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Anrukinzumab (anti-IL-13), 白细胞介素-13 抑制剂

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
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货号 (SKU) 包装规格 是否现货 价格 数量
Ab179373-100μg
100μg 现货 Stock Image
Ab179373-1mg
1mg 现货 Stock Image
Ab179373-5mg
5mg 现货 Stock Image
Ab179373-10mg
10mg 期货 Stock Image

基本信息

产品名称 Anrukinzumab (anti-IL-13), 白细胞介素-13 抑制剂
别名 安芦组单抗 | 安鲁金珠单抗(抗 IL-13)
英文别名 Allergic rhinitis antibody | ALRH antibody | BHR 1 antibody | BHR1 antibody | Bronchial hyperresponsiveness 1 (bronchial asthma) antibody | IL 13 antibody | IL-13 antibody | Il13 antibody | IL13_HUMAN antibody | Interleukin 13 antibody | Interleukin-13 an
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 IL13
种属反应性 人(Human),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated
作用类型 抑制剂
作用机制 白细胞介素-13 抑制剂

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 145.38 kDa
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 910649-32-0
分子类型 抗体

关联靶点(人)

IL13 Tclin 白细胞介素-13(Interleukin-13) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

图片

Anrukinzumab (anti-IL-13) (Ab179373) - ELISA
Immobilized Recombinant Human IL-13 Protein (rp147396) at 2.0 μg/mL can bind Anrukinzumab (anti-IL-13) (Ab179373) with the EC50 of 357.7 ng/mL.


Anrukinzumab (anti-IL-13) (Ab179373) - SEC
The purity of Anrukinzumab (anti-IL-13) (Ab179373) is more than 95% verified by HPLC.

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到3个结果

批号(Lot Number) 证书类型 货号
ZJ24F0404197 分析证书 Ab179373
ZJ24F0404198 分析证书 Ab179373
ZJ24F0404199 分析证书 Ab179373

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引用文献

1. Morgan, J G JG, Dolganov, G M GM, Robbins, S E SE, Hinton, L M LM and Lovett, M M..  (1992)  The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes..  Nucleic acids research,  (11): [PMID:1408833]
2. Smirnov, D V DV, Smirnova, M G MG, Korobko, V G VG and Frolova, E I EI..  (1995)  Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization..  Gene,  (3): [PMID:7721105]
3. Defrance, T T and 6 more authors..  (1994)  Interleukin 13 is a B cell stimulating factor..  The Journal of experimental medicine,  (1): [PMID:7903680]
4. Minty, A A and 9 more authors..  (1993)  Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses..  Nature,  (18): [PMID:8096327]
5. McKenzie, A N AN and 9 more authors..  (1993)  Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function..  Proceedings of the National Academy of Sciences of the United States of America,  (15): [PMID:8097324]
6. Dolganov, G G and 8 more authors..  (1996)  Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31..  Blood,  (15): [PMID:8605348]
7. Miloux, B B and 6 more authors..  (1997)  Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex..  FEBS letters,  (20): [PMID:9013879]
8. Heinzmann, A A and 31 more authors..  (2000)  Genetic variants of IL-13 signalling and human asthma and atopy..  Human molecular genetics,  (1): [PMID:10699178]
9. Moy, F J FJ, Diblasio, E E, Wilhelm, J J and Powers, R R..  (2001)  Solution structure of human IL-13 and implication for receptor binding..  Journal of molecular biology,  (29): [PMID:11419948]
10. Howard, T D TD and 8 more authors..  (2001)  Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population..  American journal of respiratory cell and molecular biology,  [PMID:11588017]
11. Wang, Min M and 7 more authors..  (2003)  A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis..  Human genetics,  [PMID:12928861]
12. Lupardus, Patrick J PJ, Birnbaum, Michael E ME and Garcia, K Christopher KC..  (2010)  Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2..  Structure (London, England : 1993),  (10): [PMID:20223216]
13. Kasaian, Marion T MT and 6 more authors..  (2011)  IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2..  Journal of immunology (Baltimore, Md. : 1950),  (1): [PMID:21622864]

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