD11b Antibody (Ab210604) - Flow Cytometry
Flow Cytometry analysis of mouse bone marrow cells labelling CD11b with Recombinant CD11b Antibody (Ab210604) conjugated with biotin (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with Rat IgG Isotype Control Antibody (Biotin) (Ab180310) (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Recombinant CD11b Antibody (Ab210604)

Recombinant CD11b Antibody (Ab210604) - Flow Cytometry
Flow Cytometry analysis of mouse bone marrow cells labelling CD11b (red) with Recombinant CD11b Antibody (Ab210604) conjugated with biotin at 0.2 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Rat IgG Isotype Control Antibody (Biotin) (Ab180310). Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Recombinant CD11b Antibody (Ab210604)

Recombinant CD11b Antibody (Ab210604) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD11b with Recombinant CD11b Antibody (Ab210604) conjugated with biotin (right panel) at 0.2 μg/mL for 1 hour at 4°C, compared with rat IgG (Ab180310) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Flow Cytometry: Recombinant CD11b Antibody (Ab210604)

Recombinant CD11b Antibody (Ab210604) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD11b (red) with Recombinant CD11b Antibody (Ab210604) conjugated with biotin at 0.2 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Isotype control, rat IgG (Ab180310) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.