Quetmolimab (anti-CX3CL1), Fractalkine 抑制剂

COA

级别和纯度:

≥95%(SDS-PAGE&SEC-HPLC)
见COA

应用:

Animal Model
ELISA
Flow Cytometry
Functional Assay

宿主种属: 人(Human)
种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
亚型: Human IgG2
偶联: Unconjugated

有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭

货号 (SKU)	包装规格	是否现货
Ab177929-100μg	100μg	现货
Ab177929-1mg	1mg	现货
Ab177929-5mg	5mg	现货
Ab177929-10mg	10mg	期货

查看相关系列

点击查看靶蛋白信息: CX3CL1

Accession#:P78423 (2) Class A GPCR (8201) CX3CL1 (2) Gene ID:6376 (2)

Skip to the end of the images gallery

Skip to the beginning of the images gallery

基本信息

产品名称	Quetmolimab (anti-CX3CL1), Fractalkine 抑制剂
别名	喹莫单抗(抗 CX3CL1)
英文别名	CX3C membrane-anchored chemokine \| C-X3-C motif chemokine 1 \| Neurotactin \| Small-inducible cytokine D1
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	CX3CL1
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	Fractalkine 抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG2
轻链亚型	kappa
SDS-PAGE	26.2 kDa (Light Chain) & 50.8 kDa (Heavy Chain), under reducing conditions; 201.9 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	2084037-83-0
分子类型	抗体

关联靶点（人）

CX3CL1 Tbio 分形运动(Fractalkine) (0 活性数据)

点击查看靶蛋白信息： CX3CL1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

ELISA: Quetmolimab (anti-CX3CL1) (Ab177929)

Quetmolimab (anti-CX3CL1) (Ab177929) - ELISA
Immobilized Recombinant Human CX3CL1 Protein (rp144831) at 1.0 μg/mL can bind Quetmolimab (anti-CX3CL1) (Ab177929) with the EC₅₀ of 41.08 ng/mL.

SEC: Quetmolimab (anti-CX3CL1) (Ab177929)

Quetmolimab (anti-CX3CL1) (Ab177929) - SEC
The purity of Quetmolimab (anti-CX3CL1) (Ab177929) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1202229	分析证书	Ab177929
ZJ23F1202230	分析证书	Ab177929
ZJ24F1214921	分析证书	Ab177929
ZJ24F1214920	分析证书	Ab177929
ZJ24F1214919	分析证书	Ab177929

引用文献

1. Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ. (1997) A new class of membrane-bound chemokine with a CX3C motif.. Nature, 385 (6617): (640-4). [PMID:9024663]
2. Timothy F Miles,Katja Spiess,Kevin M Jude,Naotaka Tsutsumi,John S Burg,Jessica R Ingram,Deepa Waghray,Gertrud M Hjorto,Olav Larsen,Hidde L Ploegh,Mette M Rosenkilde,K Christopher Garcia. (2018-06-09) Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.. eLife, 7 [PMID:29882741]
3. Pan, Y Y and 14 more authors.. (1997) Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation.. Nature, (5): [PMID:9177350]
4. Mizoue, L S LS, Bazan, J F JF, Johnson, E C EC and Handel, T M TM.. (1999) Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1.. Biochemistry, (2): [PMID:9931005]
5. Loftus, B J BJ and 18 more authors.. (1999) Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.. Genomics, (15): [PMID:10493829]
6. Hoover, D M DM, Mizoue, L S LS, Handel, T M TM and Lubkowski, J J.. (2000) The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement.. The Journal of biological chemistry, (28): [PMID:10770945]
7. Nishimura, Miyuki M and 8 more authors.. (2002) Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:12055230]
8. Xue, Xiaoguang X and 8 more authors.. (2011) Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor.. PLoS pathogens, [PMID:21829356]
9. Fujita, Masaaki M, Takada, Yoko K YK and Takada, Yoshikazu Y.. (2012) Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:23125415]
10. Caballero-Campo, Pedro P and 5 more authors.. (2014) A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.. Journal of cellular physiology, [PMID:23765988]
11. Fujita, Masaaki M, Takada, Yoko K YK and Takada, Yoshikazu Y.. (2014) The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.. PloS one, [PMID:24789099]
12. Burg, John S JS and 10 more authors.. (2015) Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.. Science (New York, N.Y.), (6): [PMID:25745166]
13. Hermand, Patricia P and 5 more authors.. (2016) Plasmodium falciparum proteins involved in cytoadherence of infected erythrocytes to chemokine CX3CL1.. Scientific reports, (22): [PMID:27653778]
14. Fong, A M and 6 more authors.. (1998) Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.. The Journal of experimental medicine, (19): [PMID:9782118]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Quetmolimab (anti-CX3CL1), Fractalkine 抑制剂

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

作用机制

图片

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器