AR20.5 (anti-MUC1)

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
亚型: Human IgG1
偶联: Unconjugated

有货

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货号 (SKU)	包装规格	是否现货
Ab209792-100μg	100μg	现货
Ab209792-1mg	1mg	现货
Ab209792-5mg	5mg	现货
Ab209792-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: MUC1

Accession#:P15941 (22) CD227 (12) Gene ID:4582 (22) MUC1 (22)

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基本信息

产品名称	AR20.5 (anti-MUC1)
别名	MUC1抗体 \| MUC1单克隆抗体 \| MUC1药靶抗体
英文别名	ADMCKD antibody \| ADMCKD1 antibody \| Breast carcinoma associated antigen DF3 antibody \| Breast carcinoma-associated antigen DF3 antibody \| CA 15-3 antibody \| CA15 3 antibody \| CA15 3 antigen antibody \| CA15-3 antibody \| CA15.3 antibody \| Cancer antigen 15
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理	The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
宿主种属	人(Human)
特异性	MUC1
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
分子类型	抗体

关联靶点（人）

MUC1 Tchem 黏蛋白-1(Mucin-1) (0 活性数据)

点击查看靶蛋白信息： MUC1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

图片

Flow Cytometry: AR20.5 (anti-MUC1) (Ab209792)

AR20.5 (anti-MUC1) (Ab209792) - Flow Cytometry
Flow Cytometry analysis of H_MUC1(CD227) HEK293 cells labelling MUC1 at 1×105 cell/well can bind AR20.5 (anti-MUC1) (Ab209792), with the EC50 is 0.110 nM.